S.V.S Institute of Pharmacy, Mungase, at post Malegaon, Nashik
Curcuma longa commonly called as turmeric belongs to the family of Zingiberaceae and it is derived from the rhizomes. It is well known that curcumin has a good anti-inflammatory properties and a protective effect on the skin. Traditionally, curcumin is incorporated in many natural herbal remedies to treat skin infections and inflammation. Stearic Acid, different quantities of Turmeric Extraction, Cetyl alcohol, Propylene Glycol ,glycerine, Methyl Paraben, Vitamin E, Sodium Lauryl Sulphate, Almond oil, and the necessary amount of distilled water were used to produce the cream. The pH of the skin (6.8–7) was then maintained by adding. The prepared compositions were assessed for skin irritation, Spreadability, pH, and physical appearance. Stability investigations have adhered to ICH recommendations. The purpose of this study to isolate curcumin from Curcuma longa and formulate curcumin containing herbal cream. Result: The current work was completed on the formulation and assessment of the herbal cream. A number of factors are taken into consideration when evaluating cream, including its colour, consistency, pH, Spreadability, viscosity, stability, washability, and skin irritancy test results
Turmeric
Turmeric (Curcuma longa) Turmeric is an amazing plant. Its botanical name is Curcuma longa L. and it’s part of the ginger family.1 Turmeric is native to Southwest India, which is where its roots come from. Those roots give turmeric its bright yellow colour - people use turmeric both as a spice and to make dye.2
The use of turmeric rhizome and other plant derivatives that yield yellow-colored colors is becoming more common as a natural compound's synthetic additions are replaced.4 The rhizome of turmeric is frequently used in the food sector, especially as a coloring additive for sauces and processed meals. One of nature's most valuable resources, turmeric is a significant medicinal and fragrant plant with enormous export potential in the areas of natural colors, medicine, personal care, and culinary spices.3-6
The rhizome of turmeric has been used for many years in various applications and has been traded internationally because of its health-promoting qualities. Turmeric's unique yellow-orange color and strong flavor profile have made it a valuable ingredient in international culinary supply chains and business opportunities.8-9
Fig no.1 Curcuma Longa
Fig. no. 2 Plant of Curcuma Longa
Scientific Classification of curcuma longa:4
Chemical Constituent’s
One of the many bioactive components found in turmeric, which is well known for its health benefits, is curcumin, which makes up between 2 and 5% of the plant's weight.7 Strong anti-inflammatory characteristics set curcumin apart, which makes it an invaluable treatment for ailments like arthritis. Its antioxidant properties also protect cells from the damaging effects of free radicals, and its ability to prevent the formation of cancer cells and improve brain function only serves to increase its appeal. Smaller concentrations of demethoxy curcumin (DMC) and bisdemethoxy curcumin (BDMC) have comparable benefits, especially in reducing inflammation and preventing cancer.
About 30% of the essential oil fraction is composed of turmerone, which has antibacterial, neuroprotective, and anti-inflammatory qualities. Curlone has strong antibacterial and anti-inflammatory properties and makes about 12–15% of the essential oil fraction. Finally, curcuphenol, while in minute concentrations, adds to the antibacterial and anti-inflammatory properties of turmeric. When combined, these substances highlight turmeric's diverse range of medicinal benefits for a number of ailments.8-10
Table.2: Biological activities of turmeric compounds and extract. 5-10
Cream:
Emulsifying agents stabilize the water and oil phases of creams, which are semi-solid emulsions. They are applied topically for medicinal, cosmetic, and skincare uses. Creams are semisolid dosage forms containing more than 20% water or volatile components and typically less than 50% hydrocarbons, waxes, or polyols as vehicles. Additionally, they might have one or more medication ingredients dissolved or spread throughout an appropriate cream foundation. This phrase has historically been used to describe semisolids with a somewhat fluid viscosity that are prepared as oil-in-water (such as fluocinolone acetonide cream) or water-in-oil (such as cold cream) emulsions.12-14
APPLICATIONS OF HERBAL CREAMS11
ADVANTAGES: 11
MATERIAL AND METHODS:
Material:
Curcuma Longa extract was collected. The plant materials were authenticated at the P.G. Department of botany and research centre, MSG arts, science and commerce college, Malegaon camp, Nashik by Dr. Atul N. Wagh. The stearic acid, glycerine, cetyl alcohol, methyl paraben, propylene glycol, vit-E, sod.lauryl sulphate, almond oil and distilled water were obtained from the Department of Pharmaceutics, SVS IOP.
Methods:
Preparation of Turmeric extract: 15
Curcuma longa (turmeric) extract was made with great care and attention to detail. Peeled or unpeeled turmeric had been acquired, and solvent mixes (propylene glycol and water, butylene glycol and water, and glycerin and water) had been made. The chosen solvent mixture was added to an extraction vessel containing the turmeric, and the extraction method employed was maceration. Grain alcohol and powdered turmeric peel were used to create a hydro-alcoholic extraction process for the extract. After the combinations were filtered to get rid of leftovers, the turmeric extract was gathered. Lastly, the extract was properly stored and, if necessary, concentrated or purified. Temperatures, maceration durations, and solvent ratios have all been meticulously modified to satisfy particular specifications.
Fig.no.04: 1st day
fig.no.05: Extraction Process
fig.no.06: filter extract
Formulation of herbal cream: 16
Fig.no.07: formulation of cream
Table 1: cream base formulation
PHYSICAL EVALUATION PARAMETER17-19
The following criteria were used to assess herbal cream:
The organoleptic properties such as colour, Odor and appearance were observed.
The pH value of freshly formulated emulsion was determined using a
digital pH meter at room temperature.
The homogeneity of the herbal preparation was observed by visual appearance and by touch.
The term spreadability is expressed as the extent of the area to which the topical application spreads when applied to the affected region of the skin. The therapeutic efficacy of the herbal formulation is also dependent on its spreading range. Thus, it is necessary to determine the spreading ability of the prepared formulation. For the determination about 3 gms of cream was applied between the two glass slides and pressed to obtain a thin film of uniform thickness. A weight of 1000 gm was placed over the top slide to apply the required pressure for 5 minutes. Followed by addition of about 10 gms of weight in a pan and the upper slide was subjected to pull with the help of a string attached to a hook. The time taken by the two slides to slip over each other by a distance of 10 cm under certain load was noted. Following is the formula to calculate the spreadability of the prepared formulation.
S = m × L/T
Where,
S – Spreadability
m – Weight tied to upper glass slide
L –Length moved on a glass slide
T – Time taken
It was observed that formulated and marketed creams were easily washable under tap water.
The spreadability of formulated and marketed creams was tested, and it was observed that formulated cream has the same spreadability as marketed cream.
The physical stability of the formulations was studied by placing them in a plastic or a glass container and they were placed in a humidity chamber at 45°C. Their appearance and physical stability were inspected for a period of 24 hours.
RESULT AND DISCUTION
The current work was completed on the formulation and assessment of the herbal cream. A number of factors are taken into consideration when evaluating cream, including its colour, consistency, pH, Spreadability, viscosity, stability, washability, and skin irritancy test results.
Result of batch-2 Formulation:
Table 02: Evaluation Parameter
Results interpretation on hands:
Fig.no.08: before application of cream
Fig.no.09: after application of cream
The goal of the current study was to produce a turmeric herbal cream. There was good spreadability in the produced mixture. The cream had an excellent PH. During storage, cream does not exhibit any kind of pH separation. It was simple to remove once applied. The composition did not cause irritation or damage to the skin. Batch 2 of the formulation is thought to be the most stable.
CONCLUSION
The organoleptic properties of formulated herbal cream were evaluated, and the results were apt. Other physical parameters like pH, homogeneity, type of smear, emolliency, viscosity and type of emulsion were also evaluated accordingly and pH was found to be compatible with the pH of skin secretions and showed proper pH range that is approximately pH 6, prepared formulation showed good spread ability and emolliency. The thermal stability studies were also conducted for a month, there was no sign of separation of aqueous and oily phases. The formulated cream was studied for microbial contamination, no sign of microbial growth was visible after the specified incubation period of 24hrs.
ACKNOWLEDGMENT
I am grateful to the adviser and principal of SVS Institute of Pharmacy for providing the necessary resources. I also thank Dr. Atul N. Wagh of MSG College's Botany Department at Malegaon Camp, Nasik, for his assistance in identifying the plant material.
REFERENCE
Kalyani Khairnar*, Jitesh Desale, Mayur Gangurde, Formulation And Evaluation Of Herbal Cream Containing Curcumin From Curcuma Longa, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 6, 727-733. https://doi.org/10.5281/zenodo.11668928
10.5281/zenodo.11668928
