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  • Design, Synthesis and Pharmacological Evaluation of Novel Pyrimidine Derivatives as Antihyperlipidemic Agents
  • 1Ph.D. Research scholar, Pacific Academy of Higher education and Research University, Udaipur, Rajasthan.
    2Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule, Dist. Dhule, MS.
    3Pacific Academy of Higher education and Research University, Udaipur, Rajasthan.
    4Shri Gulabrao Deokar Institute of Pharmacy & Research Center, Jalgaon, Dist. Jalgaon, MS.

Abstract

Hyperlipidemia is a prevalent medical condition characterized by elevated levels of lipids, including cholesterol and triglycerides, in the bloodstream. This condition poses a significant risk factor for cardiovascular diseases due to the accumulation of fatty deposits in arteries. Genetic, lifestyle, and dietary factors contribute to its development. Diagnosis involves measuring lipid levels, and management typically includes lifestyle changes and medications. Pyrimidine derivatives, on the other hand, are essential organic compounds with a six-membered heterocyclic ring structure containing carbon and nitrogen atoms. These derivatives play a vital role in genetics and biochemistry. In DNA and RNA, pyrimidine bases such as cytosine, thymine, and uracil form complementary base pairs with purines, facilitating the storage and transmission of genetic information. They are also involved in metabolic pathways, including de novo pyrimidine biosynthesis and salvage pathways. The importance of pyrimidine derivatives extends beyond genetics. Their structural versatility has led to their use as fundamental scaffolds in pharmaceutical compounds. Several drugs, such as anticancer agents and antiviral medications, are derived from the pyrimidine core structure, demonstrating its significance in medicine and drug development. It highlights the interplay between hyperlipidemia, a condition affecting cardiovascular health, and pyrimidine derivatives, crucial components of genetics and biochemistry. Understanding both aspects contribute to advancing medical knowledge and therapeutic strategies, addressing critical health concerns and enabling pharmaceutical innovation.

Keywords

Pyrimidine, Docking, Modeling, Synthesis, Hyperlipidemic

Reference

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Avinash Patil
Corresponding author

Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule, Dist. Dhule, MS

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Prashant Chavan
Co-author

Ph.D. Research scholar, Pacific Academy of Higher education and Research University, Udaipur, Rajasthan

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Amitkumar Rawal
Co-author

Pacific Academy of Higher education and Research University, Udaipur, Rajasthan

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Kiran Patil
Co-author

Shri Gulabrao Deokar Institute of Pharmacy & Research Center, Jalgaon, Dist. Jalgaon, MS

Prashant Chavan, Avinash Patil*, Amitkumar Rawal, Kiran Patil, Design, Synthesis and Pharmacological Evaluation of Novel Pyrimidine Derivatives as Antihyperlipidemic Agents, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 55-65. https://doi.org/10.5281/zenodo.8321784

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