View Article

  • Benzotriazole Derivatives And Its Pharmacological Activity

  • *1Student Department of Pharmaceutical Chemistry, Late Bhagirathi Yashwantrao Pathrikar College of Pharmacy, India
    2Assistant Professor Department of Pharmaceutical Chemistry, Late Bhagirathi Yashwantrao Pathrikar College of Pharmacy, India
    3Principal Department of Pharmaceutical Chemistry, Late Bhagirathi Yashwantrao Pathrikar College of Pharmacy, India
     

Abstract

Azoles are heterocyclic chemicals that were first identified in late 1960 and make up the largest class of currently accessible antifungal medications. A particular chemical element that gives azoles their activity is the imidazole ring. Triazoles are made by making a small alteration to this ring, and derivatives of triazoles have been found to have equal or better actions as well as fewer negative effects. It follows that the discovery of biological activity in benzimidazole/benzotriazole compounds is not unexpected. Due to the extensive research on benzimidazole, the focus of this review is on defining the role of benzotriazole derivatives in biomedical research, highlighting their diverse biological characteristics, the mechanism of action, and Structure Activity Relationship (SAR) studies for a variety of antimicrobial, antiparasitic, and even antitumor, cholesterol-lowering agents.

Keywords

Benzotriazole, Antimicrobial, Antioxidative, Antibercular, Antiviral, Anti-inflammatory

Reference

  1. Briguglio, S. Piras, P. Corona, E. Gavini, M. Nieddu, G. Boatto, A. Carta, “Benzotriazole: An overview on its versatile biological behavior”. Bhavior! European Journal of Medicinal Chemistry [2014] page no. 1-37
  2. B.V. Suma FI, N.N. Nitesh and V.madhavan "Benzotriazole in medicinal Chemistry An overview". I. Chem. Pharm Res[2011]Page no-375-381
  3. A. vahad Datta, Asnani Alpana, mohurl Shrikant, Kumar Praitysh, Bais Abhinav and Tale Ruchita, “Review on Synthetic Study of Benzotriazole” GSC Biological and Pharmaceutical sciences[2020] Page No-205-225
  4. Koen H.G Verschuren, Ksenia Pumpor, Anemuller, Shuai Chen, Jearea R. Mester, Rolef Hilgenfeld, “A Structural view of the inactivation OF the SARS Coronavirus main Proteinase by Benzotriazole Esters”. Chemistry & Biology (2008)
  5. Ibba, R.; Corona, P.; Nonne,F.; Caria, P.; Serreli, G.; Palmas, V. Riu, F.; Sestito, S.; Nieddu, M.; Loddo, R.; et al. Design, Synthesis, andAntiviral Activities of New Benzotriazole-Based Derivatives.Pharmaceuticals 2023, 16, 429.https://doi.org/10.3390/ph16030429
  6. Suyash Yadhav, Pushpendra kumar jain, Abhinav parson Mishra, ankit Bajpai “ Pharmacological activites and activation  as well as comparison of benzotriazole with other groups” Indian journal of pharmacy and pharmacology[2022] 207-251
  7. Rangappa S. Keri, Mahadeo R. Patil, Siddappa A. Patil, Srinivasa Budagumpi, “A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry”. European Journal of Medicinal Chemistry 89 (2015) 207-251 http://dx.doi.org/10.1016/j.ejmech.2014.10.059
  8. Prabodh Chander Sharma, Alka Sinhmar, Archana Sharma, Harish Rajak & Dharam Pal Pathak (2013) Medicinal significance of benzothiazole scaffold: an insight view, Journal of Enzyme Inhibition and Medicinal Chemistry, 28:2, 240-266, DOI: 10.3109/14756366.2012.720572
  9. Raju R. Kale, Virendra Prasad Prabhu, P. Mohapatra ,Vinod K. Tiwari, “ Recent developments in benzotriazole methodology for construction of pharmacologically important heterocyclic skeletons”. Monatsh Chem (2010) 141:1159–1182 DOI 10.1007/s00706-010-0378-1
  10. Ibba R, Piras S, Corona P, Riu F,Loddo R, Delogu I, Collu G, Sanna G,Caria P, Dettori T and Carta A (2021) Synthesis, Antitumor and Antiviral In Vitro Activities of New Benzotriazole-Dicarboxamide Derivatives. Front. Chem. 9:660424. doi:10.3389/fchem.2021.660424
  11. Loukopoulos, E., & Kostakis, G. (2019). Recent advances in the coordination chemistry of benzotriazole- based ligands (Version 1). University of Sussex.
  12. Alan R. Katrizky, Scott A. Henderson and Baozen Yang, “Application of Benzotriazole Methodology in heterocyclic Ring Synthesis and substituent Introduction and Modification”, J. Heterocyclic Chem. 35, 1123 [1998]
  13. Zhou-Qi Shi, You-Sheng Liu, Qian Xiong, Wen-Wen Cai, Guang-Guo Ying, "Occurrence, toxicity and transformation of six typical benzotriazoles in the environment: A review", Science of the Total Environment 661 (2019) 407–421.
  14. ANEES A. KHADOM,APRAEL S. YARO, AND ABDUL AMIR H. KADHUM, "ADSORPTION MECHANISM OF BENZOTRIAZOLE FOR CORROSION INHIBITION OF COPPER-NICKEL ALLOY IN HYDROCHLORIC ACID", J. Chil. Chem. Soc., 55, Nº 1 (2010).
  15. Gujar A. S, Danao K. R. and Mahajan U. N. Benzotriazole, its derivatives and antibacterial activity: An overview International Journal of Pharmaceutical Chemistry 2020; 10(3): e5474. Doi: 10.7439/ijpc.v10i3.5474 Available from: https://ssjournals.com/index.php/ijpc/article/view/5474
  16. Khalafi A, Zare A, Parhami A, Soltani Rad MN and Nejabat GR. (2007), “Highly regioselective N-alkylation of benzotriazole under solvent-free conditions”, J. Iranian Chem. Soc, 4(3),271-278.
  17. Namdeo KP, Singh VK and Prajapati SK, “Synthesis of some 2-(substituted)-5-[(N-benzotriazolomethyl)-1,3,4-thiadiazolyl]-4-thiazolidinones for their antifungal activity”. Indian J. Pharma. Educ. Res, (2009), 43(3), 266-271.
  18. Aiyalu Rajasekaran, Kalasalingam Ananda Rajagopal, “ Synthesis of some novel triazole derivatives as anti-nociceptive and anti-inflammatory agents” . Acta Pharm. 59 (2009) 355–364.
  19. V K Singh, PoonamRishishwar, Peeyush Bhardwaj and ShashiAlok. (2017),“Benzotriazole: A Heterocyclic Molecule with Diversified Pharmacological Activities” .IJPSR, 8(2), 446-456.
  20. Paolo Sanna, Antonio Carta, Mohammad E. Rahbar Nikookar, “Synthesis and antitubercular activity of 3-aryl substituted-2-(1H(2H)benzotriazol-1(2)-yl)acrylonitriles” Eur. J. Med. Chem. 35 (2000) 535?543

Photo
Aniket Dandge
Corresponding author

Student Department of Pharmaceutical Chemistry, Late Bhagirathi Yashwantrao Pathrikar College of Pharmacy, India

Photo
Shubhangi Manikpuriya
Co-author

Assistant Professor Department of Pharmaceutical Chemistry, Late Bhagirathi Yashwantrao Pathrikar College of Pharmacy, India

Photo
Gajanan Sanap
Co-author

Principal Department of Pharmaceutical Chemistry, Late Bhagirathi Yashwantrao Pathrikar College of Pharmacy, India

Aniket Dandge*, Shubhangi Manikpuriya, Gajanan Sanap, Benzotriazole Derivatives And Its Pharmacological Activity, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 12, 948- 957. https://doi.org/10.5281/zenodo.10443937

More related articles
Formulation and Evaluation of Anti-inflammatory Cr...
Jadhav Ashvini , Jadhav Ritesh, Dr. Vaishali Kate, Dr. Santosh Pa...
Fennel: Your Home's Healing Herb - Remedies That W...
Saurabh Shrihari Raghute, Saurabh Rajesh Thadani, Meenal Yogeshwa...
Formulation And Evaluations Of Alfalfa Tablet...
Vaishnavi Prakash Lande , Harishkumar Rathod , Swati Deshmukh , S...
Review Paper on Anti Acne Properties of Winter Green Leaves and Cucumber Peels...
Niddhi Akarshe, Suvidha Kabadi, Gauri Mahajan , Riten Solanki , Disha Shinde, ...
Fennel-Powered Elegance: Formulation, Evaluation, and Future Horizons of Peel-of...
Tanmayee Zade, Radhika Gupta, Ruchika S. Sawarkar, Dr. Dinesh Biyani, Milind Umekar, ...
Related Articles
Medicago Sativa: A Potential Health Plant An Overview...
Yash Vikhankar, Vaibhav Gabhale, Kaushal Patil , Tanmayi Patil , ...
Commencement Scrutiny Of 1,3,4-Oxadiazole; Its Visceral Activities ...
Rachel Mathew, V .S. Anjana , Ayoona Najeeb , Fathima Shereen S, Nikhila Anna Anil , Sarin Santhosh,...
Heterocyclic 1, 3, 4-Oxadiazole Compounds with Diverse Biological Activities - A...
Nikita Gaikwad, Dinesh Kawade, Dhananjay Tidke, Shubham Khandare, Sneha Nandeshwar, ...
The Role of Chalcones in Modern Medicinal Chemistry: A Review of Their Potential...
Sukanta Debnath, Saurabh Kumar Das, Jasvinder Singh, Naiyar Alam, Beauty Kumari, Niharjyoti Saharia,...
Formulation and Evaluation of Anti-inflammatory Cream by Using Moringa Oleifera ...
Jadhav Ashvini , Jadhav Ritesh, Dr. Vaishali Kate, Dr. Santosh Payghan, ...
More related articles
Formulation and Evaluation of Anti-inflammatory Cream by Using Moringa Oleifera ...
Jadhav Ashvini , Jadhav Ritesh, Dr. Vaishali Kate, Dr. Santosh Payghan, ...
Fennel: Your Home's Healing Herb - Remedies That Work ...
Saurabh Shrihari Raghute, Saurabh Rajesh Thadani, Meenal Yogeshwar Katre, Trivedi Rashmi, Chandak Ka...
Formulation And Evaluations Of Alfalfa Tablet...
Vaishnavi Prakash Lande , Harishkumar Rathod , Swati Deshmukh , Saloni S. Bangar, ...
Formulation and Evaluation of Anti-inflammatory Cream by Using Moringa Oleifera ...
Jadhav Ashvini , Jadhav Ritesh, Dr. Vaishali Kate, Dr. Santosh Payghan, ...
Fennel: Your Home's Healing Herb - Remedies That Work ...
Saurabh Shrihari Raghute, Saurabh Rajesh Thadani, Meenal Yogeshwar Katre, Trivedi Rashmi, Chandak Ka...
Formulation And Evaluations Of Alfalfa Tablet...
Vaishnavi Prakash Lande , Harishkumar Rathod , Swati Deshmukh , Saloni S. Bangar, ...