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1,2,3,4 Department of Pharmaceutics, Sarada Vilas College of Pharmacy Mysuru, Karnataka, India
5Department of Pharmacognosy, Sarada Vilas College of Pharmacy Mysuru, Karnataka, India
Excipients have a clearly defined functional purpose and are no longer regarded as inert constituents in formulations. The need for high-speed manufacturing and direct compression in tableting has compelled the excipient industry to look for new excipients. Excipients are crucial for creating a dosage form. A co-processed excipient is a mixture of two or more compendial and non-compendial excipients that have been specially formulated to alter its physical characteristics in a way that cannot be accomplished by merely mixing them physically and without causing a substantial chemical shift. These excipients' have better flow ability, compressibility, tablet manufacturing. These are prepared by spray drying, solvent evaporation, spherization, melt extrusion, and granulation/agglomeration method. Products like Dipac, Ludi flash, Prosolv, and others have already shown their value in the market by lowering the price and quantity of ingredients while keeping the efficacy of the formulation. Such excipients face some limitations due to their quality assessment and reproducibility of results. This review includes a explanation on the benefits, preparation techniques, use of high-end technologies, and a compilation of research on co-processed excipients in the literature.
Prajwal K. , Parthasarathi K. Kulkarni, Nagendra R. , Venkatesh K. , Hanumanthachar Joshi, Co-Processed Excipients: A Review, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 154-163. https://doi.org/10.5281/zenodo.10628391
10.5281/zenodo.10628391