Archive

Abstract

The present research work is based on the formulation of herbal granules by incorporating the aqueous extract of onion peels, garlic peels, potato peels, and chilli pedicles. The aqueous extract of the plant was extracted and then subjected to phytochemical tests, fluorescence tests, antioxidant activity, and anticancer activity. Then it was formulated into granules and evaluated for various parameters like angle of repose, bulk density, and tapped density. The preliminary chemical studies showed that the extract contains flavonoids, alkaloids, glycosides, carbohydrates, vitamins, and tannins. The formulated granules exhibited good flow properties, which showed good angle of repose, bulk density, and tapped density. The antioxidant and anticancer activity showed the herbal granules to be more potent. An herbal granule was prepared, as this particular formulation can be used for plant growth hormone. The IC50 value of aqueous extract shows 166.486 ?g/ml for antioxidant activity (shown in Table no 3.) and IC50 value of Standard Ascorbic acid shows 23.7148 ?g/ml antioxidant activity. (Shown in Table no. 3). The LC50 value of aqueous extract shows 212.97 ?g/ml for anticancer activity (shown in Table no.4) & The LC50 value of standard extract shows 0.00 ?g/ml for anticancer activity. (Shown in Table no.4).

Keywords

Antioxidant, Anticancer, brine shrimp, Soxhlet apparatus, LC50 Value, IC50 Value

Reference

  1. I.G.O. Crnivec, ? M. Skrt, D. Seremet, ? M. Sterni?sa, D. Far?cnik, E. Strumbelj, ? A. Poljan?sek, N. Cebin, L. Poga?cnik, S.S. Mo?zina, M. Humar, D. Komes, N.P. Ulrih, Waste streams in onion production: bioactive compounds, quercetin and use of antimicrobial and antioxidative properties, Waste Manag. 126 (2021) 476–486, https://doi.org/10.1016/j.wasman.2021.03.033
  2. E.-Y. Choi, H. Lee, J.S. Woo, H.H. Jang, S.J. Hwang, H.S. Kim, W.S. Kim, Y.S. Kim, R. Choue, Y.J. Cha, J.E. Yim, W. Kim, Effect of onion peel extract on endothelial function and endothelial progenitor cells in overweight and obese individuals, Nutrition 31 (9) (2015) 1131–1135, https://doi.org/10.1016/j.nut.2015.04.020.
  3. Maheshwari, S. Singh, S. Dhumal, Radha, M. Thakur, S. Punia, V. Satankar, R. Amarowicz, M. Mekhemar, Custard apple (Annona squamosa L.) leaves: nutritional composition Tomar, U. Prajapati, V. Saurabh, M. Hasan, M. Sasi, C. M, phytochemical profile, and health-promoting biological activities, Biomolecules 11 (5) (2021) 614, https://doi.org/10.3390/ biom11050614.
  4. FAO (2013, 2016) Food Agriculture Organization of the United Nations Statistics Division. 
  5. Chiellini E, Cinelli P, Chiellini F, et al. (2004) Environmentally degradable bio?based polymeric blends and composites. Macromol Biosci 4: 218–231
  6. Maldonado AFS, Mudge E, Gänzle MG, et al. (2014) Extraction and fractionation of phenolic acids and glycoalkaloids from potato peels using acidified water/ethanol-based solvents. Food Res Int 65: 27–34.
  7. S. Ejaz, I. Chekarova, J. W. Cho, S. Y. Lee, S. Ashraf, and C. W. Lim, "Effect of aged garlic extract on wound healing: A new frontier in wound management," Drug and Chemical Toxicology, vol. 32, pp. 191-203, 2009.Available at: https://doi.org/10.1080/01480540902862236.
  8. B. O. T. Ifesan, E. A. Fadipe, and B. T. Ifesan, "Investigation of antioxidant and antimicrobial properties of garlic peel extract (Allium sativum) and its use as natural food additive in cooked beef," International Journal of Scientific Reports, vol. 3, pp. 711–721, 2014.
  9. Capsaicinoids What Makes Chillies Hot. Available from: http://www. chm.bris.ac.uk/motm/chilli/capsaicin.htm.
  10. Available from: http://www.sciencealert.com/the-compound-thatmakes-chillies-spicy-could-help-kill-cancer-cells.
  11. Phillips KM, Ruggio DM, Ashraf-Khorassani M, Haytowitz DB. Difference in folate content of green and red sweet peppers (Capsicum annuum) determined by liquid chromatography-mass spectrometry. J Agric Food Chem 2006;54(26):9998-10002.
  12. Saili. P. Rajput, Sneha P. Khandale, Dr. Ganesh G. Tapadiya, Sadhana P. Rajput. An Effect of Onion Peel Water on Various Plant Disease and Plant Growth. January 2022 IJSDR | Volume 7 Issue 1. IJSDR2201052 International Journal of Scientific Development and Research (IJSDR) www.ijsdr.org page no.333.
  13. Khandelwal K. R. 1995. Practical Pharmacognosy, Techniques and Experiments Nirali Prakashan. First edition. 149-159.
  14. Harborne, J.B., “Phytochemical methods- A Guide to Modern Techniques of plant analysis”, 2nd Edition, chapman and hall, London.1984, 4-120.
  15. Alam N. Brishti N J. Rafiquzzaman (2013) Review on in vivo and in vitro methods caluation of antioxidant activity. Saudi Pharmaceutical Journal 21 143-152.
  16. Md. Asaduzzaman, Dr. Md. Sohel Rana, S.M. Raqibul Hasan, Md. Monir Hossain, Nityananda Das, Cytotoxic (Brine Shrimp Lethality Bioassay) And Antioxidant Investigation Of Barringtonia Acutangula (L.) Md. Asaduzzaman Et Al. / International Journal of Pharma Sciences and Research (IJPSR), ISSN: 0975-9492 Vol. 6 No.8 Aug 2015 1179-1183.
  17. Pharmaceutical practical manual by Dr. P. Muthu Prasanna & Dr. k. Prabha 2nd edition 2010 Birla publication page no. 38.

image
Sushant Mane
Corresponding author

Sahyadri College of Pharmacy Methwade, Sangola-413307.

image
Sangram Falake
Co-author

Sahyadri College of Pharmacy Methwade, Sangola-413307.

image
Somnath Mali
Co-author

Sahyadri College of Pharmacy Methwade, Sangola-413307.

image
Dr. Ashpak Tamboli
Co-author

Sahyadri College of Pharmacy Methwade, Sangola-413307.

Sushant Mane*, Sangram Falake, Somnath Mali, Dr. Ashpak Tamboli, To Study Antioxidant & Anticancer activity of aqueous extract of Onion peels, Potato peels, Garlic peels and Chilli pedicle, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 7, 155-161. https://doi.org/10.5281/zenodo.8113840

More related articles
Understanding Leprosy : A Comprehensive Review ...
Pathan Farhat Al., Khan Nida S., Khan Laiba Noor W., Shaikh Arshi...
Liquid Liquid Separation And Determination Of Beta...
Edebi N. Vaikosen, Ruth C. Worlu, Samuel J. Bunu, Ebiere Dode, Ma...
Understanding Leprosy : A Comprehensive Review ...
Pathan Farhat Al., Khan Nida S., Khan Laiba Noor W., Shaikh Arshi...
Design Development And Evaluation Of Floating Drug Delivery System For Lornoxica...
Shiv Sagar Mahapatra, Akanksha Patel, Manmath Purohit, ...
A Literature Review On Silk Maize Health Benefits And It’s Pharmacological Eff...
Patel umangkumar Rajeshbhai, Paswan Praveenkumar, Patel Priya , Patel Nidhi , Sinha Neeta, ...
Assessing Medication Appropriateness: A Prospective Observational Study At A Ter...
Chethan Prabhu, Krishnananda Kamath K, Ramakrishna Shabaraya, ...
Related Articles
A Comprehensive Overview Of HPLC Method Development And Validation...
Sayali V. Ganjiwale, A. P. Dewani, A. V. Chandewar, ...
Advances Of NSAIDS In Ankylosing Spondylitis...
R. Meghana, A. V. Kishore Babu, A. Srinivasa Rao, ...
Extraction, Phytochemical Investigation and Antimicrobial Activity of Hibiscus R...
Ganesh D. Barkade, Akshata B. Sinare, Mayur G. Tandale, Rutuja B. Sonawane, Rutuja R. Sumbe, ...
Understanding Leprosy : A Comprehensive Review ...
Pathan Farhat Al., Khan Nida S., Khan Laiba Noor W., Shaikh Arshin A., ...
More related articles
Understanding Leprosy : A Comprehensive Review ...
Pathan Farhat Al., Khan Nida S., Khan Laiba Noor W., Shaikh Arshin A., ...
Liquid Liquid Separation And Determination Of Betamethasone, Clotrimazole And Ne...
Edebi N. Vaikosen, Ruth C. Worlu, Samuel J. Bunu, Ebiere Dode, Mary Doctor, ...
Understanding Leprosy : A Comprehensive Review ...
Pathan Farhat Al., Khan Nida S., Khan Laiba Noor W., Shaikh Arshin A., ...
Understanding Leprosy : A Comprehensive Review ...
Pathan Farhat Al., Khan Nida S., Khan Laiba Noor W., Shaikh Arshin A., ...
Liquid Liquid Separation And Determination Of Betamethasone, Clotrimazole And Ne...
Edebi N. Vaikosen, Ruth C. Worlu, Samuel J. Bunu, Ebiere Dode, Mary Doctor, ...
Understanding Leprosy : A Comprehensive Review ...
Pathan Farhat Al., Khan Nida S., Khan Laiba Noor W., Shaikh Arshin A., ...