Archive

Abstract

Numerous advantages of gels Delivery of hydrophobic medications is severely limited. In order to overcome this limitation and take advantage of the unique properties of gels, even a hydrophobic medicinal moiety is being treated with an emulsion-based approach. The dosage form produced by mixing gels and emulsions is called an emulgel. Dermatological pharmacology is unique in that it uses the skin as a target organ that is directly accessible for diagnosis and treatment. The interaction of hydrophilic cornified cells with hydrophobic intercellular material blocks both hydrophilic and hydrophobic molecules. Research has shown that the presence of a gelling component in the aqueous phase transforms a conventional emulsion into an emulgel. These emulgels are superior than both novel vesicular systems and traditional systems in a number of respects. Compared to current topical drug delivery technologies, emulgels are preferable because different permeability enhancers can increase the impact. Emulgels are a useful supplement to the methods currently utilized to apply topical medications.

Keywords

Emulgels, Novel Vesicular Systems, Traditional Systems

Reference

  1. KshirsagarNA.DrugDeliverySystems.Ind.J. Pharmacol.2000;32:S54-S61.
  2. Rashmi M. Topical gel: A review august vol.2008;availablefromhttp://www.pharmainfo.com.
  3. Sharma S. Topical preparations are used forthelocalizedeffectsatthesiteoftheirapplication by virtue of drug penetration intotheunderlyinglayersofskinormucousmembranes.Pharmaceuticalreviews2008;6:1.
  4. LaithyHM.andElshabouryKMF.ThedevelopmentofCutinaLipogelsandgelmicroemulsion for topical administration offluconazole. Ame Pharm Sci. PharmSciTech.2003;3:10 25.
  5. Kumar L, Verma R. In vitro evaluation of topicalgelpreparedusingnaturalpolymer. International Journal of Drug Delivery 2010;2:58-63.
  6. Gupta A, Mishra AK, Singh AK, Gupta V, Bansal P. Formulation and evaluation of topical gel of diclofenac sodium using different polymers. Drug Invention Today 2010; 2:250-253.
  7. AnselHC,AllenLVJr.,PopovichNG.PharmaceuticalDosageFormsandDrugDeliverySystems.NewYorkLippincottWilliamsandWilkins 7thed.; 1999.
  8. Jain A, Gautam SP, Gupta, Jain S, Development, and characterization of Ketoconazole emulgel for topical drug delivery. Der Pharmacia Sinica,1(3):221- 231, (2010).
  9. 3.StanosSP.TopicalAgentsfortheManagement of Musculoskeletal Pain. J PainSymptom Manage2007;33. (13)
  10. Cecv G. Preclinical characterization of NSAIDs in ultra deformable carriers or conventional topical gels. International journal of pharmaceutics; 2008.
  11. Yadav SK, Mishra MK, Tiwari A, Shukla A. Emulgel: a new approach for enhanced topical drug delivery. Int J Curr Pharm Res. 2016;9(1):15-9.
  12. Panwar A, Upadhyay N, Bairagi M, Gujar S, Darwhekar G, Jain D. Emulgel: A review. Asian J Pharm Life Sci. 2011; 2231:4423.
  13. Hardenia A, JayroniaS. Emulgel: An emergent toll in topical drug delivery. Int J Pharm Sci Res 2014; 5:1653-60.
  14. Kalia YN, Guy RH. Modeling transdermaldrugrelease.AdvDrugDelivRev.2001,48:159-72.
  15. Ayub,CA,GomesADM,LimaMVC,Vianna- Soares CD,FerreiraLMA. TopicalDeliveryofFluconazole:InVitroSkinPenetration and Permeation Using EmulsionsasDosageFormsDrug.Dev.Ind.Pharm.2007;33:273-280.
  16. Pathan, I.B.; Setty, C.M. Chemical penetration enhancers for transdermal drug delivery systems. Trop J Pharm Res, 8:173 -179, (2009).
  17. Yadav S, Mishra M, Tiwari A, Shukla A. Emulgel: A novel approach for enhanced topical drug delivery. Int J Curr Pharm Res 2017; 9:15-9.
  18. More S, Nandgude T, Poddar S. Vesicles as a tool for enhanced topical drug delivery. Asian J Pharm 2016;10: S196-209.
  19. Ashara K, Shah K. Emulgel: A novel drug delivery system. J Prev Alzheimer’ Dis 2016; 26:243-9.
  20. GaurPK,MishraS,PurohitS,DaveK.TransdermalDrugDeliverySystem:AReview.AJPCR2009;2:14-20.
  21. SubranayamN,GhosalSK,MoulikSP.Enhanced In Vitro Percutaneous Absorptionand In Vivo Anti-Inflammatory Effect of aSelectiveCyclooxygenaseInhibitorUsingMicroemulsion.DrugDev.andIndustrialPharm.,200
  22. Jain NK, 2004. Progress in controlled and novel drug delivery st systems. New Delhi: CBS publishers and distributors, 1, pp 319-20.
  23. Jain S K, Bajapi P, Modi S K, Gupta P, ‘A Review on Emulgel, as a Novel Trend in Topical Drug Delivery’, Recent Trends in Pharmaceutical Sciences and Research, MAT Journal, 2019, 1 (2), 31-21.
  24. Djordjevic J, Michniak B, Uhrich, Kathryn EAAPS PharmSciTech2003;5(4):1-12.
  25. Lachman, L.; Lieberman, H.A. The Theoryand Practice of Industrial Pharmacy. 3rd Ed.VarghesePublishinghouse;1990.pp.534.
  26. Vyas,S.P.;Khar,R.K.ControlledDrugDelivery. 1st Ed. Vallabh Prakashan; 2002.pp.416-417.
  27. BonacucinaG,CespiM,PalmieriGF.CharacterizationandStabilityofEmulsionGelsBasedonAcrylamide/SodiumAcryloyldimethyl Taurate Copolymer AAPSPharmSciTech.June2009;10 (2).
  28. Haneefa KM, Easo S, Hafsa PV, Mohanta GP, Nayar C. Emulgel: An advanced review. Journal of pharmaceutical sciences and research. 2013 Dec 1;5(12):254.
  29. CurrAEB.TransdermalDrugDelivery:PenetrationEnhancementTechniquesHeather.DrugDeliv. 2005;2:23-33.
  30. RutrerN.Drugabsorptionthroughtheskin:amixedblessing.ArchDisChild1987;62:220-221.
  31. Zhang XL, Zhao R, Qian W. Preparation ofan emulgelfor treatmentof aphthousulceron the basis of carbomers. Chin. Pharm. J.1995;30:417-418.
  32. Swarbrick,J.Encyclopediaofpharmaceuticaltechnology,3rd ed.,1551.
  33. Gibson, M. Pharmaceutical formulation andpreformulation,Interpharm 2004.
  34. MortazaviSA,AboofazeliR.AnInvestigationintotheEffectofVariousPenetrationEnhancersonPercutaneous Absorption of Piroxicam. Iranian Journal ofPharmaceuticalResearch2003;135-140.
  35. Kasliwal N, Derle D, Negi J, Gohil J. Effect of permeation enhancers on the release and permeationkinetics of meloxicam gel formulations through rat skin. Asian Journal of Pharmaceutical Sciences 2008, 3 (5): 193-199
  36. Patel RP, Patel G, Baria A: Formulation and evaluation of transdermal patch of aceclofenac. Int. J. Drug Del. 2009; 1: 41 – 51.
  37. R. Barreiro-Iglesias, C. Alvarez-Lorenzo, A. Concheiro, Controlled release of estradiol solubilized in carbopol/surfactant aggregates, J. Control. Release 93(2003) 319–330.
  38. Perioli L, Ambrogi V, Venezi L, Giovangoli S, Panago C: Formulation studies of benzydamine mucoadhesive formulations for vaginal administration. Drug Dev. Ind. Pharm2009; 35:769–779.
  39. Deveda P, Jain A, Vyas N, Khambete H, Jain S: Gellified emulsion for sustained delivery of itraconazole for topical fungal diseases. Int. J. Pharm. Pharm. Sci. 2010; 2: 104–112.
  40. Khullar R, Kumar D, Seth N, Saini S: Formulation and evaluation of mefenemic acid emulgel for topical delivery. Saudi Pharm. J. 2011: 63–67.
  41. Mohamed MI: Optimization of chlorphenesin emulgel formulation. AAPS Pharm. Sci. Technol. 2004; 6:534–542.
  42. El-Setouhy DA, El-Ashmony SM: Ketorolac trometamol topical formulations: release behaviour, physical characterization, skin penetration, efficacy and gasteric safety. J. Pharm. Pharmacol.2010; 62: 25–34.
  43. Shahin M, Hady SA, Hammad M, Mortada N: Novel jojoba oil-based emulsion gel formulations for clotrimazole delivery. AAPS Pharm. Sci. Technol.2011; 12: 239–247.
  44. Shokri J, Azarmi S, Fasihi Z: Effect of various penetration enhancers on percutaneous absorption of piroxicam from emulgel.Res. Pharm. Sci.2012; 7:225–2234.
  45. Perioli L, Panago C, Mazzitelli S: Rheological and functional characterization of new anti-inflammatory delivery system designed for buccal administration. Int. J. Pharm. 2008; 356: 19–28.
  46. Gennaro AR. Ed. Remington: The Science and Practice of Pharmacy, Easton Mack Publishing Company. 1995, 842.
  47. Shingade GM, Aamer Q, Sabale, Grampurohit ND, Gadhave MV: Review on recent trend on transdermal drug delivery system. J. Drug Dev. Ther.2012; 2 (1): 66–75.
  48. Baibhav J, Singh G, Rana A C, Saini S, Singla V: Emulgel: A comprehensive review on recent advancement on topical drug delivery. IRJP, 2011; 2(11): 66-70.
  49. Aher S. D, Banerjee S. K, Gadhave M. V, Gaikawad D. D: Emulgel: a new dosage form for topical drug delivery.IJIPLS. 2013; 3(3): 1-10.
  50. Singh J, Gupta S, Kaur H. Prediction of in vitro drug release mechanisms from extended-release matrix tablets using SSR/R2 technique. Trends in applied science research 2011;6(4) :400-409.
  51. Kumar D, Singh J, Antil M, Kumar V. Emulgel-novel topical drug delivery system-a comprehensive review. International journal of pharmaceutical sciences and research. 2016 Dec 1;7(12):4733.
  52. Husain, Imran Husain Ahmad and Vikrant P. Wankhade. “EMULGEL: MODERN TOOL FOR TOPICAL DRUG DELIVERY.” (2020).
  53. Singla V, Saini S, Joshi B, Rana AC. Emulgel: A new platform for topical drug delivery. International Journal of Pharma and Bio Sciences. 2012;3(1):485-98.
  54. Sultana S, Parveen P, Rekha M, Deepthi K, Ch. Sowjanya, Dr. S Devi. Emulgel- A Novel Surrogate Approach for Transdermal Drug delivery System. Indo-Am. J Pharm. Res, 2014; 4(11): 5350-5265.
  55. WBSaundersCo.Philadelphia,1970,55-60.
  56. GondaliyaDP and Pundarikakshudu K. Indiandrugs,39:465-473,2002.
  57. Chaudhari P, Ajab A, Malpure P, Kolsure P,SanapD,Development,andin-vitroevaluationofthermoreversiblenasalgelformulations of Rizatriptan benzoate, IndianJ.Pharm. Edu.Res., 2009;43: 55-62.
  58. MasmoudiH,PiccerelleP,LeDréauY,Kister J.Arheologicalmethodtoevaluatethephysicalstabilityofhighlyviscouspharmaceuticaloil-in-wateremulsions.PharmRes 2006;23 8:1937–47.
  59. Tadros TF, Future developments in cosmeticformulations. Int J Cos Sci 1992; 14 (3): 93-111

Photo
Navneet Kumar Verma
Corresponding author

Buddha Institute of Pharmacy, Gida, Gorakhpur, UP, India-273209

Photo
Pragya Mishra
Co-author

Buddha Institute of Pharmacy, Gida, Gorakhpur, UP, India-273209

Photo
Shweta Yadav
Co-author

Buddha Institute of Pharmacy, Gida, Gorakhpur, UP, India-273209

Photo
Ravindra Singh
Co-author

Buddha Institute of Pharmacy, Gida, Gorakhpur, UP, India-273209

Photo
Sushil Kumar Tiwari
Co-author

Buddha Institute of Pharmacy, Gida, Gorakhpur, UP, India-273209

Navneet Kumar Verma*, Pragya Mishra, Shweta Yadav, Ravindra Singh, Sushil Kumar Tiwari A Brief Review On Emulgel: Recent Advances, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 559-570. https://doi.org/10.5281/zenodo.10213426

More related articles
Formulation Development and Evaluation of Herbal C...
Khandagale. S. S, Salve Dvitiya S, Dabhade Sakhi K., Madane Samna...
Development And Validation Of UV Spectroscopy For Determination Of Linagliptin I...
Reshma Dhakate, Sachin Zende, Sakshi Renge, Jaydeep Pawar, Vikas Pawar, Nitin Salve, ...
Determination Of Etoricoxib By Analytical And Bioanalytical Methods: A Review...
Shweta Vinayak Rane, Sapan K. Shah, Dinesh R. Chaple, Mayur A. Lohi, Pooja R. Denge, Sahil D. Gayakw...
A Review on the Microbiology of the Animal Bite Wound Infection ...
Shrikant Gadgade, Laxmiprasad Khochage, Nilesh Chougule, Sahil Agrawal, ...
Related Articles
Formulation And Evaluation Of Herbal Anti-Bacterial Crack Heel Ointment Using Th...
Ms.Priyanka Raut, Mrs.Manisha Mishra, Gayatri Bawane, Ayushi Ambade, Alshapha Anjum Khan, Abhilasha ...
Formulation And Evaluation Of Resorcinol Gel With Rose Extract For eczema...
Prerana Sahu, Radha Rani Verma, Dr. Gyanesh Sahu , Dr. Harish Sharma , ...
Recent Advances And Emergency Trends In Anticoagulant Therapy...
Bhavani Suba Niranjana, Julliyan Dilleban , Deephiha Elango, Balakrishnan karuppiah, ...
Leucas aspera And Its Economic Importance: A Review...
Shanmugavadivu Muthusamy, Dhanalakshmi Karuppasamy, Niveda Kannappan, ...
Formulation Development and Evaluation of Herbal Candy Containing Lantana Camara...
Khandagale. S. S, Salve Dvitiya S, Dabhade Sakhi K., Madane Samnath J. , Mahalkar Ram B. , Patil Omk...