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Abstract

The development and validation of a UV spectroscopy method for determining Imeglimin Hydrochloride in tablet formulation. The method utilized distilled water as a solvent and a detection wavelength of 237 nm. It was validated following ICH guidelines and demonstrated good linearity within a concentration range of 2-10 µg/mL (r2=0.9991). The method exhibited precision with low RSD values (<2%) and sensitivity with LOD and LOQ values of 16.74 µg/mL and 50.73 µg/mL, respectively. The method also showed good recovery values, indicating the absence of interferences. It was successfully applied for the determination of Imeglimin Hydrochloride in tablets. In conclusion, the UV spectrophotometric methods developed and validated in this study were found to be accurate, precise, and sensitive. Their cost-effectiveness and minimal maintenance make them suitable for use in small-scale industries where economy and time are crucial for quality control and therapeutic efficacy assurance.

Keywords

Imeglimin Hydrochloride, antidiabetic, type 2, UV-Vis spectroscopy.

Reference

  1. Sapra A, Bhandari P. Diabetes. [Updated 2023 Jun 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551501/
  2. Ashutoshkar, Pharmaceutical Analysis (Vol-II), CBS publisher and distributors, first  edition;2009:252-8
  3. V.M Parikh., Absorption spectroscopy of organic molecules, chapter 2., Wesley Publishing Co., ReadingM.A;1974:155-8.
  4. B.K. Sharma., Spectroscopy, eleventh edition, GOEL Publishing House, Meerut;1995,7-10
  5. Validation of analytical P text and methodology Q2(R1). https://database.ich.org/sites/default/files/Q2_R1__Guideline.pdf.
  6. Ajay Sanjay Salvi., et al., (2023) reported Development and Validation of RP-HPLC Method for Estimation of Anti-Diabetic Drug in Bulk and Tablet Dosage Form.
  7. Avnish Jain., et al., (2023) reported Development And Validation Of Stability Indicating Rp-Uhplc Method For The Estimation Of Imeglimin Hydrochloride Used For The Treatment Of Metabolic Disorder Diabetes Mellitus
  8. Sangamithra Ramalingam., et al., (2023) A Sensitive Direct Chiral Liquid Chromatography Tandem Mass Spectrometry Method For The Enantio—Selective Analysis Of Imeglimin In Formulation
  9. National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 24812808, Imeglimin. from https://pubchem.ncbi.nlm.nih.gov/compound/Imeglimin.

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Tamil Selvan R
Corresponding author

Associate Professor, Department of Pharmaceutical Analysis, Arunai College of Pharmacy, Tiruvannamalai,Tamil Nadu 606603

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Senthilkumar S K
Co-author

Principal cum Professor, Arunai College of Pharmacy, Tiruvannamalai, Tamil Nadu 606603

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HARI PRAKASH G
Co-author

Students, Arunai College of Pharmacy, Tiruvannamalai, Tamil Nadu 606603

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Elakkiya A.
Co-author

Students, Arunai College of Pharmacy, Tiruvannamalai, Tamil Nadu 606603

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Gayatri M.
Co-author

Students, Arunai College of Pharmacy, Tiruvannamalai, Tamil Nadu 606603

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Gokulraj M.
Co-author

Students, Arunai College of Pharmacy, Tiruvannamalai, Tamil Nadu 606603

Photo
Hajima H.
Co-author

Students, Arunai College of Pharmacy, Tiruvannamalai, Tamil Nadu 606603

Tamil Selvan R.*, Senthilkumar S. K., Elakkiya A., Gayathri M., Gokulraj M., Hajima H., Hari Prakash G., A Novel Method Development And Validation Of Imeglimin HCl By Uv-Visible Spectroscopy, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 12, 852- 859. https://doi.org/10.5281/zenodo.10433883

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