Acropolis Institute of Pharmaceutical Education and Research, Indore, Madhya Pradesh, India – 453771
The current article is focused on ideal characteristics, patented technologies, significant features and formulating methods including the use of superdisintegrants, which achieve rapid onset of action, better patient compliance and increased bioavailability. Sublingual tablets dissolve instantaneously, releasing the drug, within a few seconds without the need of water and chewing. The objective behind this review was to summaries the benefits of sublingual formulation, mechanism of action, advantages of route of administration, factors affecting permeability of drug, various in vitro evaluation parameters and commercially available sublingual dosage forms. Different sublingual technologies address pharmaceutical industries and patient needs to enhanced lifecycle and appropriate dosing for pediatric, geriatric, psychiatric patients also patients with dysphagia. Consequently, many scientific techniques including freeze drying, molding, spray drying, sublimation, direct compression, mass extrusion, melt granulation method etc. have been employed for development of sublingual tablets. Due to its better stability and bioavailability, the sublingual route could be considered as a promising alternative to oral and parenteral routes.
T. S. Kanade, A. Gupta*, S. Mahajan, G. N. Darwhekar, Review on Sublingual Tablets – A Promising Formulation for Instant Action, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 7, 250-260. https://doi.org/10.5281/zenodo.8156354