Archive

Abstract

The current article is focused on ideal characteristics, patented technologies, significant features and formulating methods including the use of superdisintegrants, which achieve rapid onset of action, better patient compliance and increased bioavailability. Sublingual tablets dissolve instantaneously, releasing the drug, within a few seconds without the need of water and chewing. The objective behind this review was to summaries the benefits of sublingual formulation, mechanism of action, advantages of route of administration, factors affecting permeability of drug, various in vitro evaluation parameters and commercially available sublingual dosage forms. Different sublingual technologies address pharmaceutical industries and patient needs to enhanced lifecycle and appropriate dosing for pediatric, geriatric, psychiatric patients also patients with dysphagia. Consequently, many scientific techniques including freeze drying, molding, spray drying, sublimation, direct compression, mass extrusion, melt granulation method etc. have been employed for development of sublingual tablets. Due to its better stability and bioavailability, the sublingual route could be considered as a promising alternative to oral and parenteral routes.

Keywords

Sublingual tablets, patient compliance, sublingual formulation, scientific techniques, parenteral routes

Reference

  1. Thulluru A., Mahammed N., C. Madhavi, K. Nandini, S. Sirisha, D. Spandana (2019)Sublingual Tablets - An Updated Review. Asian Journal of Pharmaceutical Research 9(2): 97-103. 
  2. Sarkhejiya NA, Patel VP and Pandya DJ. (2013) Sublingual delivery: A promising approach to improve bioavailability. Pharmaceutical Science Monitor; 4(2): 3870-89.
  3. Hooda R, Tripathi M and Kapoor K. (2012) A review on oral mucosal drug delivery system. Pharma Innovation; 1(1):13-19.
  4. Jaiswani R., Prakash A., Mishra D. K., D. K. J. (2014) Sublingual Tablets: An Overview. Journal of Drug Delivery Research; 3(4): 10-21.
  5. P. Prathusha and Kamarapu P. (2017) A Review on Sublingual Tablets. Journal of Formulation Science & Bioavailability; 1(1): 1-2.
  6. K. P. Nibha, Pancholi S. S. (2012) An overview on: Sublingual route for systemic drug delivery. Advance Drug Delivery Reviews; 2: 913-23.
  7. N. Narang, Sharma J. (2011) Sublingual mucosa as a route for systemic drug delivery. International Journal of Pharmacy and Pharmaceutical Sciences; 3(2): 18-22.
  8. Khan A. B., Kingsley K., Caroline P. (2017) Sublingual Tablets and the Benefits of the Sublingual Route of Administration. Journal of Pharmaceutical Research; 16(3): 257-67.
  9. Sah S., Badola A., Kothiyal P. (2016) Sublingual Tablets: An Overview. Indian Journal of Pharmaceutical and Biological Research; 4(2): 20-26.
  10. N. Narang, Sharma J. (2011) Sublingual mucosa as a route for systemic drug delivery. International Journal of Pharmacy and Pharmaceutical Sciences; 3:18–22.
  11. Vats K. A., H.G.Shivakumar, Chaudhari C.A. (2016) Sublingual Drug Delivery:An Extensive Review, International Journal for Pharmaceutical Research Scholars; 5(1): 9-19.
  12. Makwana Saroj and Kharadi R. (2018) A Review on Sublingual Formulation, World Journal of Pharmacy and Pharmaceutical Sciences; 7(9): 1300-1306.
  13. Saroha K. (2014) A Review on Sublingual tablets. Asian Journal of Pharmaceutical Research; 8(1): 98–111.
  14. Singh Manisha, Chitranshi N., Pal S. A., Arora V., Siddiqi W. A. (2012) An Overview on fast Disintegrating Sublingual Tablets, International Journal of Drug Delivery; 4(4): 407-417.
  15. Bind A. K., Gnanarajan G. and Kothiyal P. (2013) A Review: Sublingual Route for Systemic Drug Delivery, International Journal of Drug Research and Technology; 3(2): 31-36.
  16. Labhade S., Malode C., Rawal V., Rupvate S. (2019) A Review on Sublingual Drug Delivery System, Journal of Drug Delivery and Therapeutics; 9(3):684-688.

image
Ashish Gupta
Corresponding author

Acropolis Institute of Pharmaceutical Education and Research, Indore, Madhya Pradesh, India – 453771

image
T. S. Kanade
Co-author

Acropolis Institute of Pharmaceutical Education and Research, Indore, Madhya Pradesh, India – 453771

image
S. Mahajan
Co-author

Acropolis Institute of Pharmaceutical Education and Research, Indore, Madhya Pradesh, India – 453771

image
G. N. Darwhekar
Co-author

Acropolis Institute of Pharmaceutical Education and Research, Indore, Madhya Pradesh, India – 453771

T. S. Kanade, A. Gupta*, S. Mahajan, G. N. Darwhekar, Review on Sublingual Tablets – A Promising Formulation for Instant Action, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 7, 250-260. https://doi.org/10.5281/zenodo.8156354

More related articles
Sublingual Dosage Form...
Namrata S. Revar, Samruddhi B. Sawant, Sanjeevani D. Rupwate, ...
An Overview of Lungs Cancer...
Aditya Chaudhary, Nitin Kumar, ...
Beyond Scrubs: Azelaic Acid’s Chemical Exfoliati...
Gowtham Sundarrajan, Ariharasivakumar G., Abarnadevika A., Priyan...
The Haemostatic Effect of Jati Patra Swaras In Sravi Arsha...
Mangesh Udmale, Shirke J.M, Prakash Mane, Sanjay Babar, Sachin Rohani, Vinayak Joshi, ...
A Review on Therapeutic Aspects of Artesunate in The Treatment of Various Diseas...
Shital B.Bharambe, Shailesh Jawarkar, Madhuri Game, V. M Whagulkar, Monika Jadhav, ...
Related Articles
Male And Female Infertility Which Cause Child Birth Problem...
Koshish Gabhane, Aman S. Maharaj, Ankita S. Kadu, Siya V. Chawan, Suyog R. Ambadkar, ...
Formulation Development and Evaluation of Herbal Candy Containing Lantana Camara...
Khandagale. S. S, Salve Dvitiya S, Dabhade Sakhi K., Madane Samnath J. , Mahalkar Ram B. , Patil Omk...
Anti Cancer Activity Of Balenites Aegyptiaca ...
Pragati Padse, Jyoti Dhakne, Rushikesh Nikam, Pratiksha Padol, Pooja Aher, Rahul Polke, ...
A Review on: Pharmacogenomics with AI (Clinical Sematic Network )...
Amol V. Supekar, Tagare Chetan B., Girhe Akshay R., Tanpure Siddharth S., Zirpe Pandhori , ...
Sublingual Dosage Form...
Namrata S. Revar, Samruddhi B. Sawant, Sanjeevani D. Rupwate, ...
More related articles
Sublingual Dosage Form...
Namrata S. Revar, Samruddhi B. Sawant, Sanjeevani D. Rupwate, ...
An Overview of Lungs Cancer...
Aditya Chaudhary, Nitin Kumar, ...
Beyond Scrubs: Azelaic Acid’s Chemical Exfoliation Journey In Cosmetic Dermato...
Gowtham Sundarrajan, Ariharasivakumar G., Abarnadevika A., Priyanka S., ...
Sublingual Dosage Form...
Namrata S. Revar, Samruddhi B. Sawant, Sanjeevani D. Rupwate, ...
An Overview of Lungs Cancer...
Aditya Chaudhary, Nitin Kumar, ...
Beyond Scrubs: Azelaic Acid’s Chemical Exfoliation Journey In Cosmetic Dermato...
Gowtham Sundarrajan, Ariharasivakumar G., Abarnadevika A., Priyanka S., ...