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Abstract

An herbal tooth powder formulation was developed sometimes a blend of powdered botanicals like typically including clove, neem, turmeric, triphala are selected for antimicrobial, anti-inflammatory, they study the organoleptic properties and have safety of a newly formulated tooth gum powder. Safety test it is showed no adverse effects such as swelling and redness and also irritation. The formulation has evaluation tests, like pH, moisture content, organoleptic and stability test. Menthol is used for flavoring and concentration range if 0.1-0.5%, and it is providing cooling sensation. Also, Mannitol is sweetener cooling agent and 2-10% concentration, Improved mouth feel. This qualities of product are in good quality as a natural oral hygiene product .There is a long period of safety of gum. The organoleptic analysis that the powder possesses colour, odour, texture, taste.

Keywords

NUG, ANUG, Herbal tooth powder, Oral hygiene, antimicrobial activity, Physicochemical evaluation, Natural formulation.

Introduction

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The introduction  discusses the serious  role of oral hygiene in maintaining overall health, there is various dental problem like plaque formation, gingivitis, and periodontal diseases. Problems with commercial products are often contain synthetic ingredients that can cause adverse effects, such as irritation. There is increasing interest in developing herbal formulations that are safer, effective, and environmentally friendly product. It develops oral hygiene formulation by promoting healthy tooth gums and by using herbal ingredients it minimizes less side effects or no adverse effect. The herbal excipients are used in non-herbal excipients for less side effect also used for a long-term safety for oral tooth gum protected from  many diseases like gingivitis a mils gum inflammation , periodontitis (severe gum diseases), acute necrotizing ulcerative gingivitis.[1-4].

Herbal tooth powders and gums, prepared using natural ingredients, offer multiple therapeutic benefits such as antimicrobial, anti-inflammatory, antioxidant. Medicinal plants like Neem (Azadirachta indica), Clove (Syzygium aromaticum), Tulsi (Ocimum sanctum), and Triphala are well known for their traditional use in maintaining oral hygiene and preventing dental infections. This project focuses on the design and characterization of a herbal tooth gum powder formulated from selected medicinal plant ingredients. The formulation aims to combine the mechanical cleansing effects of powder with therapeutic benefits of herbal extracts to provide an effective, natural, and safe oral hygiene product. The study also involves evaluation and characterization of the prepared formulation based on parameters such as organoleptic properties, pH, moisture content, stability. The overall objective of this project is to develop a herbal-based oral hygiene formulation that promotes healthy gums and teeth while minimizing the side effects associated with synthetic oral care products. [3]

    1. Types of diseases :

Gingivitis : Mild gum inflammation and most common. [1]

Periodontitis : It is severe gum disease which have destructive of stage of gum .[3]

Necrotize Ulcerative Gingivitis [NUG] : The fast  bacterial  infection  by less  hygiene.[5]

  1. Gingivitis (Mild Gum Inflammation) :

Gingivitis is the most common and mildest form of gum disease. It can be reversed with proper treatment.

Cause : Accumulation of plaque and tartar (hardened plaque) at the gumline.

Location : Affects only gingival (the soft tissue surrounding the teeth.)

Symptoms : Gums become red, swollen, and bleed easily during brushing or flossing. Pain is typically minimal or absent.

  1. Periodontitis (severe gum diseases) :

Periodontitis  is the destructive stage of gum diseases, progressing from untreated gingivitis. It is irrepressible and requires professional intervention to manage.

Progression : The infection spreads below the gumline, causing the gums to pulls away from the tooth, forming pockets(periodontal pockets).

Damage : The body’s immune response, combined with bacterial toxins, starts to break down the bone and tissues that anchor the teeth.

Symptoms : Receding gums, persistent bad breath, visible spaces between teeth, loose teeth, and eventual  tooth loss.

  1. Acute Necrotizing Ulcerative Gingivitis (ANUG)

Often referred to as “Trench Mouth”, ANUG, is a severe, painful infection.

Cause : A rapid, aggressive bacterial infection often triggered by poor hygiene, stress, smoking, or a weakened immune system.

Symptoms : Severe, sudden pain, bleeding, and distinctive crater-like ulcers on the  gum covered by a grayish film.

Treatment : Professional dental cleaning, antibiotics, pain relief and improve oral hygiene help control the infection quickly.

  1. MATERIALS AND METHODS :-
    1. Materials :

The following herbal ingredients were selected based on their traditional use and  documented antimicrobial, anti-inflammatory and it is beneficial for oral hygiene.[1-4]

Herbal Ingredient

Botanical Name

Part Used

Therapeutic Role

Neem

Azadirachta indica

Leaves

Anti-bacterial, anti-inflammatory

Clove

Syzygium aromaticum

Buds

Analgesic antiseptic

Turmeric

Curcuma longa L

Rhizome

Antimicrobial, anti-oxidant, analgesic(Pain Relief)

Triphala

- (Amalaki, Haritaki)

Fruits

Antioxidant oral cleansing

All raw materials were procured from certified Ayurvedic raw drug suppliers and authenticated by a botanist.

  • List of chemical excipients:-

The following non-herbal excipients which help improves stability, texture, shelf life, and usability while keeping the product safe and effective[1,11,17]

Chemical Excipient

Purpose / Function

Typical Concentration Range (%W/W)

Remarks

Microcrystalline cellulose(MCC)

Diluent, filter, improves flow and bulk density

5-20%

Provides free-flowing characteristics and uniform blending with herbal powders; non-reactive.

Kaolin (Light)

 

Mild abrasive, adsorbent

5-15%

Gently cleans teeth without scratching enamel; helps absorb toxins and impurities from gums.

Sodium Bicarbonate (NaHCO3)

 

Mild abrasive, ph. adjuster, deodorizing agent

1-5%

Neutralizes acids in the mouth, reduces halitosis, and helps maintain an alkaline environment.

Menthol Powder

 

Flavoring, cooling, refreshing agent

0.1-0.5%

Provides a cooling sensation and fresh breath; enhances sensory acceptability.

Sorbitol

 

Sweetener, humectant, moisture, stabilizer

2-5%

Prevents dryness and improves taste; helps retain slight moisture to prevent caking.

Colloidal Silicon Dioxide (Aerosil)

 

Glidant, anti-caking, flow enhancer

0.1-1%

Improves powder flow and prevents clumping or moisture uptake.

Hydroxypropyl Methylcellulose (HPMC K4M or K100M)

Mucoadhesive polymer, binder, film-forming agent

0.5-2%

Provides adhesion to gums and teeth surfaces, improving contact time and therapeutic action of herbal actives.

Mannitol

 

Humectant, mild sweetener, cooling agent

2-10%

Improves mouth feel and taste; provides slight sweetness without promoting dental caries.

    1. Methodology :

The keywords we use is herbal tooth powder,  neem antimicrobial activity. Also, we used to google scholar for research paper we use many articles and  the references  for research of herbal and non-herbal excipients and their advantages for oral herbal tooth gum powder. Also used google website like plagiarism checker for plagiarism of review paper. The overall methodology supported by references, the product as high quality save and effective for oral hygiene and common  disease  like gingivitis and other oral tooth gum diseases.[13]

    1. Methods of preparation of tooth gum powder :
  1. Raw plant material was cleaned and shade-dried and grinded in fine particles.
  2. Powders were passed through #80 sieve to obtain uniform particle size. All the powders were mixed using geometric dilution to ensure uniform blending.
  3. Take the tiny amounts of chemical excipients to make exactly 20g of the herbal tooth gum powder.
  4. After taking all the excipients, chemical grind them together with the pestle until they are very fine.
  5. Now add active herbal excipients, keep mixing until the color is exactly the same through the whole bowl. Mix it very hard at least 10 to 15 minutes. And then sieve the mixed powder through mesh no.80.[1-4]
    1. Evaluation Test
  1. Organoleptic Evaluation :
  • Colour- Colour is uniform light green to brownish yellow.
  • Odor- It have refreshing clove and menthol scent.
  • Texture- Fine, smooth powder with no visible large particle.
  • Taste- It is slightly pungent (from clove) and refreshing.
  1. Physicochemical Tests
  • pH  Value- Mix 1g of powder in 10ml of distilled water and use digital pH meter. The result is come between 7.9, means it is neutral to slightly alkaline. It ensures that it is safe for tooth gum.
  1. CONCLUSION :-

Herbal tooth gum powder offers a natural and gentle approach to maintaining oral health. By combining plant-based ingredients known for their cleansing, antibacterial, and soothing properties, it can help support stronger gums, reduce plaque buildup, and promote fresher breath. Unlike many synthetic products, it typically avoids harsh chemicals, making it a suitable option for those seeking a more holistic dental care routine. However, consistent use, proper oral hygiene practices, and regular dental check-ups remain essential to achieve the best results.  Herbal tooth gum powder represents a traditional yet effective alternative for maintaining oral hygiene in a natural way. Its blend of herbs, minerals, and plant extracts works synergistically to clean teeth, strengthen gums, and combat harmful bacteria without relying on artificial additives. Regular use can contribute to improved gum health, reduced sensitivity, and a cleaner oral environment. Additionally, it aligns well with eco-friendly and sustainable lifestyles due to its minimal processing and biodegradable nature.

While herbal tooth powders provide multiple benefits, they should be used correctly and complemented with proper brushing techniques and routine dental visits. Overall, incorporating herbal tooth gum powder into daily oral care can be a safe, economical, and holistic choice for long-term dental wellness.

  1. RESULT & DISCUSSION:-

The development of this herbal tooth gum powder was aimed at creating a natural, effective, and nonabrasive alternative to synthetic oral care products. The formulation combines traditional Ayurvedic knowledge with modern pharmaceutical excipients to ensure stability, ease of use, and therapeutic efficacy.

The primary focus was on the synergistic effect of the four herbal components. Neem was incorporated as a potent antibacterial agent to combat plague-forming bacteria, while Clove provides essential analgesic properties, making the powder effective for individuals with minor gum sensitivity. Turmeric acts as a natural anti-inflammatory agent, which is crucial for reducing gingival swelling. The additional of Triphala serves as an anti-oxidant, helping to tone and strengthen the gum tissue.

Unlike traditional raw powder this formulation is used microcrystalline cellulose and kaolin as the base this provide a control abrasive action that cleans the teeth surface without causing the erosion of enamel, which is very common issue with coarser powders. The inclusion of HPMC K4M(hydroxypropyl methylcellulose) is a strategic choice ; as a mucoadhesive polymer, it helps herbal active stay in contact with the gum for a longer duration after application, thereby enhancing the therapeutic effect. 

The evaluation result is indicated that the powder maintains a pH of approximately 7.0 to 8.5 this is neutral to slightly alkaline range is an ideal for an oral cavity, as it helps neutralize the acidic environment created by food. The organoleptic properties are comed after the formulation like the color, odor test, texture, and taste.

  1. ACKNOWLEDGEMENT :-

The author is grateful to Anuradha College of Pharmacy, Chikhali for providing laboratory facilities and to the principal DR. R. H. Kale for his constant encouragement and guidance during the course of this study.

  1. CONFLICT OF INTRESET :-

The author declares no conflict of interest. This research receives no external funding(self-funded).

REFERENCES

  1. Gaykar DB, Tambe BD. Formulation and evaluation of  herbal tooth powder for oral care. Int. J Res Publ Rev. 2023 Jun ; (6) 1057-11061.
  2. Dudhe SB, DOIjad CR. Formulation and evaluation of herbal toothpowder. J Crit Rev. 2020;7 (18) :5008-5028.
  3. Edake VS.Formulation and evaluation of herbal toothpowder. Int. J Creat Res Thoughts.2023 May;11(5): M346-M362.
  4. Uchale PN, kumbhar ST. formulation and  evaluation of herbal tooth powder.Int J Adv Res Sci Commun Technol. 2022 Jun;2(6):59-71.
  5. Patadiya  N,Dumpala R. a high –profile review on new oral cloting factor Xa inhibitor: betrixaban.. Eur J Pharm Med Res.2021;8(1):239-247.
  6.  kolekar  T, Patadiya N. Dissolution enhancement technique:self-emulsifying drug delivery system (SEDDS). Int J Inst Pharm Life Sci.2020;10(6):25-39.
  7. Kolekar T, Patadiya N. Self emulsifying drug delivery system (SEDDS): A novel dissolution enhancement technique. Int. J  Trend Innov Res.2020;2(5):10-20.
  8. Nikunj P, Shilpa P,Pooja M,Prikan . Preparation and  standardization of chitrakadi vati. J pharm Sci Innov.2022;11(3):28-35.DOI:10.7897/2277-4572.113230.
  9. Patel  S, Patadiya N .praparation and  standardization of Ayurvedic Nindra Vati. Int J Pharm Sci. 2024;2(2):403-409. DOI 10.5281/zenodo.10673390.
  10. Patel S, Patadiya N, Patel A . Formulation and evaluation of  turmeric and coriander-based herbal nail  polishesh. Int J Pharm Sci. 2024;2(2):488-495.DOI:10.5281/zenodo.10679282.
  11. Makvana P,Patadiya  N, Baria D. Design, molecular docking, in-silicon ADMET prediction , synthesis and evaluation of novel quinazoline derivetives as factor Xa inhabitors.Int Res J Pharm.2022;13(3):30-37.DOI:10.7897/2230-8407.1303187.
  12. Patadiya N. Stiroids: Classification, nomenclature, and stereochemistry.Int J Univ Pharm  Bio Sci.2020;9(5):28-38.
  13. Patel R, Darji J, Patadiya N, Thummar M. Development and evaluation of medicated chewing of raloxifene hydrochloride. Int. J Pharm Bio Sci Arch.2021;9(3):1-12.
  14. Patadiya N, Vaghela V, Padhra S. optimization of synthetic condition for 2’-Hydroxy Chalcone using mixture design.Asian J Res Chem.2023;16(6):417-422.DOI:10.52711/0974-4150.2023.00068.
  15. Soni D, Patadiya N. A  Wonderful harmone :estrogen. Int. J Pharm 02.2020;2(5):362-368.
  16. Dumpala R, Patel J Patadiya N, Patil C.Solubliti and dissolution enhancement of erlotinib by liquisolid compact technique. Int J Pharm 02.2020;2(4):271-290.
  17. Patadiya N, Vaghela V. A novel and eco-frendly method for synthesis of 3-benzylidene-2-phenylcroman-4-1analogs. Asian J Res Chem. 2022;15(3)”:195-199DOI:10.52711/0974-4150.2022.00033.
  18. Patadiya N,Vaghela V. Design, in-silico ADME study and molecular docking study of novel quinolone-4-one derivetives as factor Xa inhabitor.Asian J Pharm Res.2022;12(3):207-211DOI 10.52711/2231-5691.2022.00034.
  19. Patadiya N, Vaghela V. An efficient method for synthesis of flavanone. Asian J  Pharm Res.2022;12(3):221-224. DOI: 10.52711/2231-5691.2022.00039

Reference

  1. Gaykar DB, Tambe BD. Formulation and evaluation of  herbal tooth powder for oral care. Int. J Res Publ Rev. 2023 Jun ; (6) 1057-11061.
  2. Dudhe SB, DOIjad CR. Formulation and evaluation of herbal toothpowder. J Crit Rev. 2020;7 (18) :5008-5028.
  3. Edake VS.Formulation and evaluation of herbal toothpowder. Int. J Creat Res Thoughts.2023 May;11(5): M346-M362.
  4. Uchale PN, kumbhar ST. formulation and  evaluation of herbal tooth powder.Int J Adv Res Sci Commun Technol. 2022 Jun;2(6):59-71.
  5. Patadiya  N,Dumpala R. a high –profile review on new oral cloting factor Xa inhibitor: betrixaban.. Eur J Pharm Med Res.2021;8(1):239-247.
  6.  kolekar  T, Patadiya N. Dissolution enhancement technique:self-emulsifying drug delivery system (SEDDS). Int J Inst Pharm Life Sci.2020;10(6):25-39.
  7. Kolekar T, Patadiya N. Self emulsifying drug delivery system (SEDDS): A novel dissolution enhancement technique. Int. J  Trend Innov Res.2020;2(5):10-20.
  8. Nikunj P, Shilpa P,Pooja M,Prikan . Preparation and  standardization of chitrakadi vati. J pharm Sci Innov.2022;11(3):28-35.DOI:10.7897/2277-4572.113230.
  9. Patel  S, Patadiya N .praparation and  standardization of Ayurvedic Nindra Vati. Int J Pharm Sci. 2024;2(2):403-409. DOI 10.5281/zenodo.10673390.
  10. Patel S, Patadiya N, Patel A . Formulation and evaluation of  turmeric and coriander-based herbal nail  polishesh. Int J Pharm Sci. 2024;2(2):488-495.DOI:10.5281/zenodo.10679282.
  11. Makvana P,Patadiya  N, Baria D. Design, molecular docking, in-silicon ADMET prediction , synthesis and evaluation of novel quinazoline derivetives as factor Xa inhabitors.Int Res J Pharm.2022;13(3):30-37.DOI:10.7897/2230-8407.1303187.
  12. Patadiya N. Stiroids: Classification, nomenclature, and stereochemistry.Int J Univ Pharm  Bio Sci.2020;9(5):28-38.
  13. Patel R, Darji J, Patadiya N, Thummar M. Development and evaluation of medicated chewing of raloxifene hydrochloride. Int. J Pharm Bio Sci Arch.2021;9(3):1-12.
  14. Patadiya N, Vaghela V, Padhra S. optimization of synthetic condition for 2’-Hydroxy Chalcone using mixture design.Asian J Res Chem.2023;16(6):417-422.DOI:10.52711/0974-4150.2023.00068.
  15. Soni D, Patadiya N. A  Wonderful harmone :estrogen. Int. J Pharm 02.2020;2(5):362-368.
  16. Dumpala R, Patel J Patadiya N, Patil C.Solubliti and dissolution enhancement of erlotinib by liquisolid compact technique. Int J Pharm 02.2020;2(4):271-290.
  17. Patadiya N, Vaghela V. A novel and eco-frendly method for synthesis of 3-benzylidene-2-phenylcroman-4-1analogs. Asian J Res Chem. 2022;15(3)”:195-199DOI:10.52711/0974-4150.2022.00033.
  18. Patadiya N,Vaghela V. Design, in-silico ADME study and molecular docking study of novel quinolone-4-one derivetives as factor Xa inhabitor.Asian J Pharm Res.2022;12(3):207-211DOI 10.52711/2231-5691.2022.00034.
  19. Patadiya N, Vaghela V. An efficient method for synthesis of flavanone. Asian J  Pharm Res.2022;12(3):221-224. DOI: 10.52711/2231-5691.2022.00039

Photo
Priyal Dandade
Corresponding author

Anuradha College of Pharmacy, Chikhli, Buldana, Maharastra, India, 443201

Photo
Punam Ambhore
Co-author

Anuradha College of Pharmacy, Chikhli, Buldana, Maharastra, India, 443201

Photo
Payal Gore
Co-author

Anuradha College of Pharmacy, Chikhli, Buldana, Maharastra, India, 443201

Photo
Poonam Dalvi
Co-author

Anuradha College of Pharmacy, Chikhli, Buldana, Maharastra, India, 443201

Photo
Renuka Joshi
Co-author

Anuradha College of Pharmacy, Chikhli, Buldana, Maharastra, India, 443201

Photo
Vaishnavi Petkar
Co-author

Anuradha College of Pharmacy, Chikhli, Buldana, Maharastra, India, 443201

Photo
Dr. R. H. Kale
Co-author

Anuradha College of Pharmacy, Chikhli, Buldana, Maharastra, India, 443201

Photo
Dr. K. R. Biyani
Co-author

Anuradha College of Pharmacy, Chikhli, Buldana, Maharastra, India, 443201

Priyal Dandade, Punam Ambhore, Payal Gore, Poonam Dalvi, Renuka Joshi, Vaishnavi Petkar, Dr. R. H. Kale, Dr. K. R. Biyani, Design and Characterization of a Herbal Tooth Gum Powder for Oral Hygiene, Int. J. of Pharm. Sci., 2026, Vol 4, Issue 5, 1018-1024. https://doi.org/10.5281/zenodo.20046448

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