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Department of Pharmaceutical Quality Assurance, Mahatma Gandhi Vidyamandir's Pharmacy College Of Nashik - 422003
Due to low water-solubility, which makes their formulation challenging or even impossible, over 40% of the novel chemical entities (NCEs) identified by pharmaceutical industry screening programmes have historically failed to be commercialised. Several existing pharmaceuticals' distribution is hampered by the solubility problems that complicate the delivery of these new medications. In this article, numerous conventional and cutting-edge strategies for improving the solubility of BCS Class II medicines are briefly described. Co-solvents, Hydrotropy, Micronization, Alteration of Solvent's Dielectric Constant, Amorphous Forms, Chemical Modification of Drug, Surfactant Use, Inclusion Complex, Solvent's pH Alteration, Use of Hydrates or Solvates, Use of Soluble Prodrugs, Application of Ultrasonic Waves, Functional Polymer Technology, Controlled Precipitation Technology, Evaporative Precipitation in Aqueous Solute. Size reduction technologies, lipid-based delivery systems, micellar technologies, and porous microparticle technology are new drug delivery methods created in recent years to improve the solubility of insoluble pharmaceuticals. Also, a brief explanation of solid dispersion technique and several solid dispersion systems has been provided
Renuka Sagane*, Kiran Erande, Review On Methods Of Solubility Enhancement Of BCS Class II Drugs, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 64-76. https://doi.org/10.5281/zenodo.10463029
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10.5281/zenodo.10463029
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