View Article

  • Formulation Design and characterization of Antifungal Emulgel for Topical Delivery

  • 1Department of Pharmaceutics, Vardhaman College of Pharmacy, Koli, Karanja (Lad), Washim-444105, Maharashtra, India
    2Department of Pharmaceutics, Priyadarshini J. L. College of Pharmacy, Electronic Zone Building, MIDC, Hingna Road, Nagpur-440016, Maharashtra, India
    3Department of Quality Assurance, Vardhaman College of Pharmacy, Koli, Karanja (Lad), Washim-444105, Maharashtra, India

Abstract

Emulgel is the latest generation in novel drug transport device used for manage launch of emulsion and gel for the reason of topical use. The steadiness of emulsion is increased, while it is integrated into gel. Miconazole is an antifungal drug has been used inside the remedy of dermatophytic infection. The aim of the existing look at was to formula design and characterization of antifungal emulgel to incorporate hydrophobic or poorly water-soluble drug in formulation and brought via gels and in an effort to increase skin penetration of drug. The gelling component Carbopol 934 is utilized in extraordinary attention in the system of Miconazole emulgel. Further, for oil phase instruction liquid paraffin as oil, span 20 as emulsifier is used and for aqueous section propylene glycol as co-surfactant, tween 20 as emulsifier, methyl paraben & propyl paraben as preservative is used. The pH of emulgel become adjusted to 6- 6.4 the use of triethanolamine (TEA). Miconazole acts by inhibiting the fungus from producing ergosterol, the fungal equivalent of LDL cholesterol, which will increase membrane fluidity and inhibits fungus increase. The organized emulgel were evaluated for his or her bodily appearance, pH determination, viscosity, spreadability. The in-vitro diffusion and drug content material research have been executed for all formulations. Physical characteristics of all the prepared emulgel have been desirable. When compared to all different formulations, the method batch F6 suggests higher drug release.

Keywords

Emulgel, Miconazole, Antifungal, Topical drug delivery

Reference

  1. Sah SK. Emulgel: Magnifying the application of topical drug delivery. Ind J Pharm Bio Res 2017;5(1):25-33. 
  2. https://en.m.wikipedia.org/wiki/Antifungal
  3. Raju k. Formulation and evaluation of Ornidazole topical emulgel. World J Pharm Pharma Sci 2019;8(7):1179-1197.
  4. Salunkhe P. Design and Characterisation of Emulgel of an Antifungal drug. Pharm. Sci. Res. 2019;11(6):2357-2361.
  5. Sharma DC. Design and characterization of apermilast loaded emulgel for topical treatment- a research. Int J Pharm Bio Sci. 2018, 8: 552- 562.
  6. Dr. Vallabhchandegra. Development of gel extraction process for aloevera leaves. Int J Res. 2012.
  7. Upadyaya S. Preparation and evaluation of miconazole nitrate transformal gel to enhance skin penetration & increase antifungal activity. World J Pharm Pharma Sci. 2020;9(12):1191-1208.
  8. Pawar AY. Formulation and evaluation of miconazole nitrate loaded nanoparticles for topical delivery. J Pharm Res Int. 2021;33(42B):102-123.
  9. Verma S. Formulation and evaluation of ketoconazole nanoemulgel– A research. World J Pharm Pharma Sci. 2016; 5(2):899-911. 
  10. Manna M. Development and formulation of aloe vera emulgel. GSC Bio Pharma Sci. 2020;12(02):161-166.
  11. Ali SS. Development and characterization of miconazole nitrate transformal gel. Int J Res Pharma Sci Tech. 2020;1(4):109-116.
  12. Bhise MR. Development of an aloe vera based emulgel for topical delivery of antifungal drug. Int J Bio Pharm Allied Sci. 2021;10(10):505-522.
  13. Mahajan SS. Formulation and evaluation of proniosomal topical antifungal gel of miconazole nitrate. Int J Pharma Sciences Drug Res.2021;13(2):128-139.
  14. Anju KP. Antifungal topical nanoemulgel containing miconazole nitrate. Int J Health Sci Res. 2021;11(11):208-227.
  15. Nagalakshmi S. Design development and evaluation of miconale nitrate topical gel for fungal infection. Int J Pharm Sci Res. 2015;6(3):1266-1272.

Photo
Pranali R. Gajbhiye
Corresponding author

Department of Pharmaceutics, Vardhaman College of Pharmacy, Koli, Karanja (Lad), Washim-444105, Maharashtra, India

Photo
Yogesh N. Gholse
Co-author

Department of Pharmaceutics, Priyadarshini J. L. College of Pharmacy, Electronic Zone Building, MIDC, Hingna Road, Nagpur-440016, Maharashtra, India

Photo
Rahul V. Jadhav
Co-author

Department of Quality Assurance, Vardhaman College of Pharmacy, Koli, Karanja (Lad), Washim-444105, Maharashtra, India

Photo
Nitin B. Kohale
Co-author

Department of Pharmaceutics, Vardhaman College of Pharmacy, Koli, Karanja (Lad), Washim-444105, Maharashtra, India

Pranali R. Gajbhiye*, Yogesh N. Gholse, Rahul V. Jadhav, Nitin B. Kohale, Formulation Design and characterization of Antifungal Emulgel for Topical Delivery, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 8, 118-128. https://doi.org/10.5281/zenodo.8249517

More related articles
A Comprehensive Review On Emulgel As A Topical Dru...
Niraj Gaikwad, Ritesh Aher, Mayuri Bagul, Yogesh Sharma, Dhanajay...
Solid Lipid Nanoparticles: A Novel Approach for Fu...
Shaikh Nasheer S., Joshi Maharudra R., Kazi Wasim B., Anantwal Ak...
A Formulation and Evaluation of Mefenamic Acid Emu...
Dajee Hulage , Dr. V. M. satpute, S. R. Ghodake, Someshwar More, ...
Nanogel In Modern Drug Delivery: A Comprehensive Review of Synthesis, Properties...
Dr. Shivappa Nagoba, Nivrutti Kotsulwar, Rachita Malshette, Maithili Kamble, Mayur Upade, Amrapali R...
Pharmacognostic Evaluation Of Crude Drugs ...
Rupali Bandgar, Gitanjali Deokar, Shital Darekar, Atish Patil, ...
Antifungal Activity from Papaya Seed ...
Shamir Tamboli, Amarsingh Shinde, Sourabh Chavare, Komal Salunkhe, ...
Related Articles
Nanogel In Modern Drug Delivery: A Comprehensive Review of Synthesis, Properties...
Dr. Shivappa Nagoba, Nivrutti Kotsulwar, Rachita Malshette, Maithili Kamble, Mayur Upade, Amrapali R...
A Review on Sesame (Sesamum indicum L.) ...
Pawar Nikita Nitin, Shendkar Akanksha Bharat, Kore Arundhati Narayan, Shelar Jagruti Jagannath, ...
Preparation And Evaluation Of Herbal Emulgel ...
Sakshi Labhade. , Kanchan Gursal, Bahaisti Patel, Rutuja shirode, Roshni sayyad, Tanuja kadam, Shubh...
Emulgels as Effective Carriers for Hydrophobic and Hydrophilic Drugs: A Review ...
Pratiksha Varhade, Pallavi Kandale, Vedangi Kulkarni, Shatrughna Nagrik, Dr. Shivshankar Mhaske, ...
A Comprehensive Review On Emulgel As A Topical Drug Delivery System...
Niraj Gaikwad, Ritesh Aher, Mayuri Bagul, Yogesh Sharma, Dhanajay Patil, Deepak Sonawane, ...
More related articles
A Comprehensive Review On Emulgel As A Topical Drug Delivery System...
Niraj Gaikwad, Ritesh Aher, Mayuri Bagul, Yogesh Sharma, Dhanajay Patil, Deepak Sonawane, ...
Solid Lipid Nanoparticles: A Novel Approach for Fungal Therapy...
Shaikh Nasheer S., Joshi Maharudra R., Kazi Wasim B., Anantwal Akshat B., Limaye Akhilesh S., Rajput...
A Formulation and Evaluation of Mefenamic Acid Emulgel Using Natural Permeation ...
Dajee Hulage , Dr. V. M. satpute, S. R. Ghodake, Someshwar More, ...
A Comprehensive Review On Emulgel As A Topical Drug Delivery System...
Niraj Gaikwad, Ritesh Aher, Mayuri Bagul, Yogesh Sharma, Dhanajay Patil, Deepak Sonawane, ...
Solid Lipid Nanoparticles: A Novel Approach for Fungal Therapy...
Shaikh Nasheer S., Joshi Maharudra R., Kazi Wasim B., Anantwal Akshat B., Limaye Akhilesh S., Rajput...
A Formulation and Evaluation of Mefenamic Acid Emulgel Using Natural Permeation ...
Dajee Hulage , Dr. V. M. satpute, S. R. Ghodake, Someshwar More, ...