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Abstract

Oral solid dosage forms are the preferred administration route for many drugs, especially for modified release products. However, for optimal therapeutic effect, the drug must be well absorbed throughout the gastrointestinal tract (GIT). Challenges arise when drugs have a narrow absorption window in the GIT or when they are unstable in GI fluids. Developing oral controlled release dosage forms becomes crucial not only to prolong drug delivery but also to enhance retention within the stomach or small intestine until complete drug release occurs. Gastro Retentive Drug Delivery Systems (GRDDS) offer a promising approach to address these challenges, particularly for drugs like Atorvastatin calcium, which undergo rapid clearance in the intestine. Successful formulation of a Gastro Retentive Drug Delivery System for Atorvastatin calcium was achieved using direct compression technique, employing different viscosity grades of Hydroxypropyl methylcellulose (HPMC) as binder, Avicel PH102 as diluent, sodium bicarbonate as a gas generating agent, talc as a glidant, and magnesium stearate as a lubricant. The optimized tablet formulation demonstrated 99.74% drug release over 24 hours, with sustained release characteristics and buoyancy throughout the study duration. Among the various HPMC grades tested, HPMC K100M exhibited the most significant retardation in drug release. The in vitro dissolution profile followed zero-order kinetics, indicating a controlled release mechanism.

Keywords

Atorvastatin Calcium, Dosage from, GRDDS

Reference

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Toushiba Javed Khan
Corresponding author

Central India College of Pharmacy Lonara, Nagpur

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Sheikh Samir Md. Mustafa
Co-author

Central India College of Pharmacy Lonara, Nagpur

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Asra S. Shaikh
Co-author

Central India College of Pharmacy Lonara, Nagpur

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Zoya F. Shaikh
Co-author

Central India College of Pharmacy Lonara, Nagpur

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Mohammad Jawwad
Co-author

Central India College of Pharmacy Lonara, Nagpur

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Amreen Tabassum
Co-author

Central India College of Pharmacy Lonara, Nagpur

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Tina K. Ramchandani
Co-author

Central India College of Pharmacy Lonara, Nagpur

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Prachi R. Kumbhalkar
Co-author

Central India College of Pharmacy Lonara, Nagpur

Toushiba J. Khan,Asra S. Shaikh, Zoya F. Shaikh, Mohammad Jawwad, Amreen Tabassum, Sheikh Samir Md. Mustafa, Ravi Kalsait, Tina K. Ramchandani, Formulation And Evaluation Of Gastroretentive Floating Tablet Of Atorvastatin Calcium As A Model Drug: A Review, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 323-329. https://doi.org/10.5281/zenodo.10653282

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