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Abstract

Recently, there has been a rise in interest in the emerging topic of porous coordination polymers and metal organic frameworks. The storage and separation of gases, sensors, catalysis, and functional materials are just a few of the applications that these microporous materials have discovered in the last ten years. Better coordination of organic frameworks with porous metals is needed. Polymers with particular functions. Gaining a thorough knowledge of the connection between is a crucial topic. Employing contemporary theoretical methods, one can determine molecule characteristics and structures, preferred adsorption sites, and attributes. It is essential and crucial to develop a regulated drug delivery system in order to minimize adverse effects and improve the therapeutic effectiveness of medications. The scientific community has paid close attention to metal-organic frameworks (MOFs) and nanoscale MOFs (NMOFs), porous hybrids built by polydentate bridging ligands and metal-connecting nodes. Superior porosity, compositions and architectures, and simpler surface modification. Encapsulate small compounds in monodisperse zeolitic imid-azolate framework-8 (ZIF-8) nanospheres. The single-crystalline, homogeneous 70 nm ZIF-8 nanospheres with small-molecule encapsulation are identified by electron microscopy, powder X-ray diffraction, and elemental analysis. Several little compounds, including the anticancer medication camptothecin and fluorescein, were encapsulated inside the Framework for ZIF-8. ZIF-8 nanospheres with fluorescein are being evaluated in MCF-7 breast cancer cells. Cell line showed low cytotoxicity and internalisation of cells. MOF-based drug delivery systems (DDSs) with high drug loading capacity, strong physiological stability, and great biocompatibility and targeted, controlled medication release.

Keywords

MOF’s, ZIF-8, Targeted, MCF-7, Cancer, Nanospheres

Reference

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Photo
Sagar A Sarode
Corresponding author

KYDSCT’s College of Pharmacy, Sakegaon, Bhusawal, 425 201, Dist. Jalgaon, MS, India.

Photo
Yogesh N Sonawane
Co-author

KYDSCT’s College of Pharmacy, Sakegaon, Bhusawal, 425 201, Dist. Jalgaon, MS, India.

Photo
Mayuri A Sarode
Co-author

KYDSCT’s College of Pharmacy, Sakegaon, Bhusawal, 425 201, Dist. Jalgaon, MS, India.

Photo
Parag R Patil
Co-author

KYDSCT’s College of Pharmacy, Sakegaon, Bhusawal, 425 201, Dist. Jalgaon, MS, India.

Photo
Adityaraj D Kumbhar
Co-author

Shree Santkrupa Shikshan Sansthan Sansta’s College of Pharmacy, Ghogaon.

Photo
Vaishali A Patil
Co-author

Shree Santkrupa Shikshan Sansthan Sansta’s College of Pharmacy, Ghogaon.

Sagar A Sarode*, Yogesh N Sonawane, Mayuri A Sarode, Parag R Patil, Adityaraj D Kumbhar, Vaishali A Patil, Recent Progress In Metal Organic Framework As Drug Delivery Platform, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 10, 124-139. https://doi.org/10.5281/zenodo.10011967

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