Department of pharmacognosy Dr. Kolpe institute of pharmacy, kolpewadi, Ahilyanagar, Maharashtra-423602
Gulvel syrup Guvel syrup is also known as immunity-boosting syrup. Gulvel syrup is a concoction of sugar, honey, and occasionally alcohol. The syrup was created by combining gulvel powder, tulsi, turmeric powder, and ginger cloves. The parameters used to evaluate cough syrup are density, color, odor, viscosity, stability, and pH. Cough syrups come in two varieties: wet cough and dry cough. Asthma, hypertension, fever, malaria, fungal, bacterial, and cardiac disorders are among the acute and chronic conditions that are treated using various plant components that contain biologically active ingredients, such as the roots, bark, stem, and leaves.
In addition to suppressing the cough, cough drugs can help to ease the discomfort that comes with frequent coughing.
Cough Types:
Classifying coughs as either dry or wet is the most straightforward method of understanding them. While a dry cough does not create mucus or mucous, a wet cough does. The ease of administration of liquid medications to patients who have trouble swallowing solid dosage forms has generally been used as justification for their oral administration. Gulvel syrup: Another name for gulvel syrup is immunity booster syrup. Guvel syrup is defined as a mixture of sugar, honey, and sometimes alcohol. A mixture of gulvel powder, tulsi, turmeric powder, ginger, cloves, acacia nilotica, amla, clitoria ternatea flower, and prickly chaff was decocted to create the syrup.Gulvel is an effective immune modulator and aids in building a strong immune system. Giloy makes it easier to get rid of coughs brought on by pollen, smoke, or pollution allergies. It can also be used to treat tonsillitis. The phytochemical composition, antibacterial properties, and hemolytic activity of Achyranthes aspera (Amaranthaceae) leaves were examined. Asthma, fever, hypertension, malaria, fungal infections, bacterial infections, and heart disorders are among the acute and chronic conditions that are treated using various plant components that contain biologically active chemicals, such as the root, bark, stem, and leaf.
Advantages of Gulvel cough syrup:
? No side effects.
? No harmless.
? Easily available.
? Patient can be self administred.
? Easy to adjust the dose for patient’s weight.
? It can redused coughing and help you sleep better.
? It can boost immune system and help the body fight infection.
? It is natural and safe medication.
? It is also the most effective herb for cough and cold.
? Strong patient adherence, particularly for younger patients because the syrup testes good during testing
? As osmotic pressure, it acts as a preservative by preventing the growth of bacteria.
Disadventages of gulvel cough syrup:
? Microbial contamination take place if preservatives are not added in accurate proportion.
? Flucution in storage temperature may cause crystallization of sucrose from saturated syrup.
? Another disadvantage is the risk of self dosing ofsyrup which is very rare.
MATERIAL AND METHOD
Following parts are used in the formulation of syrup for treatment of cough.
|
Sr. no |
Ingredients |
|
1 |
Gulvel powder |
|
2 |
Amla |
|
3 |
Prickly chaff |
|
4 |
Acacia nilotica |
|
5 |
Clitoria ternatea flower |
|
6 |
Honey |
|
7 |
Turmeric powder |
|
8 |
Tulsi |
|
9 |
Ginger |
|
10 |
Clove |
FOLLOWING ARE THE INGREDIENTS USED IN FORMULATION:-
1.GULVEL PLANT
Scientific name: Tinospora cordifolia.
Family: Menispermaceae.
Biological source:It is a pretty widespread shrub that grows over small trees and hedges in dry and deciduous woodlands. From Kumaon to Assam, the plant can be found in the tropical region of India up to 1,200 meters above sea level. In the north, it can be found extending across West Bengal, Bihar, Deccan,Konkan, Karnataka & Kerala.
Benefits Of Gulvel Syrup:
2.Emblica officinalis gaertn( Amla ):
Biological name: phyllanthus emblica L., Amla/gooseberry
Family: Euphorbiaceous
Biological source:The pericarp of the plant Emmica officinalis Gaerth Phyllanthus emblica Linn. is always full of both fresh and dried fruits.
3.Prickly chaff :
Scientific name : Achyranthes aspera L.
Family: Amaranthaceae
Biological source :
4.Acacia nilotica :
Scientific name : Acacia auriculiformis A.cunn.ex Benth
Family : Leguminosae
Biological source : The dried, gooey substance known as acacia is extracted from the stems and branches of the acacia senegal plant.
Benefits :
5.clitoria Ternatea flower:
Biological name : butterfly
Family : Fabaceae
Biological source : sources of natural foods,colours and antioxidants
Uses : ntipyretic anti-microbial, anti-pyretic, antiinflammatory, analgesic
6.Honey :
Scientific name : apis(genus)
Family : Apidae
Biological source : The honeybee Apis mellifera produces honey naturally from the nectar of flowers.
Chemical constituents : Traces of the B vitamins folic acid, niacin, and riboflavin can be found in honey.
Uses : Turmeric (Curcuma longa) has many pharmacological and therapeutic uses in addition to being used as a spice, preservative, and coloring agent.
8.Tulsi
Scientific name:Ocimum tenuiflorum
Family: Lamiaceae
Biological source:Tulsi is a natural plant that is thought to have originated in north central India.
Uses: respiratory disorders, asthma, cough, and colds.
9. Ginger :
Scientific name : Zingiber officinale (Ginger).
Family : Zingiberaceae
Biological source: The rhizome, or underground stems, of the zingiber officinale plant are the source of ginger.
Uses : used to treat cardiac conditions, diarrhea, and colds.
10. Clove :
Biological name : Syzygium aromaticum
Family : myrtaceae
Biological source : The dried flower buds of the Syzyjium aromaticum tree are used to make cloves.
Uses : allergy, asthma, and inflammatory disease.
Excipients Profile :
|
Sr.no |
Excipients |
Uses |
|
1 |
Propylene glycol |
Drugs stabilizers,food additive |
|
2 |
Methyl paraben |
Preservative |
|
3 |
Papermint oil |
Flavouring agents |
|
4 |
Amaranth solution |
Colouring agent |
|
5 |
Honey |
Sweating agent , thickening agent |
|
6 |
Purified water |
Vehicle |
Preparation of extraction:
1) To make extract, mix 200ml of water with 20g of gulvel stem powder on average, and then heat the mixture gradually. After filtering, the extract was allowed to cool.
2) To prepare the extract, combine 5 grams of powdered turmeric with 100 milliliters of water and heat it gradually. After filtering, the extract was allowed to cool.
3) Combine 100ml of water and 10g of tulsi leaves, then gradually heat to create the extract. After filtering, the extract was allowed to cool.
4) Combine 100ml of water and 10g of ginger, then gradually heat to create the extract. After filtering, the extract was allowed to cool.
5) Combine 100ml of water and 10g of cloves, then gradually heat to create the extract. After filtering, the extract was allowed to cool.
6) The filtrate was used to make the finished syrup.
Harvesting of Clitoria Ternatea fresh flowers
↓
Washing of fresh flowers
↓
Shade drying at home
↓
Grinding the dried flowers
↓
Collect the powder
↓
Powder add in 94% methanol
↓
Allow to 5 days
↓
Filter and collect the extraction
↓
Collection of fresh Alma
↓
Washing and drying
↓
Grinding
↓
Collect the powder
↓
During five days, the powder dissolves in 94% methanol.
↓
Collection and filtering of extraction
Process :
1) To make the final syrup, add 20 milliliters of gulvel, 25 milliliters of honey, 4 milliliters of amla, 4 milliliters of prinkly chaff, 4 milliliters of acacia nilotica, 4 milliliters of clitoria ternatea flower, 4 milliliters of turmeric extract, 5 milliliters of tulsi, 4 milliliters of ginger, and 4 milliliters of clove. Slowly, while continuously staring, add the preservative.
2) After combining all of the extracts, 100 milliliters of syrup were produced.
3) After the finished syrup was made, it was evaluated.
4) After making the syrup, the solubility was assessed by visually analyzing the solution's clarity.
5) Once the syrup is ready, pour it into an amber bottle, label it neatly, and store it somewhere cool.
Evaluation Parameters:
Evaluation of cough syrup :
Colour:
The syrup has a yellowish brown color.
Odour:
The scent of syrup is aromatic.
PH:
Determination pH: used a pH paper to measure the final syrup's pH range and put a precisely measured amount in a beaker.
Viscosity:
The Ostaward viscometer was used to measure the viscosity.
Density:
The particular The density of distilled water at room temperature is o.997gm/ml, while the syrup's gravity is 1.0334. Syrup density = specific 1.0334×0.997 = 1.0302998 is the ratio of the density of distilled water to the gravity of syrup.
Specific Gravity :
The specific gravity bottle is weighed when it is empty, then it is weighed again after water and syrup are added. W1gm is the weight of an empty specific gravity bottle. Weight of a bottle with specific gravity and water (w2gm) Weight of a bottle with specific gravity and syrup W3gm W2=84.04, W3=85.7, and W1=35.30 w3-w1÷w2-w1 = 50.41÷48.78 = 1.0334 is the specific gravity.
|
Sr no. |
Evaluation Parameters |
Interface |
|
|
Colour |
Reddish Brown |
|
|
Odour |
Aromatic |
|
|
Specific Gravity |
1.0334 |
|
|
Density |
1.0302998 |
|
|
Viscosity |
120 Sec |
|
|
pH |
5.6 |
RESULT AND DISCUSSION:
The herbal cough syrup's overall formulation is used to treat colds, coughs, respiratory disorders, asthma, and as an anti-inflammatory and anti-tussive. The current study aids in the development of cough syrup that uses honey as a foundation and is both safe and effective.
CONCLUSION:
A mix of substances intended to relieve cough symptoms is probably used in the creation of Gulvel cough syrup. Herbal extracts, expectorants, cough suppressants, and sometimes some flavorings or sweeteners for palatability are some examples of these substances. Additionally, the manufactured syrup's physichemical characteristics—such as color, taste, odor, pH, and viscosity—were satisfactory; yet, the formulation met all requirements, including having the right amount of honey according to IP and being a good preservative. The current study aids in the development of a cough base made of honey that is both safe and effective.
REFERENCES
Pallavi pandit*, Aditi Pacharane, Kanchan Pandit, NIKUM R. D., To Formulation and Evaluation of Herbal Cough Syrup, Int. J. of Pharm. Sci., 2025, Vol 3, Issue 5, 1234-1241. https://doi.org/10.5281/zenodo.15364981
10.5281/zenodo.15364981
