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Abstract

Oral drug delivery is still the finest and most popular method for administering pharmaceuticals via the internal route. Sustained release is also a good option for reducing adverse effect of drugs and boosting its therapeutic potency. The fundamental ideas of sustained drug delivery system optimise a variety of factors, such as a drugs pharmaceutical, pharmacokinetic and pharmacodynamic properties in order to increase therapeutic efficacy, minimise side effects and make disease cure simple. The major goal of this review is to provide comprehensive information about sustained release dose and its benefits as well as to outline the numerous factors to consider when choosing a drug for a certain drug delivery system and techniques used in sustained release dosage forms. The review highlights the types of matrices, mechanisms involved, polymers used in matrix tablets, method of preparation and evaluation studies such as angle of repose, bulk density, tapped density, hausner’s ratio, carr’s index, hardness test, friability test, weight variation test, uniformity of thickness, disintegration test, in-vitro drug release, determination of drug content.

Keywords

Sustained release, Techniques, Matrix tablet, Polymers

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Muni Raja Lakshmi K
Corresponding author

Sri Venkateswara College of Pharmaceutical Sciences, S V University, Tirupati.

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Naseema Shaik
Co-author

Sri Venkateswara College of Pharmaceutical Sciences, S V University, Tirupati.

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Lavanya E
Co-author

Sri Venkateswara College of Pharmaceutical Sciences, S V University, Tirupati.

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Venkata Rao Gadde
Co-author

Sri Venkateswara College of Pharmaceutical Sciences, S V University, Tirupati.

Muni Raja Lakshmi K*, Naseema Shaik, Lavanya E, Venkata Rao Gadde, Formulation And Evaluation of Sustained Release Matrix Tablets – A Review, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 7, 170-181. https://doi.org/10.5281/zenodo.8114751

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