Government College of Pharmacy, Aurangabad, 431005
The mouth ulcers are round or oval sores which give rise to redness, pain and discomfort leading to alteration of person food choice while healing process. Aphthous stomatitis and Local trauma are the most common types of oral ulcers. The aim of present study was to formulate and evaluate herbal oral gel of Polyalthia longifolia leaves extract for treatment of mouth ulcer. Polyalthia longifolia leave has been usually used to govern diseases such as treat fever, gonorrhoea, uterus ailments, mouth ulcer, heart problems and it also possesses good antimicrobial, antifungal, antibacterial activity, and anticancer activity. Polyalthia longifolia comprises essential phytoconstituents such as terpenoid, alkaloid, gallic acid, flavonoid: rutin, clerodane diterpene: 16 (R and S)-hydroxy-cleroda-3,13(14)Z-dien-15,16-olide, kolavenic acid, Polylongine, and Longimide. The herbal oral gel formulation was prepared by using extract of Polyalthia longifolia leaves, gelling agent (Carbopol 934, hydroxypropyl methylcellulose, or sodium carboxy methylcellulose (SCMC)), propylene glycol, methyl paraben, propyl paraben, and distilled water. The pH (6.7-7.2) of oral mucosa was maintained by dropwise addition of triethanolamine. The physicochemical parameters of formulations such as pH, spreadability, viscosity, extrudability, gelling strength, drug content, antifungal study and in-vitro drug release study were studied.The formulated gel was transparent, homogeneous and pH ranges from 6.8 to 7.0. Formulation showed allowable rheological behaviour with appropriate spreadability and extrudability property. It showed acceptable mechanical characteristics and satisfactory % drug release. The gel was smooth without any interactions between drug and polymer. Anti-fungal study of formulation showed excellent efficacy against Candida albicans, Staphylococcus aureus, Pseudomonas aeruginosa. B2c formulation showed the prominent satisfactory results. From the experimental evidence of in-vitro study, it was observed that Polyalthia longifolia extract contained terpenoid, so it showed significant antiulcer effect. Developed herbal formulation was stable, effective and safe for the treatment of mouth ulcer.
S. S. Chavan, V. D. Thombare, B Shejul*, Development and Evaluation of Herbal Oral Gel Containing Extract of Polyalthia longifolia leaves for the Treatment of Mouth Ulcers, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 12, 389-403. https://doi.org/ 10.5281/zenodo.10389752
10.5281/zenodo.10389752
