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  • Synthetic Strategy And Pharmacological Approaches Of Benzopyrazole: A Review
  • 1PG Scholar, Department of Pharmaceutical chemistry, BLDEA’s SSM College of Pharmacy and Research centre Vijayapur-586103
    2Associate Professor, Department of Pharmaceutical Chemistry, BLDEA’s SSM College of Pharmacy and Research centre Vijayapur-586103

Abstract

Indazole-containing derivatives represent one of the most important heterocycles in drug molecules. The presence of two nitrogen sites located in adjacent positions in the molecular structure allows indazole, at low concentrations in mildly acid or basic media, to form 1H and 2H tautomers via acid-base interactions as well as symmetrical dimers by hydrogen bonding. Indazole is also known as 1H-Benzopyrazole, 2-Azaindole. Synonyms of indazoles are 1H-Indazole, 2H-indazole, Isoindazole1,2-Diazaindene and Benzopyrazole. The first compound known to contain the indazole ring system was indazole and its preparation, by heating o-hydrazinobenzoic acid was reported in 1880 by Fischer. Indazole itself was first prepared a few years later by Fischer and Kuzel. Since then, several approaches for the preparation of indazole and its derivatives have been developed. Indazole shows many biological activities like anti-cancer, anti-microbial, anti-tubercular, antioxidant, anti-platelet and neuroprotective activity. This review aims to summaries the recent method of synthesis of Indazole derivatives and advanced biological activity study of the Indazole derivatives.

Keywords

Heterocyclic compounds, Indazole, Biological activity, Pharmacological uses

Reference

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Kousalya Patil
Corresponding author

PG Scholar, Department of Pharmaceutical chemistry, BLDEA’s SSM College of Pharmacy and Research centre Vijayapur-586103

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Dr. Somashekhar M Metri
Co-author

Associate Professor, Department of Pharmaceutical Chemistry, BLDEA’s SSM College of Pharmacy and Research centre Vijayapur-586103

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Divya Shirke
Co-author

PG Scholar, Department of Pharmaceutical chemistry, BLDEA’s SSM College of Pharmacy and Research centre Vijayapur-586103

Kousalya Patil*, Dr. Somashekhar M Metri, Divya Shirke, Synthetic Strategy And Pharmacological Approaches Of Benzopyrazole: A Review, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 7, 261-268. https://doi.org/10.5281/zenodo.8161568

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