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Abstract

One of the most prevalent metabolic diseases that significantly raises the burden of disease on the world health system is diabetes mellitus. Diabetes mellitus (DM) is linked to several illnesses and medical disorders, including atherosclerosis, obesity, hypertension, and cardiovascular diseases. Type 1 diabetes, Type 2 diabetes, and gestational diabetes are the three main forms of diabetes mellitus. Many medication classes, including insulin, biguanides, sulfonylureas, metformin, DPP4 inhibitors, GLP-1 inhibitors, and SGLT2 inhibitors, are used to treat or manage diabetes mellitus. Included in this review are the types of diabetes mellitus, medications that treat the condition, and the sodium/glucose co-transporter [SGLT2] inhibitors. Large proteins called sodium/glucose co-transporters (SGLT) enhance the transport of sugars like fructose, galactose, and fructose while also transporting sodium. across a cell's plasma membrane from a range of tissues. The kidney's reabsorption of glucose is enhanced by SGLT receptors. Reduced reabsorption of glucose and increased excretion of glucose through the urine are the results of SGLT2 inhibitor inhibition. FDA-approved medications that are used to manage or control diabetes mellitus include canagliflozin, dapagliflozin, and empagliflozin.

Keywords

Diabetes Mellitus, Oral Antidiabetic Agents, Sodium Glucose Co Transporter Inhibitors 2 (SGLTI2)

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Photo
Atul Kshirasagar
Corresponding author

Department Of Pharmacy, LBYP College Of Pharmacy, Pathri, India

Photo
Ms. Priyanka Zendekar
Co-author

Department Of Pharmacy, LBYP College Of Pharmacy, Pathri, India

Photo
Dr. Gajanan Sanap
Co-author

Department Of Pharmacy, LBYP College Of Pharmacy, Pathri, India

Atul Kshirasagar*, Ms. Priyanka Zendekar, Dr. Gajanan Sanap, SGLT Inhibitors As Antidiabetic Agents, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 168-179. https://doi.org/10.5281/zenodo.10084378

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