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Abstract

The aim and objective of the present study was to formulate and evaluate Ketoconazole Nanoparticle. Prepared Ketoconazole loaded zinc oxide nanoparticle. The prepared Nanoparticle formulation was evaluated for particle size and Polydispersity index. The prepared Nanoparticle further formulation gel was prepared with Carbopol 934 and Carbopol 940 Polymers. The honey used as antimicrobial and antifungal agent. The prepared Formulation was evaluated Drug content, viscosity. Spreadability, pH, In vitro Drug release study and Stability studies, antifungal activity. Particle size analysis showed that the average particle size of Ketoconazole Nanoparticle using ethyl cellulose was found to be 369.2 nm with Poly Dispersity Index (PDI) value 0.291. The drug content of all formulations was in the range of 86% to 96%. The in-vitro drug release of optimized batch F3 showed the maximum drug release of 96% in 12 hr. Viscosity was 3567 cps. The Antifungal activity result Showed more zone of inhibition in honey containing gel. Optimized Batch F3 formulation was subjected to stability studies for 3 months, it could be concluded that formulation was stable after 3-months stability study.

Keywords

Ketoconazole, Nanoparticle, Carbopol 934, Carbopol 940, Topical gel, Antifungal activity

Reference

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Vasudev Jitendra Sharma
Corresponding author

Department of Pharmaceutics, Ali Allana College of Pharmacy, Akkalkuwa, Nandurbar-425415, MH, INDIA

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Mayur Gokul Jayswal
Co-author

Department of Pharmaceutics, Ali Allana College of Pharmacy, Akkalkuwa, Nandurbar-425415, MH, INDIA

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Raza Khan
Co-author

Department of Pharmaceutics, Ali Allana College of Pharmacy, Akkalkuwa, Nandurbar-425415, MH, INDIA

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Dr. Mohd. Rehan Deshmukh
Co-author

Department of Pharmaceutics, Ali Allana College of Pharmacy, Akkalkuwa, Nandurbar-425415, MH, INDIA

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Prof. (Dr.) G. J. Khan
Co-author

Department of Pharmaceutics, Ali Allana College of Pharmacy, Akkalkuwa, Nandurbar-425415, MH, INDIA

Vasudev Jitendra Sharma*, Mayur Gokul Jayswal, Raza Khan, Dr. Mohd. Rehan Deshmukh, Prof. (Dr.) G. J. Khan, Formulation And Evaluation Of Gel Containing Zinc Oxide Nanoparticle Of Ketoconazole With Aqueous Honey Solution, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 10, 44-53. https://doi.org/10.5281/zenodo.8419318

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