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Abstract

Toothpaste is a paste or gel to be used with a toothbrush to maintain and improve oral health and aesthetics. Since their introduction several thousand years ago, toothpaste formulations have evolved considerably - from suspensions of crushed egg shells or ashes to complex formulations with often more than 20 ingredients. Among these can be compounds to combat dental caries, gum disease, malodor, calculus, erosion and dentin hypersensitivity. Furthermore, toothpastes contain abrasives to clean and whiten teeth, flavors for the purpose of breath freshening and dyes for better visual appeal. Effective toothpastes are those that are formulated for maximum bioavailability of their actives. This, however, can be challenging as compromises will have to be made when several different actives are formulated in one phase. Toothpaste development is by no means complete as many challenges and especially the poor oral substantivity of most active ingredients are yet to overcome.

Keywords

Toothpaste, Ingredient, Formulation, Teeth, flavor, breath freshening, Dyes, oral

Reference

  1. Winfield A.J, Richards R.M.E. Pharmaceutical practice. Churchil Livingstone, Edunburgh, London, New York, Philadelphia, San Francisco, Sydney, Toronto: 1998. pp. 421–423. [Google Scholar]
  2. Mitsui T. New cosmetic science. Elsevier, Amsterdam, Lausanne, New York, Oxford, Shannon, Tokyio: 1997. pp. 480–490. [Google Scholar]
  3. Sweetman S.C, editor. Martindale: The complete drug reference. 33rd Edition. London: Pharmaceutical Press; 2002. [Google Scholar]
  4. Bruneton J. Pharmacognosy, phytochemistry, medicinal plants. Paris: Intercept Ltd; 1999. pp. 45–52. 53-57 [Google Scholar]
  5. Matshuhiro B, Urzua C.C. Heterogeneity of carrageenans from Chondrus crispus. Phytochemistry. 1992;31:531–534. [PubMed] [Google Scholar]
  6. European Pharmacopoeia. 4th Edition. Strasbourg: Council of Europe; 2002. [Google Scholar]
  7. Becker A, Katzen F, Püshler A, Ielpi L. Xanthan gum biosynthesis and application: A biochemical/genetic perspective. Appi. Microbiol. Biotechnol. 1998;50:145–152. [PubMed] [Google Scholar]
  8. Herlofson B.B, Barkvoll P. Sodium lauryl sulfate and recurrent aphthous ulcers. A preliminary study. Acta Odont. Scand. 1994;52:257–259. [PubMed] [Google Scholar]
  9. Ciancio S.G. Dental products. In: Swarbrick J, Boylan J.C, editors. Encyclopedia of Pharmaceutical Technology. Vol. 3. New York and Basel: Marcel Dekker, Inc; 1990. pp. 425–456. [Google Scholar]
  10. Fejerskov O, Ekstrand J, Burt B.A. Fluoride in dentistry. 2nd edition. Copenhagen: Munksgard; 1996. [Google Scholar]
  11. Scheie A.A, Fejerskov O.B. Xylitol in caries prevention: what is the evidence for clinical efficacy? Oral Dis. 1998;4:268–278. [PubMed] [Google Scholar]
  12. Schemehorn B.R, Orban J.C, Wood G.D, Fisher G.M, Winston A.E. Remineralization by fluoride enhanced with calcium and phosphate ingredients. J. Clin. Dent. 1999;10:13–16. [PubMed] [Google Scholar]
  13. Legier-Vargas K, Mundorff-strestha S.A, Featherstone J.B.D, Gwinner L.M. Effects on sodium bicarbonate dentifrice on the levels of cariogenic bacteria in human saliva. Caries Res. 1995;29:143–147. [PubMed] [Google Scholar]
  14. Embery G, R?lla G. Clinical and biological aspects of dentifrices. Oxford: Oxford University Press; 1992. [Google Scholar]
  15. Moran J, Addy M, Newcombe R.G, Marlow I. A study to assess the plaque inhibitory actions of a newly formulated tri-closan toothpaste. J. Clin. Periodontol. 2001;28:86–89. [PubMed] [Google Scholar]
  16. Wåler S.M, Rølla G, Skjørland K.K, Øgaard B. Effects of oral rinsing with triclosan and sodium lauryl sulfate on dental plaque formation: apilot study. Scand. J. Dent. Res. 1993;101:192–195. [PubMed] [Google Scholar]
  17. Skåare A, Eide G, Herlofson B.B, Barkvoll P. The effect of toothpaste containing triclosan on oral mucosal desquamation. J. Clin. Periodontol. 1996;23:1100–1103. [PubMed] [Google Scholar]
  18. Rølla G, Ellingsen J.E. Clinical effects and possible mechanism of action of stannous fluoride. Int. Dent. J. 1994;44:99105. [PubMed] [Google Scholar]
  19. Giertsen E, Scheie A.A, R?lla G. Plaque inhibitition by a combination of zinc citrate and sodium lauryl sulphate. Caries. Res. 1989;23:278–283. [PubMed] [Google Scholar]
  20. Sheen S, Owens J, Addy M. The effect of toothpaste on the propensity of Chlorhexidine and cetyl pyridinium chloride to produce staining in vitro: a possible predictor of inactivation. J. Clin. Periodontol. 2001;28:46–51. [PubMed] [Google Scholar]
  21. Segreto V.A, Stevens D.P, Schulte M.C, Fortna R.H, Gerlach R.W. Safety and efficacy of novel tartar control dentifrice containing 3.3 % phyrophosphate: a controlled six-month clinical trial. J. Clin. Dent. 1998;9:26–29. [PubMed] [Google Scholar]
  22. Gaffar A, Poletka T, Afflitto J, Esposito A, Smith S. In vitro evaluations of pyrophosphate/ copolymer/NaF as an anti-calculus agent. Compend. Contin. Educ. Dent. 1987;8(Suppl):242–250. [PubMed] [Google Scholar]
  23. Sowinsky J, Ayad E, Petrone M, De Vizio W, Ellwood R, Davies R. Comparative investigation of the desensitising efficacy of a new dentifrice. J. Clin. Periodontol. 2001;28:1032–1036. [PubMed] [Google Scholar]
  24. Fridh G, Koch G. Effect of a mouthrinse containing amyloglucosidase and glucose oxidase on recurrent aphthous ulcers in children and adolescents. Swed. Dent. J. 1999;23:49–57. [PubMed] [Google Scholar]
  25. Kleber C.J, Moore M.H, Nelson B.J. Laboratory assessments of tooth whitening by sodium bicarbonate dentifrices. J. Clin. Dent. 1998;9:72–75. [PubMed] [Google Scholar]

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Anjali kanoja
Corresponding author

Nandkumar Shinde College Of Pharmacy, Aghur, Vaijapur 423701 Dist.¬-Aurangabad, Maharashtra

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Pooja ghuge
Co-author

Nandkumar Shinde College Of Pharmacy, Aghur, Vaijapur 423701 Dist.¬-Aurangabad, Maharashtra

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Pratiksha Holap
Co-author

Nandkumar Shinde College Of Pharmacy, Aghur, Vaijapur 423701 Dist.¬-Aurangabad, Maharashtra

Photo
Ashok jagdale
Co-author

Nandkumar Shinde College Of Pharmacy, Aghur, Vaijapur 423701 Dist.¬-Aurangabad, Maharashtra

Anjali. P. Kanoja*, Pooja. V. Ghuge, Pratiksha. B. Holap, Ashok Jagdale, To Formulate And Evaluate Herbal Toothpaste, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 12, 678-689. https://doi.org/10.5281/zenodo.10405575

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