1,2,3,4Doctor of Pharmacy-Intern, Department of pharmacy practice, The Erode College of Pharmacy, Erode
Pyoderma is a prevalent dermatological condition encompassing a range of primary and secondary skin infections. Primary pyodermas, which include impetigo, folliculitis, furuncle, carbuncle etc., pose a significant burden in dermatological practice. Secondary pyodermas comprise conditions like infected pemphigus, infected contact dermatitis, and infected scabies, often compounding the clinical complexity. The most frequently isolated organism in pyoderma is Staphylococcus aureus, which can be methicillin-sensitive (MSSA) or methicillin-resistant (MRSA). MRSA is a concerning healthcare-associated pathogen, and many isolates exhibit multidrug resistance. The pathophysiology of skin infections primarily involves disruptions in the skin's barrier, enabling pathogenic microbes to enter and triggering systemic reactions. Secondary infections occur when these pathogens invade diseased skin, and the specific pathogenesis varies based on the primary condition. Diagnosing bacterial pyodermas primarily relies on visual examination, occasionally supplemented by culture tests to confirm the presence of the causative organism. Treatment objectives encompass halting the progression of infection, alleviating discomfort, managing recurrent furunculosis, ensuring cost-effective interventions with minimal adverse effects, and swiftly eradicating severe infections. Antibiotics play a pivotal role in achieving these goals, serving as the primary treatment choice. Topical agents like mupirocin and erythromycin are often employed to cleanse affected lesions, eliminating the source of infection and reducing the potential for spread. In cases of extensive or severe infection, systemic antibiotic therapy becomes essential, administered either orally or via injection, to ensure effective eradication of the pathogen. This highlights the importance of early diagnosis, appropriate antibiotic choice, and comprehensive management to prevent complications and reduce the disease burden, antimicrobial resistance.
Thayana Ramasamy*, Shavitha Jayaseelan, Gokulalakshmi Moorthy, Madhu Midha Muruganantham, The Skin Battle: Exploring The Depths Of Pyoderma Diagnosis, Treatment, And Management Strategies, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 10, 210-218. https://doi.org/10.5281/zenodo.10031276