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1,2,3,5Department of Pharmaceutics, Sarada Vilas College of Pharmacy Mysuru, Karnataka, India
4Department of pharmacognosy, Sarada Vilas College of Pharmacy Mysuru, Karnataka, India
The development of rate-controlled drug delivery devices to overcome physiological barriers such as short gastric residence times and unexpected gastric emptying times has been the focus of recent technology and scientific study. The behavior of drug delivery and the duration of stomach residence are significantly impacted by variations in the gastric physiology, including motility and pH which show intra and inter-individual variability. The pharmaceutical industry has shown a great deal of interest in research on oral drug delivery, particularly with regard to the Gastro retentive drug delivery system known as the Floating Drug Delivery System (FDDS). This study goal is to analyze FDDS with an emphasis on its current advancements and future prospects. The aim of this review was to gather the latest research on floating drug delivery systems (FDDS) and to highlight the main mechanism of flotation for gastric retention. The most current advancements in FDDS are discussed in depth, along with the physiological and formulation factors influencing gastric retention, methods for designing single-unit and multiple-unit floating systems, and the characteristics of their classification and formulation. The goal of this review article is to provide comprehensive information on the pharmaceutical underpinning of floating tablet design, classification, advantages and disadvantages, and factors influencing the gastric residence time of FDDS. Floating drug delivery systems enhance both patient compliance and drug bioavailability by a prolongation of the gastric residence period and the regulation of drug release. The technological and scientific developments in floating systems are reviewed in this article
Nagendra R. , Divyashree P. , Venkatesh K. , Hanumanthachar Joshi, Nanditha V. V. , Floating Drug Delivery System: A Review, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 164-175. https://doi.org/10.5281/zenodo.10628440
10.5281/zenodo.10628440