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Abstract

Liver disease is primarily caused by alcohol. The liver, synthesizes proteins, detoxifies a variety of metabolites, and produces a range of biochemical’s required for digestion. Liver inflammation is the ailment known as alcoholic liver disease. Extended periods of excessive alcohol consumption are the cause of it. When consumed in larger doses, alcohol is toxic because it contains polyunsaturated fatty acids (PUFA), which cause oxidative stress, hepatotoxicity. Alcoholic liver disease is a broad term that includes vary in severity from mild steatosis to severe cirrhosis .Over 80%-90% of people who drink on a regular basis and binge drink also have fatty liver. Even though anyone who drinks a lot of alcohol over an extended period of time will eventually develop fatty liver, this process is temporary and can be reversed with prompt treatment. In Ayurveda it can be correlate with Yakritdalyodara or Yakrit Vridhi. The treatment protocol mentioned in ayurveda mainly Nityavirechana for this disease along with various oral medications. In this case study patient was given a combination of Kutaki Churna 3gm and Chirayata Churna 3gm at bed time for Nityavirechana, Chandraprabha Vati 2tab twice daily and Syrp Liv 52 2tsf twice daily. So, Panchkarma procedures along with internal medications show good results in the management of overall symptoms in this case of Yakrit vridhi.

Keywords

Yakrit vridhi, hypatotoxicity, Infiltration, Nityavirechana, Chirayata Churna, Syrup Liv 52, FLD

Reference

  1. Bruha R, Dvorak K, Petrtyl J. (2012). Alcoholic liver disease, World journal of hepatology, 27;4(3):81. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321494/.
  2. Davidson, Principle and practice of medicine, edited by Haslett Christopher, chilvers Edwin R.etal. Ninteenth edition, 2002; 866.
  3. Davidson, Principle and practice of medicine, edited by Haslett Christopher, chilvers Edwin R.etal. Ninteenth edition, 2002; 867.
  4. Shastri SB, editor. Yoga Ratnakar, Commentary by Vaidya Sri Laxmipati Shastri. Udara Rogachikitsa: Ver. 17. Varanasi: Chaukhamba Prakashan; 2009; 104.
  5. Sharma R.K., Dash Bhagwan, Charak Samhita, Chakrapani,vol.3, chowkhamba Sanskrit series office, Varanasi, reprint edition, 2005; 523.
  6. Acharya YT, editor. (2002). Charaka Samhita of Agnivesha, Chikitsa Sthana, Udara ChIikitsa, Chapter 16, verse 7, Rastriya Sanskrit sansthana; New Delhi: reprint,495.
  7. Acharya YT, editor. (2002). Charaka Samhita of Agnivesha, Chikitsa Sthana, Udara ChIikitsa, Chapter 16, verse 10, Rastriya Sanskrit sansthana; New Delhi: reprint;495.
  8. Acharya YT, editor. (2002).Charaka Samhita of Agnivesha, Chikitsa Sthana, Udara ChIikitsa, Chapter 13, verse 36, Rastriya Sanskrit sansthana; New Delhi: reprint;495.
  9. PandeyGS, editor. (2004) Bhavaprakasha Nighantu of Bhavamishra, Guduchyadivarga 10, Choukhamba Bharti Acedemy,Varanasi, 422. ).
  10. Bhattacharjee R., Sil P.C. Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties. Food Chem. Toxicol. 2007;45(5):817–826. doi: 10.1016/j.fct.2006.10.029. [PubMed] [CrossRef] [Google Scholar]
  11. Manjrekar A.P., Jisha V., Bag P.P., Adhikary B., Pai M.M., Hegde A., et al. Effect of Phyllanthus niruri Linn. treatment on liver, kidney and testes in CCl4 induced hepatotoxic rats. Indian J. Exp. Biol. 2008;46(7):514–520. [PubMed] [Google Scholar]
  12. Venkateswaran P.S., Millman I., Blumberg B.S. Effects of an extract from Phyllanthus niruri on hepatitis B and woodchuck hepatitis viruses: in vitro and in vivo studies. Proc. Natl. Acad. Sci. U.S.A. 1987;84(1):274–278. doi: 10.1073/pnas.84.1.274. [PMC free article] [PubMed] [CrossRef] [Google Scholar] 
  13. . Sri Bhavamishra, Bhavaprakash Nighantu, Commentary by K C Chunekar, edited by G S Pandey, Choukamba Bharati Academy, Varanasi: Revised & Enlarged ed. 2010; p. 39-40.
  14. . Sri Bhavamishra, Bhavaprakash Nighantu, Commentary by K C Chunekar, edited by G S Pandey, Choukamba Bharati Academy, Varanasi: Revised & Enlarged ed. 2010; p. 166
  15. Bhatt AD, Bhatt NS Indigenous drugs and liver disease. Indian J Gastroenterol, 1996; 15: 63-67
  16. Thyagarajan SP, Jayaram S,Gopalakrishnan V, Hari R, JeyakumarP, et al. Herbal medicines for liver diseases in India.J GastroenterolHepatol, 2002; 17: S370-S376.
  17. Adewusi EA, Afolayan AJ A review of natural products with hepatoprotective activity. J MedPlants Res., 2010; 4: 1318-1334.
  18. Navaneethan U, Venkatraman J Herbal drugs in liver disease: how safe are they? Eur JGastroenterol Hepatol, 2008; 20: 224-226.) .
  19. Kulkarni DA. Rasa Ratna Samuchchya. 14th edition. New Delhi. Meharchand lachhman das publication, 1998; 94-95.
  20. Singh, R., Gautam, N., Mishra, A., & Gupta, R.(2011). Heavy metals and living systems: An overview. Indian journal of pharmacology, 43(3), 246.).
  21. Latha P, Suja S, et.al., Rajasekharan S, Pushpangadan P. Hepatoprotective effects of
  22. Ixora coccinea flower extract on rats. J Trop Med Plant. 2004 ;4:33-8.
  23. Suja S, Rajasekharan S, Pushpangadan P. Antihepatotoxic activity of Spilanthes ciliata. Pharm Biol. 2003 ;41:536-41.
  24. . Suja S, Latha P, et.al. Assessment of hepatoprotective and free radical scavenging effects of Rhinacanthus nasuta (Linn.) Kurz in Wistar rats. J Nat Rem. 2004;4:66-72.

Photo
Neeraj K. Pathak
Corresponding author

PG Scholar, HOD & Associate Professor, Assistant Professor, PG Department of Panchkarma, PGIA, DSRRAU, Jodhpur, India

Photo
Gyan P. Sharma
Co-author

PG Scholar, HOD & Associate Professor, Assistant Professor, PG Department of Panchkarma, PGIA, DSRRAU, Jodhpur, India

Photo
Achala R. Kumawat
Co-author

PG Scholar, HOD & Associate Professor, Assistant Professor, PG Department of Panchkarma, PGIA, DSRRAU, Jodhpur, India

Neeraj K. Pathak, Gyan P. Sharma, Achala R. Kumawat, Effective Ayurvedic Treatment For Alcohol- Related Liver Dieases- A Case Study, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 279-284. https://doi.org/10.5281/zenodo.10650349

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