1Student, Department of Industrial Pharmacy, Bharat Technology, Uluberia, Howrah
2Associate professor, Department Of Industrial Pharmacy, Bharat Technology, Uluberia, Howrah
Metformin HCL, the only biguanide still in use today, reduces peripheral insulin resistance and hepatic glucose production in people with Type 2 diabetes. It has a short plasma half-life and a low absolute bioavailability. The primary goal of this study was to create an oral sustained release metformin tablet employing the direct compression technique and rate-controlling ingredients like hydrophilic hydroxypropyl methylcellulose and Xanthan gum polymer. Thickness, weight fluctuation, hardness, consistency of drug content, and in vitro drug release were all assessed for all batches. The term "mean dissolution time," which describes the rate at which a medication is released from a dosage form, demonstrates a polymer's effectiveness in delaying drug release. When coupled with xanthan gum, the hydrophilic matrix of HPMC was able to successfully control metformin release for 12 hours. As a result, it is now possible to create sustained-release matrix tablets. According to data that fits the Korsmeyer equation, both erosion and diffusion could be exploited as drug release mechanisms.
Subhajit Roy*, Mayukh Jana, Amlan Bishal, Anwesha Adak, Formulation and Development of Metformin Sustained Release Tablets by Hydrophilic Polymer, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 129-139. https://doi.org/10.5281/zenodo.8330636