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Abstract

Heart failure is a serious, progressive condition that occurs when the heart muscle Don,t pump enough blood .Annual number of death, s raised in India from 2.26 million to 4.77 million in between 1990 to2020 due to Cardiovascular diseases. Diuretics are an integral part of heart failure treatment, along with other medications to treat the underlying cause of heart failure. Diuretics help the kidneys flush out the excess fluid and maintain normal blood volume. The elimination of excess fluid reduces pressure in the veins and the overload of venous blood into the heart. The study is aimed to assess the efficacy and safety of diuretics in heart failure patients by improving the symptoms like SOB, palpitation e.t.c and observing any occurs side-effects occurs after the administered of Diuretics. A group of 100 patients who meet the inclusion criteria were taken. All the necessary and relevant data were collected from the patient casenotes, treatment charts,and laboratory reports .In these study we have categorized into before drug therapy and after drug therapy of same patient and observed the ejection fraction , symptomatic relief by using the NYHA scale and also observed the electrolytes imbalance in the blood .In these study , majority of patient were males with decreased cardiac function was observed The patient’s who are admitted with cardiac complication have shown positive response towards diuretic therapy as it shown major efficacy with minimum side effects.

Keywords

Heart failure, Cardiovascular diseases, Diuretics, Diuretic therapy, Symptomatic relief, Ejection fraction, NYHA scale

Reference

  1. Mann, Zipes, Libby,Bonow ‘BRAUNWALDS HEART DISEASE' – A Text Book of Cardiovascular Medicine, 10 TH Edition, Chapter 3 Page no- 613- 615,Chapter 38: 799-801.
  2. Vaterie C. Scanlon ,Tina Sanders Essentials of Anatomy And Physiology 5 TH Edition Page no– 219-317
  3.  HL Sharma And KK Sharma – Principles of pharmacology 5 TH Edition Section 4- Drugs affecting renal and cardiovascular system and related autocoid page no :- 230- 237
  4. BD Chaurasia Human Anatomy Regional and Applied Dissection and clinical volume 1 chapter 18 Page no: 239 - 255 
  5. Parts of the heart by Anatomy Next – THE HEART cited at : Anatomy .app
  6. Gavino Casu and Pierluigi Merella.Diuretic Therapy in heart failurecurrent approaches.2015 jul;10(1)42-47. 
  7. Rajaa F Faris, Marcus Flather ,Henry Purcell, Philip A poole Wilson,Andrew Js Coats.Diuretics for heart failure.2016 Apr.
  8. S Gupta et al. Diuretic usage in heart failure.2005 Apr,volume 26,Issue 7,2005
  9. MICHAEL M.BRAUN, DO.WILLIAM A.STEVENS, MD, AND CRAIG H. BARSTOW, MD, Stable coronary Artery disease, Stable Coronary Artery Discus: Treatment published March 15, 2018;97 (6) : 376 – 384
  10. 1Barry R. Davis, MD.Ph.D, Linda B.Piller, MD. MPH, Jeffary A. Cutler, MD, MPH, Curt Furberg, MD.PhD, Kay Dunn, Ph.D Stanley Franklin, MD, David Goff. MD., Ph.D Frans, Linen, MD, PhD, Syed Mohiuddin, MD Vasiliaspapadine triou, MD, Micheal Proschan, Ph.D Allan Ellsworth, Pharm D, John Golden, MD, Pedeo Colon, MD, Richard Crow, MD, Pedro Colon MD, Richard Crow, MD and for the Antihypertensive and Lipid Powering treatment to prevent Heart attack Trial (Allhat) Collaborative Research Group. Originally published 1 May 2006. circulation, 2006; 113:2201-2210.
  11. Centers for disease control and prevention. Coronary Artery Disease. Page last Reviewed; July 19, 2021.
  12. Emily Ford,Jon Adam,Nicholas Graves (2012).Development of an economic model to assess the cost effectiveness of hawthorn extract as an adjunct treatment for heart failure in Australia .BMJ open .2.10.1136/bmjopen-2012-001094.

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G. Anjani Tejaswi
Corresponding author

Department of Pharmacy practice, Hindu College of Pharmacy, Guntur-522002, Andhra Pradesh, India

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P. Shaheera
Co-author

Department of Pharmacy practice, Hindu College of Pharmacy, Guntur-522002, Andhra Pradesh, India

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A. Navya Sree
Co-author

Department of Pharmacy practice, Hindu College of Pharmacy, Guntur-522002, Andhra Pradesh, India

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M. Bala Tripura Sundari
Co-author

Department of Pharmacy practice, Hindu College of Pharmacy, Guntur-522002, Andhra Pradesh, India

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P. Seetaramayya
Co-author

Department of Cardiology, Srikrishna Institute Of Medical Sciences, Guntur, Andhra Pradesh, India

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Velaga Mahesh
Co-author

Department of Cardiology, Srikrishna Institute Of Medical Sciences, Guntur, Andhra Pradesh, India

G. Anjani Tejaswi, P. Shaheera, A. Navya Sree, M. Bala Tripura Sundari, P. Seetaramayya, Velaga Mahesh, Safety And Efficacy Of Diuretics With Reduced Ejection Fraction In Heart Failure Patients- An Observational Cohort Study, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 8, 215-222. https://doi.org/10.5281/zenodo.8280229

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