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  • Formulation and Development of Metformin Sustained Release Tablets by Hydrophilic Polymer
  • 1Student, Department of Industrial Pharmacy, Bharat Technology, Uluberia, Howrah
    2Associate professor, Department Of Industrial Pharmacy, Bharat Technology, Uluberia, Howrah

Abstract

Metformin HCL, the only biguanide still in use today, reduces peripheral insulin resistance and hepatic glucose production in people with Type 2 diabetes. It has a short plasma half-life and a low absolute bioavailability. The primary goal of this study was to create an oral sustained release metformin tablet employing the direct compression technique and rate-controlling ingredients like hydrophilic hydroxypropyl methylcellulose and Xanthan gum polymer. Thickness, weight fluctuation, hardness, consistency of drug content, and in vitro drug release were all assessed for all batches. The term "mean dissolution time," which describes the rate at which a medication is released from a dosage form, demonstrates a polymer's effectiveness in delaying drug release. When coupled with xanthan gum, the hydrophilic matrix of HPMC was able to successfully control metformin release for 12 hours. As a result, it is now possible to create sustained-release matrix tablets. According to data that fits the Korsmeyer equation, both erosion and diffusion could be exploited as drug release mechanisms.

Keywords

Metformin Hydrochloride, Diabetes Mellitus, Sustained Release, H.P.M.C k 100, Xanthan Gum, Korsmayer’s Equation

Reference

  1. A review of cellulose ethers in hydrophilic matrices of oral controlled release dosage forms. Alderman, D.A. 1984, Int.J.Pharm, pp. 1-9.
  2. Preparation and evaluation of a sustained release formulation of Nifedipine HPMC tablets, G.Yan, H.Li , R.Zhang , D. Ding. 2000, Drug Dev. Ind. Pharm, pp. 681-686.
  3. HPMC-matrices for controlled drug delivery: a new model combining diffusion, swelling, and dissolution mechanisms and predicting the release kinetics. J.Siepmann, H.Kranz , R.Bodmeier , N.A. Peppas. 1999, Pharm Res, pp. 1748-1756.
  4. Xanthan gum and alginate based controlled release theophylline formulations, M.F.Lu, L.Woodward , S.Borodkin,. 1991, Drug Dev Ind Pharm, pp. 1987-2004.
  5. Evaluation of xanthan gum as a hydrophillic matrix for controlled release dosage form preparations. M.M. Talukdar, J. Plaizier-Vercammen. 1993, Drug Dev Ind Pharm, pp. 1037-1046.
  6. 10-year followup of intensive glucose control in type 2 Diabetes. R.R.Holman, S.K.Paul, M.A.Bethel, D.R.Matthews,H.A Neil. 2008, N. Engl. J. Med, p. 1577?1589.
  7. Mechanism of sustained-action medication Theoretical analysis of rate of release of solid drugs dispersedin solid matrices. T.Higuchi. 1963, J Pharm Sci., pp. 1145 -1149.
  8. Novel use of similarity factors f2 and sd for the development of diltiazem HCl modifiedrelease tablets using a 32 factorial design. M.C.Gohel, M.K.Panchal. 2002, Drug Dev Ind pharm, pp. 77-87.
  9. H.A.Liberman, Lachman and J B Kanig. Theory and Practice of Industrial Pharmacy. [ed.] 3rd. 1990.
  10. H A LIberman, Lachman and J B kannig. Theory and practice of Industrial pharmacy. [ed.] 3rd Edition. 1990. pp. 293-345.
  11. Mithal, B M. A text book of Pharmaceutical formulations. [ed.] 12 edition. 2003. p. 101.
  12. Particle size analysis by sieve analysis. 2012 October. http://www.astm.org/standards/C136.htm.
  13. Liberman HA, Leon lachman,Schwartz JB. Pharmaceutical dosage forms. [ed.] 2nd Edition. New York : Marcel decker Inc, 1992. Vol. 3rd.
  14. G. S. Banker, L. R. Ander. The theory and practice of industrial pharmacy Mumbai. s.l. : Varghese Publishing House, 1987. pp. 293-345.
  15. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. D.M.Nathan, J.B.Buse , M.B.Davidson , E. Ferrannini ,R.R.Holman R.R, R. Sherwin. 2009, Diabetes Care, pp. 193-203.
  16. Mechanisms of solute release from porous hydrophilic polymers. R.W.Korsmeyer, R.Gurny, N.A.Peppas et al. 1983, Int J Pharm, pp. 25-35.
  17. Modeling and comparison of dissolution profiles. P.Costa, J.M.S.Lobo. 2001, Eur J Pharm Sci, pp. 123-133.

Photo
Subhajit Roy
Corresponding author

Student, Department of Industrial Pharmacy, Bharat Technology, Uluberia, Howrah

Photo
Mayukh Jana
Co-author

Associate professor, Department Of Industrial Pharmacy, Bharat Technology, Uluberia, Howrah

Photo
Amlan Bishal
Co-author

Associate professor, Department Of Industrial Pharmacy, Bharat Technology, Uluberia, Howrah

Photo
Anwesha Adak
Co-author

Student, Department of Industrial Pharmacy, Bharat Technology, Uluberia, Howrah

Subhajit Roy*, Mayukh Jana, Amlan Bishal, Anwesha Adak, Formulation and Development of Metformin Sustained Release Tablets by Hydrophilic Polymer, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 129-139. https://doi.org/10.5281/zenodo.8330636

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