Assessment And Evaluation of Black Cumin Seeds Tablet for Various Pharmacological Activity

Black cumin seeds (Nigella sativa) been used in traditional medicine for centuries due to their Wide range of therapeutic properties.Their pharmacological activities are attributed to the presence of bioactive compounds, such as Thymoquinone, alkaloids, saponins and essential fatty acids, among others. These compounds contribute to a wide range of medicinal benefits, including, antioxidant, anti-inflammator, Antimicrobial, hay fever, digestive aid, cardioprotective antidiabetic, and anticancer effects.[1] In addition to the pharmacological testing, it is essential to assess the physical and chemical Properties of the Black Cumin seed tablets. With increasing interest in herbal medicine, Black Cumin seed tablets have gained popularity as a convenient dosage form to deliver these beneficial compounds.

These tablets offer a convenient way to support overall wellness. Traditionally used in various cultures for boosting immunity, improving digestion, and promoting respiratory health, Black Cumin Seeds Tablets are now gaining global recognition as a holistic addition to daily health routines. Whether you’re looking to enhance your natural defenses or support metabolic balance, this supplement brings centuries of herbal wisdom into modern health practices. When formulated into tablet form, black cumin seeds provide a convenient way to access these benefits in a concentrated dose.[2] Tablets are the solid dosage form containing medicament or medicaments, usually circular in shape and may be flat or biconvex tablets are prepared by the compression method and hence call the compressed tablet.

1.2 Advantages of Tablet

1. They are easy to be dispensed.
2. These are more stable dosage form.
3. They maintain the accuracy of dosage.
4. Bitter and nauseous substances can be given easily in tablet form after giving a suitable coating to the tablets.
5. They are the lightest and the most compact of all dosage forms.
6. Of all the dosage form, tablets are easiest and the cheapest as regard packing and transport.
7. They are better suited to a large-scale production as compared with any other unit oral dosage form.

1.3 Disadvantages of Tablet

1. Some drugs resist compression into tablet form due to their amorphous nature or low-density character.
2. Bitter tasting drugs, drugs with objectionable odour or drugs that the sensitive to oxygen or atmospheric moisture may require encapsulation or a special type of coating which may increase the cost of the finished tablets.
3. Drugs with poor wetting and slow dissolution properties are difficult to convert into tablets which provide full drug bioavailability.
4. The tablets cannot be used in case of emergency cases, because the rate at which active ingredient reaches the site to be treat slow.
5. Bioavailability of some drugs may be low due to poor absorption from the gastric tract.

PLANT PROFILE

1. Black Cumin seeds

Fig.no.1 Black cumin Seeds

Fig.no.2 Black Cumin Seeds Powder

Health Benefits of Black Cumin Seeds

1. Anti-inflammatory properties: Thymoquinone, the main active compound in black cumin seeds, has strong anti-inflammatory effects, which may help with conditions like arthritis or asthma.
2. Antioxidant effects: These seeds help neutralize harmful free radicals in the body, potentially lowering the risk of chronic diseases.
3. Boosts immune system: Regular use may enhance immune function, helping the body fight off infections.[5]
4. Supports heart health: They may help reduce blood pressure, lower cholesterol levels, and improve blood lipid profiles.
5. Regulates blood sugar: Some studies show black cumin seeds can help maintain healthy blood glucose levels, which is beneficial for people with diabetes.
6. Antimicrobial and antifungal: They exhibit antibacterial and antifungal effects, potentially helping treat infections like Candida.
7. Digestive health: Traditionally used to relieve bloating, indigestion, and gas.
8. Supports liver function: May protect the liver from toxins and support its overall function.
9. Skin and hair benefits: Applied topically or taken as oil, it may help with acne, eczema, and promote hair growth.[6]

2. Ginger

  Fig.no.3 Ginger                      Fig.no. 4 Acacia                            Fig.no. 5 lactose

 Fig.no.6 Magnesium Stearate            Fig.no. 7 Starch                            Fig.no. 8 Talc

PRE-FORMULATION STDIES

1. 1. Angle of repose: Angle of repose is defined as the maximum angle possible between the Surface of pile of powder and the horizontal plane, Tan θ = h/r.

Angle of Repose: By using Formula, Θ= tan ¹h/r

H= 3cm, r= 4cm Θ = Tan-1 ¾ ,

= Tan-1(0.75).

1. 2. Bulk Density: Bulk density of a powder is defined as the ratio of the mass of the powder and its bulk volume.[10]

Bulk density:

M= 10gm,

V=30ml Formula using,

Bulk density= mass of powder/ bulk volume

= 10/30

= 0.33

1. 3. Tapped density: The tapped density is an increased bulk density attained after mechanical Tapping of container the sample. The inter particular interaction influence bulking properties and Interface with powder flow.

Tapped density M= 10gm, Vo=22ml Formula using, Tapped density= mass of powder/ tapped volume

= 10/22

=0.45

1. 4. Porosity: whether the powder is porous or non-porous the total porosity expression for the calculation Remains Same. The percent porosity is Express as % porosity = (bulk volume- tapped volume) x100/ bulk Volume.

Porosity Formula using,

%porosity = (bulk volm – tapped volm) ×100/ bulk volume

= 30-22/30 X100

= 33.33%

1. Carr’s Index: Carr’s Index an indication of the compressibility of powder. It is calculated by The Formula:

Carr’s index = tapped density -bulk density /tapped density x100 Corr’s using Index & Formula,[12]

Carr’s Index = tapped density – bulk density/ tapped density

= 0.45 0.45 26.66% 0.33 ×100

= 26.66%

2. Hausner Ratio: The Hauser Ratio is a number that is correlated to the flowability of a powder or Granule material. The Hausner Ratio is calculated by the Formula,[13]

H = ?T/?B Where,

?B= bulk density of the powder.

?T= tapped density of the powder. Hausner Ratio:

H= ?T/?B

= 0.45/ 0.33

= 1.36

MATERIALS AND METHODS

Table no. 3. Formulation Table

RESULT AND DISCUSSION

Generally herbal preparations are known for its “No side effect” property. The results of this Project are that formulation and of black Cumin seeds Tablet perform Successfully.

Table no.4. Result and Discussion