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Abstract

Balanites aegyptiaca, commonly known as the desert date or soapberry tree, has been traditionally used for various medicinal purposes. Balanites aegyptiaca is a widespread African medicinal plant of interest, containing several cytotoxic and cytostatic compounds. This review explores the scientific evidence regarding the potential anticancer properties of Balanites aegyptiaca. We delve into the phytochemical composition of the plant, highlighting compounds such assaponins, flavonoids, and alkaloids known for their anti-cancer activities.The the studies described here attempted to further characterize the cancer activities Current studies have also shown that it is antiproliferative by inducing apoptotic cell death we discuss the mechanisms behind these effects, including the modulation of key signaling pathways.

Keywords

Desert date, anti-cancer activity , saponin , glycoside, balanitoside

Reference

  1. Hall JB. Ecology of a key African multipurpose tree species Balanites aegyptiaca Del. (Balanitaceae): The state of knowledge. Forest Ecol Manag. 1992;50:1–30. [Google Scholar]
  2. Al-Ghannam SM, Ahmed HH, Zein N, Zahran F. Antitumor activity of balanitoside extracted from Balanites aegyptiaca fruit. Journal of Applied Pharmaceutical Science. 2013;3(7):179. [Google Scholar]
  3. Quality Standards of Indian Medicinal Plants Vol V: pg 98-107
  4. B.P. Chapagain et at Larvicidal activity of saponins from Balanites aegyptiaca callus against Aedes aegypti mosquitoBioresour. Technol.(2008)
  5. National Plant Data Center, NRCS, USDA. Baton Rouge, LA 70874-4490 USA. http://plants.usda.gov. Balanites aegyptiaca . [Google Scholar]
  6. Chothani DL, Vaghasiya H. A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity. Pharmacogn Rev. 2011;5(9):55. doi: 10.4103/0973-7847.79100. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  7. Hall JB, Waljer DH. School of Agricultural and Forest Science. Banger: University of Wales; 1991. Balanites aegyptiaca Del. A monograph; pp. 1–12. [Google Scholar]
  8. Charlemagne, et al. Balanitin-6 and -7: Diosgenyl saponins isolated from Balanites aegyptiaca Del.display significant anti-tumor activity in vitro and in vivo. Int J Oncol. 2008;32:5–15. [PubMed] [Google Scholar]
  9. Pettit GR, Doubek DL, Herald DL, Numata A, Takahasi C, Fujiki R, et al. Isolation and structure of cytostatic steroidal saponins from the African medicinal plant Balanites aegyptiaca. J Nat Prod. 1991;54:1491–502. [PubMed] [Google Scholar]
  10. Kamel MS, Koskinen A. Pregnane glycosides from fruits of Balanites aegyptiaca. Phytochemistry. 1995;40:1773–5. [PubMed] [Google Scholar]
  11. Hardman R, Wood CN, Sofowora EA. Isolation and characterization of seed hydrocarbons from balanites aegyptiaca (B.roxburghii) and B. pedicellaris. Phytochemistry. 1970;9:1087–92. [Google Scholar]
  12. Samuel AL, Temple VJ, Ladeji O. Chemical and nutritional evaluation of the seed kernel of Balanites Aegyptiaca. Niger J Biotech. 1997;8:57–63. [Google Scholar].
  13. Nour AA, Ahmed AH, Abdel-Gayoum AG. A chemical study of Balanites aegyptiaca L. (Lalob) fruits grown in Sudan. J Sci Food Agre. 1985;36:1254–8. [Google Scholar]
  14. Mohamed AM, Wolf W, Well S. Physical, morphological and chemical characteristics, oil recovery and fatty acid composition of Balanites aegyptiaca Kernels. Plant Foods Hum Nutr. 2002;57:179–89. [PubMed] [Google Scholar]
  15. Sarker SD, Bartholomew B and Nash RJ: Alkaloids from Balanites aegyptiaca. Fitoterapia 71: 328-330, 2000.
  16. Speroni E, Cervellati R, Innocenti G, Costa S, Guerra MC,Dall'Acqua S and Govoni P: Anti-inflammatory, anti-nociceptive and antioxidant activities of Balanites aegyptiaca (L.) Delile. J Ethnopharmacol 98: 117-125, 2005
  17. Hassan L, Majid A, Iqbal M, Al Suede F, Haque R, Ismail Z, Ein O, Majid A, Ahamed MBK. Crystal structure elucidation and anticancer studies of (?)-pseudosemiglabrin: a flavanone isolated from the aerial parts of tephrosia apollinea. PLoS One. 2014;9(3):90806. doi: 10.1371/journal.pone.0090806. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  18. Al Ashaal HA, Farghaly AA, Abd El Aziz MM, Ali MA. Phytochemical investigation and medicinal evaluation of fixed oil of Balanites aegyptiaca fruits (Balantiaceae) J Ethnopharmacol. 2010;127:495–501. [PubMed] [Google Scholar]
  19. Gnoula C, Mégalizzi V, De Nève N, Sauvage S, Ribaucour F, Guissou P, Duez P, Dubois J, Ingrassia L, Lefranc F. Balanitin-6 and-7: diosgenyl saponins isolated from Balanites aegyptiaca Del. display significant anti-tumor activity in vitro and in vivo. Int J Oncol. 2008;32(1):5–15. [PubMed] [Google Scholar]
  20. Al-Ghannam SM, Ahmed HH, Zein N, Zahran F. Antitumor activity of balanitoside extracted from Balanites aegyptiaca fruit. Journal of Applied Pharmaceutical Science. 2013;3(7):179. [Google Scholar]

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Pragati Padse
Corresponding author

Nandkumar Shinde College of Pharmacy, Aghur, Vaijapur 423701 Dist. - Aurangabad, Maharashtra.

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Jyoti Dhakne
Co-author

Nandkumar Shinde College of Pharmacy, Aghur, Vaijapur 423701 Dist. - Aurangabad, Maharashtra.

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Rushikesh Nikam
Co-author

Nandkumar Shinde College of Pharmacy, Aghur, Vaijapur 423701 Dist. - Aurangabad, Maharashtra.

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Pratiksha Padol
Co-author

Nandkumar Shinde College of Pharmacy, Aghur, Vaijapur 423701 Dist. - Aurangabad, Maharashtra.

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Pooja Aher
Co-author

Nandkumar Shinde College of Pharmacy, Aghur, Vaijapur 423701 Dist. - Aurangabad, Maharashtra.

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Rahul Polke
Co-author

Nandkumar Shinde College of Pharmacy, Aghur, Vaijapur 423701 Dist. - Aurangabad, Maharashtra.

Pragati U. Padse*, Jyoti R. Dhakne, Rushikesh A. Nikam, Pratiksha K. Padol, Pooja N. Aher, Rahul G. Polke Anti-Cancer Activity Of Balenites Aegyptiaca, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 12, 482-487. https://doi.org/ 10.5281/zenodo.10400854

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