View Article

  • Comparative Study Of Antihypertensive Drug Between Nifedipine, Carvedilol And Methyldopa In Emergency Condition

  • 1UG Scholar student of Rashtriya college of Pharmacy Hatnoor, Tq. Kannad,Dist. Chh. Sambhajinagar Maharashtra, India -431103
    2Assistant professor of  Rashtriya college of Pharmacy Hatnoor, Tq. Kannad , Dist.Chh.Sambhajinagar Maharashtra India -431103.
    3UG Scholar student of Rashtriya college of Pharmacy Hatnoor, Tq.Kannad Dist. Chh.Sambhajinagar Maharashtra, India -431103
     

Abstract

Throughout the world, hypertension affects billions of individuals. It dramatically raises the risk of heart attacks, heart death, and kidney issues. A number of medication classes are available to assist healthcare providers and their patients in controlling hypertension. Worldwide, more than 1 billion people live with the chronic illness known as hypertension. The Framingham Heart Study revealed that even individuals with normal blood pressure (BP) at age 55 had a 90% lifetime risk of developing hypertension. This is because the likelihood of developing hypertension increases with age. In an emergency involving hypertension, nifedipine, methyldopa, and carvedilol are recommended as first-line treatments for preeclampsia. To determine which drug is the least expensive and has the fewest side effects, more study is needed to assess the effectiveness of various treatments. This study examined the efficacy of different drugs in lowering blood pressure in cases of hypertension.

Keywords

Hypertension, Nifedipine, Methyldopa , Carvedilol and comparison of the three drugs’ pharmacokinetics.

Reference

  1. Khan KM, Patel JB, Schaefer TJ. Nifedipine. 2023 May 23. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 30725737.
  2. Ruffolo RR Jr, Gellai M, Hieble JP, Willette RN, Nichols AJ. The pharmacology of carvedilol. Eur J Clin Pharmacol. 1990;38 Suppl 2:S82-8. Doi: 10.1007/BF01409471. PMID: 1974511.
  3. Snider ME, Nuzum DS, Veverka A. Long-acting nifedipine in the management of the hypertensive patient. Vasc Health Risk Manag. 2008;4(6):1249-57. Doi: 10.2147/vhrm.s3661. PMID: 19337538; PMCID: PMC2663456.
  4. Mah GT, Tejani AM, Musini VM. Methyldopa for primary hypertension. Cochrane Database Syst Rev. 2009 Oct 7;2009(4):CD003893. Doi: 10.1002/14651858.CD003893.pub3. PMID: 19821316; PMCID: PMC7154320.
  5. Gupta M, Al Khalili Y. Methyldopa. [Updated 2023 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551671/
  6. Singh S, Preuss CV. Carvedilol. 2023 Mar 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls    Publishing; 2023 Jan–. PMID: 30521289.
  7. Raemsch KD, Sommer J. Pharmacokinetics and metabolism of nifedipine. Hypertension. 1983 Jul-Aug;5(4 Pt 2):II18-24. Doi: 10.1161/01.hyp.5.4_pt_2.ii18. PMID: 6862586.
  8. Nifedipine oral Route
  9. Easterling T, Mundle S, Bracken H, Parvekar S, Mool S, Magee LA, von Dadelszen P, Shochet T, Winikoff B. Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial. Lancet. 2019 Sep 21;394(10203):1011-1021. Doi: 10.1016/S0140-6736(19)31282-6. Epub 2019 Aug 1. PMID: 31378394; PMCID: PMC6857437.
  10. S D, Novri DA, Hamidy Y, Savira M. Effectiveness of nifedipine, labetalol, and hydralazine as emergency antihypertension in severe preeclampsia: a randomized control trial. F1000Res. 2023 Apr 27;11:1287. Doi: 10.12688/f1000research.125944.2. PMID: 37273965; PMCID: PMC10238817.
  11. Methyldopa –use,  side effect , and more .
  12. Singh S, Shankar R, Singh GP. Prevalence and Associated Risk Factors of Hypertension: A Cross-Sectional Study in Urban Varanasi. Int J Hypertens. 2017;2017:5491838. Doi: 10.1155/2017/5491838. Epub 2017 Dec 3. PMID: 29348933; PMCID: PMC5733954.
  13. Familoni BO, Ogun SA, Aina AO. Knowledge and awareness of hypertension among patients with systemic hypertension. J Natl Med Assoc. 2004 May;96(5):620-4. PMID: 15160976; PMCID: PMC2640651.
  14. Kleinbloesem CH, van Brummelen P, van de Linde JA, Voogd PJ, Breimer DD. Nifedipine: kinetics and dynamics in healthy subjects. Clin Pharmacol Ther. 1984 Jun;35(6):742-9. Doi: 10.1038/clpt.1984.105. PMID: 6734025.

Photo
Amey Gangalwar
Corresponding author

UG Scholar student of Rashtriya college of Pharmacy Hatnoor, Tq.Kannad Dist. Chh.Sambhajinagar Maharashtra, India -431103

Photo
Suresh waghmare
Co-author

Assistant professor of Rashtriya college of Pharmacy Hatnoor, Tq. Kannad , Dist.Chh.Sambhajinagar Maharashtra India -431103.

Photo
Payal Durole
Co-author

UG Scholar student of Rashtriya college of Pharmacy Hatnoor, Tq.Kannad Dist. Chh.Sambhajinagar Maharashtra, India -431103

Gangalwar A. M., Waghamare S. U., Durole P. Y. , Comparative Study Of Antihypertensive Drug Between Nifedipine, Carvedilol And Methyldopa In Emergency Condition, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 554-561. https://doi.org/10.5281/zenodo.10559434

More related articles
Assessment and Pharmacovigilance of Drug-Drug Inte...
Raja Waleed Sajjad, Huma Tanveer, Ahmad Nawaz, Saba Manzoor, Syed...
Candesartan Cilexetil: A Review of its Pharmacolog...
Jignesh Parmar, Dr. Khushbu Patel, Dr. Pruthviraj Chaudhary, Dr. ...
Adverse Drug Reactions To Anti-Hypertensive: A Hos...
Sonal Kumbhar , Ayan Noushad Sayyad , Nilesh Chougule , ...
Nebivolol: A Beta Blocker with A Twist - A Review of Its Distinctive Properties...
Pawar Sarika, Dr. Jha Urmilesh, Dr. Mansuk Avinash , Padekar Chetana , Pawar Aniket , Shinde Shradha...
Cilnidipine And Risk Factors For Dementia Associated Parkinsonism – A Case Rep...
Dhanya Dharman, Silpa Siva Prasad, Anfi D. P, Shaiju S Dharan, ...
Candesartan Cilexetil: A Review of its Pharmacology and Therapeutic Uses ...
Jignesh Parmar, Dr. Khushbu Patel, Dr. Pruthviraj Chaudhary, Dr. C. N. Patel, ...
Related Articles
Natural Hypertension Remedies: A Review of Medicinal Plant Efficacy...
Dr. Payal Vaja, Hiral Popaniya, Dilip Ghusar, Vivek Solanki, Siddhi Upadhyay, Harsh Madiya, ...
A Review Article On Transdermal Patches Of Atenolol For Management Of Hypertensi...
Saniya Ikra Khan, Vikas Jain, Narendra Gehalot, Anjali Chourasiya, ...
Analytical Methods Review on Anti-Hypertensive Drug: CANDESARTAN (CAND)...
Nikita Sonawane , Ritik Ahire, Mayur Chavan, Vinod Chaure, Ravindra Patil, ...
Candesartan Cilexetil: A Review of its Pharmacology and Therapeutic Uses ...
Jignesh Parmar, Dr. Khushbu Patel, Dr. Pruthviraj Chaudhary, Dr. C. N. Patel, ...
Assessment and Pharmacovigilance of Drug-Drug Interactions in Hypertension: A Re...
Raja Waleed Sajjad, Huma Tanveer, Ahmad Nawaz, Saba Manzoor, Syeda Fatima Ashoor, Raja Ahmed, ...
More related articles
Assessment and Pharmacovigilance of Drug-Drug Interactions in Hypertension: A Re...
Raja Waleed Sajjad, Huma Tanveer, Ahmad Nawaz, Saba Manzoor, Syeda Fatima Ashoor, Raja Ahmed, ...
Candesartan Cilexetil: A Review of its Pharmacology and Therapeutic Uses ...
Jignesh Parmar, Dr. Khushbu Patel, Dr. Pruthviraj Chaudhary, Dr. C. N. Patel, ...
Adverse Drug Reactions To Anti-Hypertensive: A Hospital Survey Pharmacovigilance...
Sonal Kumbhar , Ayan Noushad Sayyad , Nilesh Chougule , ...
Assessment and Pharmacovigilance of Drug-Drug Interactions in Hypertension: A Re...
Raja Waleed Sajjad, Huma Tanveer, Ahmad Nawaz, Saba Manzoor, Syeda Fatima Ashoor, Raja Ahmed, ...
Candesartan Cilexetil: A Review of its Pharmacology and Therapeutic Uses ...
Jignesh Parmar, Dr. Khushbu Patel, Dr. Pruthviraj Chaudhary, Dr. C. N. Patel, ...
Adverse Drug Reactions To Anti-Hypertensive: A Hospital Survey Pharmacovigilance...
Sonal Kumbhar , Ayan Noushad Sayyad , Nilesh Chougule , ...