Ph.D. Research scholar, Department of Pharmacology, Sri Adichunchanagiri College of Pharmacy, B.G. Nagara-571448, Karnataka, India
Dean of pharmacy & Professor, Department of Pharmacology, Sri Adichunchanagiri college of pharmacy, B.G. Nagara-571448, Karnataka, India
Age-related Cognitive impairment is a common issue that is frequently brought on by oxidative stress and neurodegeneration in the brain. Material & methods: Benincasa hispida, commonly known as wax gourd, is widely used as a vegetable with various medicinal properties. it belongs to the family of Cucurbitaceae. The study evaluates the cognitive role of a hydro-ethanolic seed extract of Benincasa hispida (BH) against D-gal-induced in aged rats. Old male rats were divided into six groups: The control group received normal saline, donepezil (2 mg/kg b.w.t., i.p.); D-gal (300 mg/kg b.w.t., i.p.); D-gal +BH (150 mg/kg b.w.t., o.p.); D-gal BH (250 mg/kg b.w.t., o.p.); and D-gal BH (300 mg/kg b.wt. Results and Discussion: The behavioral study depicted that D-gal significantly alters locomotor activity. Biochemical studies showed that D-gal significantly increases oxidative stress in rat brains. Histopathological study showed that D-gal disturbs the normal architecture of hippocampal and cortical cells, indicating degeneration in these brain areas. D-gal and BH co-treatment for 42 days attenuated the behavioural, biochemical, and neuroanatomic damages caused by D-gal; it markedly suppressed the D-gal-induced oxidative stress. Conclusion: Thus, this study shows that BH can protect the brain from the adverse effects of D-gal (e.g., memory loss and cognitive impairment) by modulating oxidative stress.
Pooja R. C., Dr. Bharathi D. R, Benincasa Hispida Reversed D-galactose-induced oxidative Stress and neurodegeneration-mediated Cognitive Impairment in Aged Rats, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 10, 150-164. https://doi.org/10.5281/zenodo.10014344