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Fungal infections of the skin are really problems that affect the skin all over the world. These infections are often caused by fungi like Candida albicans, Trichophyton rubrum and Aspergillus Niger. Even though we have antifungal medicines that are used a lot using them for a long time can have bad effects make the fungi resistant and be very expensive.Because of this people are getting more interested in using plants to make medicines. This has led to the creation of cheaper herbal treatments. The goal of this study was to make and test a herbal cream using extracts from plants that are known to fight fungi.We got the extracts by using the right methods to extract them from the plants. Then we did some tests to see what was in them, like flavonoids, tannins, alkaloids and phenolic compounds. We made the cream by using the ingredients, including things that help mix everything together stabilize the cream preserve it and keep it moist. This was done to make sure the fungal infections of the skin cream was good and worked well...
Keywords
Antifungal herbal cream, Herbal formulation,Topical drug delivery,Polyherbal cream,Medicinal plant extracts
Introduction
Fungal infections of the skin are a problem all over the world. They are often caused by fungi like Candida albicans, Trichophyton rubrum and Aspergillus niger. These fungal infections can be treated with medicine. Using this medicine for a long time can have bad effects. It can also make the fungi resistant to the medicine. Cost a lot of money
Fungal infections of the skin are a deal and affect a lot of people every year. They usually happen on the skin, hair and nails. Fungi like Candida albicans, Trichophyton rubrum and Aspergillus Niger cause these infections. They cause problems like athlete’s foot and ringworm. These infections happen a lot, in humid places where people do not keep themselves clean and their bodies cannot fight off the infections.1 fungal infections of the skin are common worldwide. They are often caused by fungi like *Candida albicans* *Trichophyton rubrum* and *Aspergillus Niger*.
2. TYPES OF ANTI FUNGAL
2.1 Athlete’s Foot
Athlete’s foot is a fungal infection that affects the foot. It is often linked to sports. Anyone can get it. The fungus grows well in moist places like socks, shoes and locker rooms.
Symptoms of athlete’s foot can vary from person to person. It can look red on skin and dark brown on dark skin.
Common symptoms include:
discoloration and blisters on the foot
breaking skin
peeling or cracking skin
scaling and peeling skin
itching, stinging or burning sensations, on the foot
2.2 Ringworm
Ringworm is a skin infection caused by a fungus that lives on tissues like skin, hair and nails. It causes jock itch and athlete’s foot. When it appears elsewhere on the body it’s called ringworm.
Symptoms of ringworm:
A scaly ring-shaped area on the body
Itchiness
A clear or scaly area inside the ring, with bumps
Raised, expanding rings
2.3 Jock Itch
Jock itch is a fungal skin infection. Fungi love warm and damp environments and thrive in areas like the groin, buttocks and inner thighs.
Symptoms
Redness
Itching
Burning sensation
Flaking, peeling or cracking skin
2.4 Yeast infection
Vaginal yeast infections are common in women usually caused by Candida albicans.When Candida grows much, it disrupts the balance of bacteria and yeast in the vagina. This can happen because of antibiotics, stress, hormone imbalances or poor eating habits.
Symptoms of yeast infections are:
itching and swelling around the
burning sensations or pain during urination or intercourse
redness and soreness on and around the vagina
unusual vaginal discharge like gray clumps or a watery discharge
2.5 Nail Fungus
Nail fungus, also known as onychomycosis is a condition that affects the nails on hands or feet. It occurs when fungi invade the nail bed or nail plate.
Symptoms:
Discoloration of the nail
Thickening of the nail
Brittleness of the nail
Separation of the nail, from the nail bed
Pain or discomfort
Smell
DIFFERENT TYPES OF FUNGAL INFECTION
3. Causes of Fungal
Fungal infections are caused by the overgrowth of fungi on skin, nails, hair or inside the body. Main causes include:
Infection by fungi like Candida or Trichophyton
Poor personal hygiene
sweating
Weak immune system
Prolonged use of antibiotics or steroids
Direct contact, with persons or contaminated surfaces
4. Ingredients used in anti-fungal herbal cream:
4.1 NEEM
Biological name – Azadirachta indica
Common name – Neem, Nimba, margosa tree
Synonyms – Malia azadirachta
Kingdom – Plantae
Family – Meliaceae
Genus – Azadirachta
Species – Azadirachta indica
Neem is a very important plant used in herbal skin care. It has been used for a time to treat various skin problems because of its strong antibacterial, antifungal, anti-inflammatory and purifying properties. Neem plays a role in controlling acne by targeting its root causes, such as bacterial growth, excess oil production and skin inflammation
Aloe vera is really good for skin for people with acne. It helps calm. Heal the skin.
It's rich in stuff like vitamins, minerals and enzymes that keep skin healthy.
In creams that help with acne aloe vera gel is used as a base because it keeps skin hydrated without making it greasy.
4.3 TURMERIC
Biological name – Curcuma longa
Common name – Turmeric
Synonyms – Curcuma domestica, Haldi, Indian saffron
Kingdom – Plantae
Family – Zingiberaceae
Genus – Curcuma
Species – Curcuma longa
Turmeric is a herb that people have used for a time to help with health problems, including acne. It has strong antiinflammatory and antibacterial properties that help reduce acne. The main thing in turmeric that helps with this is curcumin. It plays a role in reducing skin inflammation and stopping acne.
When we use turmeric in creams it helps reduce redness and swelling that comes with pimples. Turmeric also stops bacteria from growing which is one of the causes of acne. It calms down skin and stops breakouts from getting worse.
4.4 Tulsi
Biological name – Ocimum tenuiflorum (Ocimum sanctum)
Common name – Tulsi, Holy Basil
Synonyms – Tulasi, sacred basil
Kingdom – Plantae
Family – Lamiaceae
Genus – Ocimum
Species – Ocimum tenuiflorum
Tulsi is one of the most important herbs in traditional Indian medicine, especially Ayurveda. It is widely grown in subtropical regions. In India Tulsi is considered sacred. Is often grown in household gardens.
Tulsi has a lot of compounds like eugenol and ursolic acid that give it its properties. For centuries Tulsi has been used to promote health and prevent diseases. It is commonly consumed as leaves, dried powder, herbal tea or extracts.
4.5 CLOVE
Biological name – Syzygium aromaticum
Common name – Clove
Synonyms – Eugeniacaryophyllata
Kingdom– Plantae
Family – Myrtaceae
Genus – Syzygium
Species– Aromaticum
Clove is a spice that comes from a tree. It has a smell and taste. Clove has been used for a time as a medicine and as a spice in food.
Clove is very good at fighting off bacteria and viruses. It also helps to reduce inflammation and pain.. Because it has antioxidant properties it helps to keep the body safe from damage.
4.6 BANANA PEEL
Biological name– Musa paradisiaca
Common name – Banana
Synonyms – Musa sapientum
Kingdom – Plantae
Family– Musaceae
Genus – Musa
Species– Paradisiaca
Banana peel is the protective covering of the banana fruit. It is generally considered a by-product or waste material. However recent research has shown that Banana peel has nutritional and medicinal value.
It contains bioactive compounds such as phenolics, flavonoids, carotenoids and antioxidants along with essential nutrients like potassium, magnesium, fiber and small amounts of protein.
Traditionally Banana peel has been used in folk remedies for skin care and wound healing. In years scientific studies have explored its potential applications in agriculture, environmental management and the pharmaceutical and cosmetic industries.
s.no
Ingredient
Quantity
properties
01
Neem
20ml
Antimicrobial, Anti-inflammatory
02
Turmeric
20ml
Antimicrobial , Antioxidant
03
Aloe vera
10ml
Antiseptic, carminative
04
Tulsi
5ml
Antioxidant, nutrient source, wound healing
05
Clove
5ml
Antioxidant , anti-inflammatory, antibacterial
06
Banana peel
5gm
Antimicrobial, anti-inflammatory
07
Beewax
1.5gm
Emollient
08
Borax
0.2gm
buffer
09
Silica gel
0.1gm
Adsorbent
10
Bentonite
4gm
Thickening agent
11
Methylparaben
0.2gm
preservative
12
Rose oil
q.s
fragrance
MATERIAL AND METHOD
5. Application for anti-fungal herbal cream
Treatment of superficial fungal infection .
Management of skin irritation and itching
Prevention of recurrence
Wound protection
Safe for long term use
Cosmetic and demagogical use
6. Precautions
Patch Test Before Use
You should do a patch test before using cream to make sure you are not allergic to it.
For External Use
Antifungal cream should only be used on the skin and not ingested.
Avoid Contact with Eyes and Mucous Membranes
CONCLUSION
Antifungal herbal cream is an natural way to fight fungal infections. It is made from plant extracts like Tulsi and Clove. This cream has antifungal, antimicrobial, antiinflammatory and antioxidant properties.
* It helps treat fungal infections.
* It gives relief from itching.
* It prevents infections.
* It keeps skin healthy.
Herbal creams like this one have side effects. They are good for the skin and the environment. This makes them suitable for long-term use.
Antifungal herbal cream can be very useful in skin care and cosmetics. More studies can help make it even better. We can try combining it with natural ingredients. This can help prove that it is an alternative, to regular antifungal treatments.
With care and use antifungal herbal cream can be very effective. It has a lot of potential in helping people with skin issues.
REFERENCES
Amanlou, Massoud, et al. "Miconazole gel compared with Zataria multiflora Boiss. gel in the treatment of denture stomatitis." Phytotherapy Research: An International JournalDevoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives 20.11 (2006): 966-969.
Loreto, Erico S., and Juliana SM Tondolo. "Introductory Chapter: Epidemiology of Invasive Fungal Infection-An Overview." Fungal Infection (2019).
Richardson, Malcolm D., and David W. Warnock. Fungal infection: diagnosis and management. John Wiley & Sons, 2012.
Sanguinetti, M., Posteraro, B., Beigel man-Aubry, C., Lamoth, F., Dunet, V., Slavin, M., & Richardson, M. D. (2019). Diagnosis and treatment of invasive fungal infections: looking ahead. Journal of Antimicrobial Chemotherapy, 74(Supplement_2), ii27-ii37.
Fothergill, A. W. (2006). Miconazole: a historical perspective. Expert Review of Anti infective Therapy, 4(2), 171-175.
Alka R. Bhure1, Saurabh J. Patil2Formulation and Evaluation of Polyherbal Antifungal Cream Research Journal of Pharmacognosy and Phytochemistry 17 (4), 253-257, 2025
Arati D. Powar* and Dr. Sachin A. Nitave World Journal of Pharmaceutical Research World Journal Of Pharmaceutical Research, 906-911, 2022
and Aravinda Siriwardhene Evaluation of Antifungal Activity of Languas galangal Rhizome and Development of a Topical Antifungal Cream Medicines
(6), 34, 2023 10. 4. Deepa V 1, Gururaj S Kulkarni 1, * and Padma M Paarakh Formulation and evaluation of topical anti-microbial herbal cream World J. Biol. Pharma. Hlth Sci 12 (2), 156-167, 2022
KUSUM KAUSHIK*, SHWETA AGARWALROLE OF HERBAL ANTIFUNGAL AGENTS FOR THE MANAGEMENT OF FUNGAL DISEASES
SYSTEMATIC REVIEWAsian J Pharm Clin Res 12 (7), 34-40, 2019
Kamilia F Taha, Seham S El-hawary, Hala M El-hefnawy, Mona I Mabrouk, Rania A Sanad, Marwa Y El HarriryFormulation and assessment of a herbal hair cream against certain dermatophytes International Journal of Pharmacy and Pharmaceutical Sciences, 167-173, 2016
Mr. Anuch Ninad Bhavsar1, Mr. Pranay Sanjay Bafna2, Dr. Javesh K. Patil3Herbal Anti fungal Cream: A Natural Approach to
OKAFO SE1*, ANIE CO2, OMOH JO1EVALUATION OF HERBAL CREAMS FORMULATEDUSING CHAPTER REFERENCES Rungta Institute of Pharmaceutical Sciences, Bhilai CG Page 41Biology, Pharmacy and Allied Sciences 11 (5), 2179-2190, 2022
Sujata P. Choudhari, Rahul M. Dhawale, Vikrant V. Wadkar, Arun A. Pawar Formulation and Evaluation of Herbal Antifungal Cream of Zingiber officinale Research Journal of Science and Technology 15 (3), 129-134, 2023
Anuraag Rai, Bhavik Chauhan, Devshree N Parmar Testing of Antifungal Activity of Herbal Cream Made with Natural Herbal Oils (Origanum vulgare,
Melaleuca alternifolia, Anethum graveolans)Research Journal of Pharmacognosy and Phytochemistry 14 (3), 185-191, 2022
17
. ETHANOLIC EXTRACT OF CARICA PAPAYA LEAVE International Journal of
Esther Offiong Asuquo, Endurance Egwu Ukam, Emmanuel Emmanuel Edet, Victoria Onem Ufala Formulation and evaluation of banana peel-based herbal cream for antibacterial and antifungal applications in cosmetic products Journal of Dermatologic Science and Cosmetic Technology, 100106, 2025
Shashikant D Barhate Formulation Development and Evaluation of Antifungal Topical Cream of Itraconazole Research Journal of Topical and Cosmetic Sciences 16 (1), 21-26, 2025
Miriam GU Nwaneri, Ugochukwu M Okezie, Uchenna C Ogwaluonye, Ijeoma N Ebenebe, SO Esimone Topical antifungal herbal formulations with broad spectrum activity International Journal of Innovative and Advanced Studies 10 (7), 49-54, 2023
Amanlou, Massoud, et al. "Miconazole gel compared with Zataria multiflora Boiss. gel in the treatment of denture stomatitis." Phytotherapy Research: An International JournalDevoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives 20.11 (2006): 966-969.
Loreto, Erico S., and Juliana SM Tondolo. "Introductory Chapter: Epidemiology of Invasive Fungal Infection-An Overview." Fungal Infection (2019).
Richardson, Malcolm D., and David W. Warnock. Fungal infection: diagnosis and management. John Wiley & Sons, 2012.
Sanguinetti, M., Posteraro, B., Beigel man-Aubry, C., Lamoth, F., Dunet, V., Slavin, M., & Richardson, M. D. (2019). Diagnosis and treatment of invasive fungal infections: looking ahead. Journal of Antimicrobial Chemotherapy, 74(Supplement_2), ii27-ii37.
Fothergill, A. W. (2006). Miconazole: a historical perspective. Expert Review of Anti infective Therapy, 4(2), 171-175.
Alka R. Bhure1, Saurabh J. Patil2Formulation and Evaluation of Polyherbal Antifungal Cream Research Journal of Pharmacognosy and Phytochemistry 17 (4), 253-257, 2025
Arati D. Powar* and Dr. Sachin A. Nitave World Journal of Pharmaceutical Research World Journal Of Pharmaceutical Research, 906-911, 2022
and Aravinda Siriwardhene Evaluation of Antifungal Activity of Languas galangal Rhizome and Development of a Topical Antifungal Cream Medicines
(6), 34, 2023 10. 4. Deepa V 1, Gururaj S Kulkarni 1, * and Padma M Paarakh Formulation and evaluation of topical anti-microbial herbal cream World J. Biol. Pharma. Hlth Sci 12 (2), 156-167, 2022
KUSUM KAUSHIK*, SHWETA AGARWALROLE OF HERBAL ANTIFUNGAL AGENTS FOR THE MANAGEMENT OF FUNGAL DISEASES
SYSTEMATIC REVIEWAsian J Pharm Clin Res 12 (7), 34-40, 2019
Kamilia F Taha, Seham S El-hawary, Hala M El-hefnawy, Mona I Mabrouk, Rania A Sanad, Marwa Y El HarriryFormulation and assessment of a herbal hair cream against certain dermatophytes International Journal of Pharmacy and Pharmaceutical Sciences, 167-173, 2016
Mr. Anuch Ninad Bhavsar1, Mr. Pranay Sanjay Bafna2, Dr. Javesh K. Patil3Herbal Anti fungal Cream: A Natural Approach to
OKAFO SE1*, ANIE CO2, OMOH JO1EVALUATION OF HERBAL CREAMS FORMULATEDUSING CHAPTER REFERENCES Rungta Institute of Pharmaceutical Sciences, Bhilai CG Page 41Biology, Pharmacy and Allied Sciences 11 (5), 2179-2190, 2022
Sujata P. Choudhari, Rahul M. Dhawale, Vikrant V. Wadkar, Arun A. Pawar Formulation and Evaluation of Herbal Antifungal Cream of Zingiber officinale Research Journal of Science and Technology 15 (3), 129-134, 2023
Anuraag Rai, Bhavik Chauhan, Devshree N Parmar Testing of Antifungal Activity of Herbal Cream Made with Natural Herbal Oils (Origanum vulgare,
Melaleuca alternifolia, Anethum graveolans)Research Journal of Pharmacognosy and Phytochemistry 14 (3), 185-191, 2022
17
. ETHANOLIC EXTRACT OF CARICA PAPAYA LEAVE International Journal of
Esther Offiong Asuquo, Endurance Egwu Ukam, Emmanuel Emmanuel Edet, Victoria Onem Ufala Formulation and evaluation of banana peel-based herbal cream for antibacterial and antifungal applications in cosmetic products Journal of Dermatologic Science and Cosmetic Technology, 100106, 2025
Shashikant D Barhate Formulation Development and Evaluation of Antifungal Topical Cream of Itraconazole Research Journal of Topical and Cosmetic Sciences 16 (1), 21-26, 2025
Miriam GU Nwaneri, Ugochukwu M Okezie, Uchenna C Ogwaluonye, Ijeoma N Ebenebe, SO Esimone Topical antifungal herbal formulations with broad spectrum activity International Journal of Innovative and Advanced Studies 10 (7), 49-54, 2023
Rungta Institute of Pharmaceutical Science & Research
Dr. Gyanesh Sahu
Co-author
Rungta Institute of Pharmaceutical Science & Research
Suchita Wamankar
Co-author
Rungta Institute of Pharmaceutical Science & Research
Rupesh Kumar, Akanksha sahu, Dr. Chanchal Deep kaur ,Dr.Gyanesh Sahu, Suchita Wamankar, Review On Formulation And Evaluation Anti Acne Herbal Cream, Int. J. of Pharm. Sci., 2026, Vol 4, Issue 5, 878-885, https://doi.org/10.5281/zenodo.20034977