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Abstract

Present research work attempts to design, formulate and optimize the floating pulsatile drug delivery system (FPPDS) intended to treat nocturnal hypertension. FPPDS was designed based on central reservoir system containing effervescent agent with rupturable coating and a buoyant layer on top of the coated core. This system consists of rapid release core that contains drug with disintegrants, osmogent (sodium chloride) and effervescent agent (sodium bicarbonate and tartaric acid) which was film coated by hydrophobic polymer Ethyl Cellulose(EC) with polyethylene Glycol(PEG) 6000 as a plasticizer for controlling membrane permeability to provide pulsatile drug release with the target lag time of 6 hours. This pulsatile release tablet was further press coated from one side with Sodium bicarbonate, HPMCK100 and Carbopol to produce buoyant layer for the high floating duration time and less floating lag time. Atenolol being absorbed in upper GI tract and used to treat chronological cardiovascular disease was used as a model drug. Total of 39 formulations were formulated and dissolution test were performed using USP type II at 50 RPM for 8 hours in 0.1N HCl. Results revealed that both coating composition were significant factors in affecting pulsatile lag time and cumulative percentage drug release. Similarly, HPMCK100 and sodium bicarbonate showed the significant role for determining floating lag time.

Keywords

Pulsatile drug delivery system, Atenolol, floating, coating, effervescent

Reference

  1. Balpande, H. M., Raut, N. S., Umekar, M. J., & Kotagale, N. R. (2013). Compatibility study of metformin with pharmaceutical excipients. Int. J. Chem. Tech. Res, 5(1684), e1693. 
  2. Chidambaram, M., & Krishnasamy, K. (2014). Drug-drug/drug-excipient compatibility studies on curcumin using non-thermal methods. Advanced pharmaceutical bulletin, 4(3), 309. 
  3. ICH guidelines for Analytical Method Validation.  www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q2_R1/Step4/Q2_R1__Guideline.pdf
  4. Kalsbeek, A., Palm, I., La Fleur, S., Scheer, F., Perreau-Lenz, S., Ruiter, M., . . . Buijs, R. (2006). SCN outputs and the hypothalamic balance of life. Journal of biological rhythms, 21(6), 458-469. 
  5. Krögel, I., & Bodmeier, R. (1999). Floating or pulsatile drug delivery systems based on coated effervescent cores. International journal of Pharmaceutics, 187(2), 175-184. 
  6. PandeySharmila. (2010). In vitro characterisation of Pulsatile drug delivery system containing Atenolol.   
  7. Rowe, R. C., & Sheskey, P. J. (2009). Marian E Quinn Handbook of Pharmaceutical Excipients: Pharmaceutical press.
  8. Sharma, N., Agarwal, D., Gupta, M., & Khinchi, M. (2011). A comprehensive review on floating drug delivery system. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2(2), 428-441. 
  9. Sharma, p. K. (2010). Formulation and release characteristics of novel monolithic hydroxyl propyl methyl cellulose matrix tablets containing metronidazole deepak kumar mourya, rishabha malviya, mayank bansal. 
  10. Shidhaye, S., Lotlikar, V., Ghule, A., Phutane, P., & Kadam, V. (2010). Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases. Systematic Reviews in Pharmacy, 1(1). 
  11. Sungthongjeen, S., Sriamornsak, P., & Puttipipatkhachorn, S. (2008). Design and evaluation of floating multi-layer coated tablets based on gas formation. European Journal of Pharmaceutics and Biopharmaceutics, 69(1), 255-263.

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Sajan Maharjan
Corresponding author

Department of Pharmacy, CiST College, New Baneshwor, Kathmandu

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Bhaskar Shrestha
Co-author

Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre

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Himal Chhetry
Co-author

Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre

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Panna Thapa
Co-author

Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre

Bhaskar Shrestha, Sajan Maharjan*, Himal Chhetry, Panna Thapa, Formulation and in vitro evaluation of floating pulsatile drug delivery system of Atenolol based on coated effervescent core, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 8, 140-151. https://doi.org/10.5281/zenodo.8249869

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