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  • Mechanochemically Synthesized Copper II and Silver I Complexes with Cefuroxime: A Promising Strategy to Combat Cephalosporin Resistant Bacteria
  • Department of Chemistry, The faculty of chemical and biological Sciences, The Islamia University Of Bahawalpur, Pakistan

Abstract

Pharmaceutical drug development frequently involves the use of complexation to modify the pharmacological, toxicological, and physico-chemical properties of drugs. In our investigation, we employed solvent-free (mechanochemical) synthesis techniques to create copper (II) and silver (I) complexes with cefuroxime. Various physico-chemical analyses, including infrared spectroscopy, UV/Visible spectroscopy, elemental analysis, melting point determination, solubility tests, and conductivity measurements, were utilized to characterize these complexes. Our findings led to the proposed chemical formulas of [Cu(CFU)2H2O] and [Ag(CFU)NO3], where CFU represents cefuroxime. To assess the antimicrobial activity of the synthesized complexes, we conducted experiments using the disc diffusion method against a range of bacteria, including Streptococcus pneumonia, Bacillus subtillus, Salmonella typhi, Klebsiella pneumoniae, Escherichia coli, Methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and Staphylococcus aureus. Our results demonstrated that these complexes exhibited superior antimicrobial activity compared to the free ligand. Analysis of the IR spectra indicated that cefuroxime coordinated with the metal ions through v(COO), v(C=O), and the oxygen atom of the water molecule. Moreover, distinct differences in the melting point, color, and electronic spectra of the complexes in comparison to the ligand strongly suggest the formation of coordination compounds.

Keywords

Drug Development, Complexation, Cefuroxime, Silver (I) complexes, Copper((II) complexes), Mechanochemical, Methicillin-resistant Staphylococcus aureus (MRSA)

Reference

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Maryam javaid
Corresponding author

Department of Chemistry, The faculty of chemical and biological Sciences, The Islamia University Of Bahawalpur, Pakistan

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Kainat Javeed
Co-author

Department of Chemistry, The faculty of chemical and biological Sciences, The Islamia University Of Bahawalpur, Pakistan

Maryam javaid, Kainat Javeed, Mechanochemically Synthesized Copper (II) and Silver (I) Complexes with Cefuroxime: A Promising Strategy to Combat Cephalosporin-Resistant Bacteria, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 127-134. https://doi.org/10.5281/zenodo.10077979

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