The objective of the present work was to formulate orally disintegrating tablets of sodium valproate and levetiracetam for rapid onset of action with an intention of increasing its therapeutic efficacy and also increase the compliance amongst geriatric, pediatric and uncooperative patients. The integrity of the drug sample was confirmed by physical characterization, melting point, solubility. Precompression blends of the ODTs were prepared and evaluated for its micromeritic properties. The angle of repose, bulk and tapped density, Hausner’s ratio and Carr’s Index were determined and all indicated that the prepared blends have excellent flow characteristics. Total four formulations of ODTs were prepared using direct compression method. The concentration of the super-disintegrant was varied depending on the method. Mannitol was used as the binder as well as sweetener while saccharin sodium was used as the additional taste masking agent in the formulations. All the formulations were subjected to post compression evaluation test and the results indicate that the formulation had hardness of 4 Kg/cm2, thickness of 8 mm, weight variation in the range of 2.7-4.6 %, friability of less than 1 %, drug content in the range of 97.80 to 98.60 %, wetting time from 21 to 49 seconds with water absorption ratio of more than 75 %, disintegration time of less than 30 seconds and a drug release of more than 90 % over a period of 5 minutes. The formulations were found to be stable under accelerated conditions for a period of 3 months with almost negligible change in the critical parameters.


Disintegration, Melting Point, Micromeritic, Precompression


  1. Dey P, Maiti S. Orodispersible tablets: a new trend in drug delivery. Journal of Natural Science, Biology and Medicine. 2010; 1(1): 2-5
  2. Chein YW. Oral drug delivery and delivery systems. 2nd ed. New York: Marcel Dekker; 1992.
  3. Mccarty, John A. Fast dissolving buccal tablet. United States Patent, US 5073374, 1991
  4. Nagai T, Machida Y, Suzuki Y, Ikura H. Method and preparation for administration to the mucosa of the oral or nasal cavity. United States Patent, US 4226848, 1980
  5. Suzuki Y, Ikura H, Yamashita G. Slow-releasing medical preparation to be administered by adhering to a wet mucous surface. United States Patent, US 4292299, 1981
  6. Kigasawa K, Shimizu H, Hayashi T, Watabe K, Tanizaki A, Koyama O, Wakisaka K, Ogawa Y. Soft buccal. United States Patent, US 4572832, 1986
  7. Hsiao CH, Cacace JL. Buccal formulation. United States Patent, US 4755386, 1988
  8. FDA guidance for industry. Orally disintegrating tablets. December 2008
  9. Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating tablets: Developments, technologies, taste-masking and clinical studies. Critical Reviews in Therapeutic Drug Carrier Systems. 2004; 21: 433–476.
  10. Dobetti L. Fast melting tablets: Developments & Technologies. Pharmaceutical Technology. 2001; 44-50.
  11. Subramanyam CVS. Text book of Physical Pharmaceutics, Vallabh Prakashan, 2nd ed., 2001.
  12. Abualhasan M, Odeh NW, Younis GN, Zeidan OF. Analytical Method Development for Sodium Valproate through Chemical Derivatization. International Journal of Analytical Chemistry. 2020; 5672183. Doi: 10.1155/2020/5672183
  13. Gawale K, Syed SM. Development and Validation of UV Spectroscopic and RP-HPLC Method for Determination of Levetiracetam in Bulk and Combined Dosage Form. Journal of Pharmaceutical and Applied Chemistry. 2021; 7(1): 25-32
  14. Aly AM, Semreen M, Qato MK. Superdisintegrants for solid dispersion to produce rapidly disintegrating tenoxicam tablets via camphor sublimation. Pharmaceutical Technology. 2005; 29(1): 68-78.
  15. Jain CP, Naruka PS. Formulation and evaluation of fast dissolving tablets of valsartan. International Journal of Pharmacy and Pharmaceutical Sciences. 2009; 1(1): 219-226
  16. Prameela AR, Archana N, Siva PT, Mohan PV, Sudheer MK, Bala CK. Formulation and evaluation of orodispersible metformin tablets. International Journal of Applied Pharmacy. 2010; 2(3): 15-21.
  17. Narmada GY, Mohini K, Prakash RB, Gowrinath DXP, Kumar KS. Formulation evaluation and optimization of fast dissolving tablets containing amlodipine besylate by sublimation method. ARS Pharmaceutica 2009; 50(3): 129-144.

Monika Sahu
Corresponding author

Lakshmi Narain College of Pharmacy, Raisen Road, Bhopal, Madhya Pradesh, India.

Dr. Kaushelendra Mishra

Lakshmi Narain College of Pharmacy, Raisen Road, Bhopal, Madhya Pradesh, India.

Dr. Parul Mehta

Lakshmi Narain College of Pharmacy, Raisen Road, Bhopal, Madhya Pradesh, India.

Monika Sahu*, Dr. Kaushelendra Mishra, Dr. Parul Mehta, Formulation and Evaluation of Orally Dissolving Tablets of Sodium Valproate and Levetiracetam, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 336-345.

More related articles
Formulation And In vitro Evaluation Of Bilayer Tab...
Mayur Aware, Sheetal Gondkar, Rishikesh Bachhav, ...
Development And Validation Of UV HPLC Method For T...
Amol Amrutkar, Smita Aher, Rishikesh Bachhav, ...
Formulation Development and Evaluation Of Wax Inco...
Amol Ghare, Sheetal Gondkar, Rishikesh Bachhav, ...
A Comprehensive Review On Analytical Method Development And Validation...
Amol Amrutkar, Smita Aher, Rishikesh Bachhav, ...
Method Development and Validation of Indacaterol Maleate By RP HPLC In Bulk and ...
Manali Katkade, Anagha Baviskar, Kiran Kotade, Charushila Bhangale, ...
Related Articles
Ayurvedic Remedies of Bacterial Meningitis...
Komal Ushir, Dinesh Rishipathak, Pragati Bhosale, Manisha Raut, ...