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  • Formulation and Evaluation of Sustained Release Tablet of an AntiDiabetic Drug Vildagliptin Using Natural Polymer
  • 1Department of Pharmaceutics, JIUU’s Ali – Allana College of Pharmacy and Research Center, Akkalkuwa, District – Nandurbar, Maharashtra – 425415, INDIA.  
    2,3,4,5Department of Pharmaceutics, JIUU’s Ali – Allana College of Pharmacy and Research Center, Akkalkuwa, District – Nandurbar, Maharashtra – 425415, INDIA.
    6,7Department of Pharmaceutics, JIUU’s Ali – Allana College of Pharmacy and Research Center, Akkalkuwa, District – Nandurbar, Maharashtra – 425415, INDIA.
    8JIUU’s Ali – Allana College of Pharmacy and Research Center, Akkalkuwa, District – Nandurbar, Maharashtra – 425415, INDIA

Abstract

The goal of the current study was to formulate and evaluate vildagliptin sustained release tablets. It is thought to be a good medicine for the development of sustained release tablets because of its short biological half-life (1.5 h), which will allow it to continue to have a therapeutic effect for longer. Vildagliptin is a novel dipeptidyl peptidase-4 inhibitor family of oral antihyperglycemic medication. Materials and Method: Sustain Release tablets were developed using a direct compression Method using various ratios of natural polymers (Gum). The preparations were examined for their compressibility index, Hausner's ratio, bulk density, and tapped density. statistical analysis The Fourier-transform infrared spectra of vildagliptin and Vildagliptin + polymers mixture, both separately and in combination, demonstrate the drug's compatibility with excipients. Results: The tablets physicochemical characteristics were confirmed to be within acceptable limits. The weight variation, thickness, hardness, friability, drug content, and in vitro release of the produced tablets were all evaluated. In vitro - dissolution studies were carried out using USP paddle apparatus ?, at 370C ± 0.50C in 0.1 N HCL (1.2 pH) for 12 hours. the optimized formulation F - 6 Shows the Maximum drug release 99.70 ± 0.5 in 12 hours of dissolution.

Keywords

Vildagliptin, Natural Gum, Neem Gum, Cassia Tora, Guggul Gum etc.

Reference

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Mayur Gokul Jayswal
Corresponding author

Department of Pharmaceutics, JIUU’s Ali – Allana College of Pharmacy and Research Center, Akkalkuwa, District – Nandurbar, Maharashtra – 425415, INDIA.

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Vasudev Sharma
Co-author

Department of Pharmaceutics, JIUU’s Ali – Allana College of Pharmacy and Research Center, Akkalkuwa, District – Nandurbar, Maharashtra – 425415, INDIA.

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Adnan Siddiqui
Co-author

Department of Pharmaceutics, JIUU’s Ali – Allana College of Pharmacy and Research Center, Akkalkuwa, District – Nandurbar, Maharashtra – 425415, INDIA.

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Raza Khan
Co-author

Department of Pharmaceutics, JIUU’s Ali – Allana College of Pharmacy and Research Center, Akkalkuwa, District – Nandurbar, Maharashtra – 425415, INDIA.

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Shaikh Aaqueeb Ahmed
Co-author

Department of Pharmaceutics, JIUU’s Ali – Allana College of Pharmacy and Research Center, Akkalkuwa, District – Nandurbar, Maharashtra – 425415, INDIA.

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Afsar Shaikh
Co-author

Department of Pharmaceutics, JIUU’s Ali – Allana College of Pharmacy and Research Center, Akkalkuwa, District – Nandurbar, Maharashtra – 425415, INDIA.

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Qazi Majaz Ahamad Aejazuddin
Co-author

Department of Pharmaceutics, JIUU’s Ali – Allana College of Pharmacy and Research Center, Akkalkuwa, District – Nandurbar, Maharashtra – 425415, INDIA.

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G. J. Khan
Co-author

JIUU’s Ali – Allana College of Pharmacy and Research Center, Akkalkuwa, District – Nandurbar, Maharashtra – 425415, INDIA.

Mayur Gokul Jayswal*, Vasudev Sharma, Adnan Siddiqui, Raza Khan, Shaikh Aaqueeb Ahmed, Afsar Shaikh, Qazi Majaz Ahamad Aejazuddin, G. J. Khan, Formulation and Evaluation of Sustained Release Tablet of an Anti-Diabetic Drug Vildagliptin Using Natural Polymer, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 457-468. https://doi.org/10.5281/zenodo.8394231

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