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Abstract

Benzimidazole derivative are very useful intermediates or subunits of the development of pharmaceutical or biological interest. Benzimidazole derivative are an important class of bioactive molecules in the field of drugs and pharmaceuticals. It is worth noting that most of the different chemical derivatives of benzimidazole play an effective and critical role in the medical field as a distinct treatment for many different diseases, for example anti-all types of infections. Albendazole is an anthelmintic that was recommended by the WHO to treat soil transmitted helminth infections. ABZ shows a broad spectrum of activity in domestic animals and was subsequently licensed for human use in 1982.Because of its effectiveness, safety and low price, ABZ is one of the main drugs used in PC programs. The excellent safety record of ABZ is related to its mechanism of action, which involves selective binding to ?tubulin and disruption of microtubule polymerization. Computer models are suitable substitutes for experimentation in such cases. The ten compounds were virtually screened with the protein target (PDB Code: 7ERI) to find potential lead candidates based on docking scores and residual interactions using molecular docking experiments. Lastly, the compounds' physicochemical characteristics were created in order to investigate their drug-likeness and pharmacokinetic profiles.

Keywords

Benzimidazole, Molecular docking, Simulation, Albendazole, Microtubule Polymerisation etc

Reference

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Sandip S. Chaudhari
Corresponding author

Shri Prakashchand Jain College of Pharmacy and Research, Palaskheda (Bk), Jamner 424205 Maharashtra, INDIA.

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Megha R. Mahajan
Co-author

Shri Prakashchand Jain College of Pharmacy and Research, Palaskheda (Bk), Jamner 424205 Maharashtra, INDIA.

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Puja R. Khodape
Co-author

Shri Prakashchand Jain College of Pharmacy and Research, Palaskheda (Bk), Jamner 424205 Maharashtra, INDIA.

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Diksha N. Koli
Co-author

Shri Prakashchand Jain College of Pharmacy and Research, Palaskheda (Bk), Jamner 424205 Maharashtra, INDIA.

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Tarannum R. Sayyyad
Co-author

Shri Prakashchand Jain College of Pharmacy and Research, Palaskheda (Bk), Jamner 424205 Maharashtra, INDIA.

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Prashant P. Nikumbh
Co-author

Shri Prakashchand Jain College of Pharmacy and Research, Palaskheda (Bk), Jamner 424205 Maharashtra, INDIA.

Megha R. Mahajan, Puja R. Khodape, Diksha N. Koli, Tarannum R. Sayyad, Sandip S. Chaudhari*, Prashant P. Nikumbh, In Silico Design And ADME Study Of Novel Benzimidazole Containing Derivatives As Anthelmintic Agents, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 12, 71-78. https://doi.org/10.5281/zenodo.10259508

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