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Abstract

The objective of the present work was to formulate orally disintegrating tablets of sodium valproate and levetiracetam for rapid onset of action with an intention of increasing its therapeutic efficacy and also increase the compliance amongst geriatric, pediatric and uncooperative patients. The integrity of the drug sample was confirmed by physical characterization, melting point, solubility. Precompression blends of the ODTs were prepared and evaluated for its micromeritic properties. The angle of repose, bulk and tapped density, Hausner’s ratio and Carr’s Index were determined and all indicated that the prepared blends have excellent flow characteristics. Total four formulations of ODTs were prepared using direct compression method. The concentration of the super-disintegrant was varied depending on the method. Mannitol was used as the binder as well as sweetener while saccharin sodium was used as the additional taste masking agent in the formulations. All the formulations were subjected to post compression evaluation test and the results indicate that the formulation had hardness of 4 Kg/cm2, thickness of 8 mm, weight variation in the range of 2.7-4.6 %, friability of less than 1 %, drug content in the range of 97.80 to 98.60 %, wetting time from 21 to 49 seconds with water absorption ratio of more than 75 %, disintegration time of less than 30 seconds and a drug release of more than 90 % over a period of 5 minutes. The formulations were found to be stable under accelerated conditions for a period of 3 months with almost negligible change in the critical parameters.

Keywords

Disintegration, Melting Point, Micromeritic, Precompression

Reference

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Monika Sahu
Corresponding author

Lakshmi Narain College of Pharmacy, Raisen Road, Bhopal, Madhya Pradesh, India.

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Dr. Kaushelendra Mishra
Co-author

Lakshmi Narain College of Pharmacy, Raisen Road, Bhopal, Madhya Pradesh, India.

Photo
Dr. Parul Mehta
Co-author

Lakshmi Narain College of Pharmacy, Raisen Road, Bhopal, Madhya Pradesh, India.

Monika Sahu*, Dr. Kaushelendra Mishra, Dr. Parul Mehta, Formulation and Evaluation of Orally Dissolving Tablets of Sodium Valproate and Levetiracetam, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 336-345. https://doi.org/10.5281/zenodo.10143958

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