Ayurvedic kadha is a traditional polyherbal decoction widely used for managing respiratory and immune-related disorders but limited by poor palatability, instability, and low patient compliance, particularly in children. This study aimed to develop and evaluate a kadha-based nutraceutical gummy as a modern, patient?friendly delivery system while retaining the therapeutic potential of the traditional formulation. A standardized kadha decoction was prepared from tulsi, ginger, cinnamon, clove, black pepper, turmeric, cardamom, and liquorice, followed by filtration and concentration. The extract was incorporated into a pectin-based gummy matrix with guar gum, natural sweeteners, flavoring agents, and preservatives, with systematic optimization of processing parameters (temperature, cooling, drying) to achieve desirable texture and stability. The optimized formulation yielded 45–50 gummies per batch with controlled pH (4.0–5.5), specific gravity (~1.25 g/mL), and moisture content <15%. Physicochemical evaluation confirmed acceptable weight variation, desirable chewiness (2–4 kgf), and uniform appearance without defects. Sensory assessment using a hedonic scale demonstrated high palatability and effective masking of kadha bitterness, indicating improved acceptability for pediatric use. Microbial quality and preliminary stability under controlled storage conditions supported the safety and practicality of the product. Overall, the developed kadha-based herbal gummies represent a feasible, child-friendly, and standardized dosage form that bridges traditional Ayurvedic practice with modern nutraceutical formulation for respiratory wellness.
Ayurvedic Kadha, Herbal Nutraceutical Gummies, Pediatric Drug Delivery, Polyherbal Formulation, Respiratory Wellness.
Ayurvedic Kadha is a traditional herbal decoction that has long been valued for its therapeutic efficacy in managing respiratory and immune-related disorders. In older times it was used as a treatment for colds, cough and throat irritation. Recent research highlights the transition from classical decoctions to modern dosage forms such as tablets and novel delivery systems, aiming to improve patient compliance, stability, and standardization while retaining therapeutic benefit (Panda & Das, 2025). Polyherbalism—a hallmark of Ayurveda—leverages synergistic effects among multiple herbs, enhancing efficacy and reducing toxicity (Parasuraman et al., 2014). Modern analytical techniques (e.g., HPTLC, LC-MS) are increasingly used for quality control and standardization, addressing challenges of batch-to-batch consistency and global acceptance (Sahare et al., 2025). Innovations such as dispersible tablets and moringa-based kadha tablets demonstrate improved solubility, palatability, and consumer acceptability compared to traditional preparations (Khemariya et al., 2023). However, the integration of advanced drug delivery systems (e.g., nanoformulations, sprays) remains an emerging area with significant potential for further research (Kumari et al., 2022). This review synthesizes current literature on the modernization of Kadha formulations, focusing on ingredient analysis, standardization methods, formulation development (including gummies), physicochemical characterization, in vitro efficacy assessment, and sensory evaluation.
- LITERATURE REVIEW:
The shift towards gummy-based drug delivery systems in nutraceuticals offers a patient-centric alternative to traditional oral forms, particularly beneficial for pediatric and geriatric populations due to enhanced palatability and ease of administration (Raut et al., 2026). This growing market for nutraceutical gummies reflects an increased consumer awareness regarding preventive healthcare and a preference for convenient, yet effective, health supplements (Kurian et al., 2025). This trend extends to the incorporation of traditional herbal remedies, such as Ayurvedic kadhas, into gummy matrices to enhance compliance while retaining their therapeutic benefits (Patel et al., 2025). The formulation of such herbal gummies necessitates careful consideration of gelling agents, plasticizers, and pH modifiers to ensure both physicochemical stability and the sustained bioactivity of the incorporated botanical extracts (Yadav et al., 2024). For instance, prior research has demonstrated the successful development of herbal gummies incorporating ingredients like licorice, ginger, and tulsi, which maintained acceptable organoleptic and physicochemical properties (Khune et al., 2024). The successful transformation of these complex herbal formulations into stable gummy dosage forms, therefore, represents a significant advancement in nutraceutical product development, addressing challenges related to taste masking, ease of consumption, and dose accuracy (Wavhal et al., 2025). This study aims to address these multifaceted challenges by developing an Ayurvedic kadha gummy, meticulously formulating it with a blend of traditional herbs and modern excipients to optimize therapeutic retention and consumer appeal (G et al., 2025). Specifically, this research will focus on integrating a precise combination of tulsi, ginger, cinnamon, clove, black pepper, turmeric, cardamom, and liquorice within a pectin and guar gum matrix, stabilized with potassium sorbate and sweetened with stevia, to ascertain the optimal formulation for therapeutic efficacy and stability (Karande et al., 2025). This investigation will delve into the rheological behavior and stability profiles of the formulated gummies, correlating these physicochemical attributes with the preservation of bioactive compounds from the herbal blend (Andarifera et al., 2025). This will involve comprehensive analytical techniques to quantify key phytochemicals and in vitro assays to evaluate their preserved biological activities.
3. MATERIALS AND METHODS
3.1 Materials Required
- Herbs (Tulsi, Turmeric, Ginger, Black pepper, Cinnamon, Clove, Green cardamom, Liquorice, Black cardamom)
- Solvent: Distilled water
- Decoction
- Heating mantle
- Beaker
- Filter paper, Funnel
The experimental design will encompass the systematic evaluation of various processing parameters, including cooking temperature, cooling rates, and drying conditions, to optimize the physical characteristics and shelf life of the gummy formulations. Furthermore, a comprehensive stability study will be conducted under various environmental conditions to assess the degradation kinetics of the active compounds and the overall integrity of the gummy matrix over time. This rigorous approach will ensure that the developed gummy formulations not only meet stringent quality standards but also maintain their therapeutic potency throughout their intended shelf life. The preparation of gummies is performed as follows:
3.2 Kadha Extract Preparation (45-60 minutes):
3.2.1 Herb Pre-treatment (5 min)
- Weigh each herb accurately using an analytical balance (±0.01g)
- Wash fresh herbs (Tulsi, ginger) under running water
- Chop/grate coarsely using a mortar and pestle or grinder
- Combine all herbs in a stainless steel beaker
3.2.2 Decoction Process (30 min)
- Add 250mL distilled water (1:10 herb:water ratio)
- Place on heating mantle, heat to 100°C (rolling boil)
- Reduce to simmer (80-90°C); monitor with thermometer
- Maintain boil for 25-30 min until volume reduces to ~50mL
- Mark volume on beaker for accuracy
- Stir occasionally with glass rod to prevent charring
- Final extract: Dark brown, aromatic, viscous (~45-55mL)
3.2.3 Filtration & Concentration (10 min)
- Filter hot decoction through double muslin cloth into clean 250mL beaker
- Press residue gently to extract the maximum amount of liquid
- Secondary filtration: Buchner funnel with Whatman No.1 paper
- Concentrate on water bath (60°C) if needed to exactly 50mL
- Cool to 55-60°C (warm, fingertip test)
- Record pH (target 4.5-6.0); adjust later with citric acid
3.3. Formulation & Mixing (15 minutes):
3.3.1 Base Mixing (5 min)
- In a 250mL beaker, place Kadha extract (50mL, 60°C) on magnetic stirrer
- Slowly add gelatin/pectin solution dropwise while stirring (300 rpm)
- Maintain temperature 60-65°C throughout
3.3.2 Ingredient Addition Sequence (8 min)
- Time 0 min: Sweetener - 20g warm honey/jaggery syrup
- Time 2 min: Citric acid - 0.2g (dissolved in 1mL water)
- Time 4 min: Flavour - 0.5mL mint essential oil (using a pipette)
- Time 6 min: Colour - turmeric oleoresin
- Time 8 min: Final homogeneity check - no visible separation
3.3.3 Quality Check before Molding
- Visual: Uniform amber-brown colour; no lumps
- Temperature: 65-75°C (ideal pouring viscosity)
- pH: 4.0-5.5 (meter reading)
- Specific gravity: ~1.25 g/mL
3.4 MOLDING & SETTING (3 hours):
3.4.1 Mold Preparation (2 mins)
- Lightly spray silicone molds with coconut oil to prevent sticking.
- Place on level tray, tap to remove excess oil
3.4.2 Pouring (5 mins)
- Pour the mixture slowly using a silicone spatula, filling to 95% capacity.
- Tap molds firmly 5-10 times on the counter to remove air bubbles.
- Clean spills immediately with warm water
3.4.3 Setting (2-3 hours)
- For pectin, refrigerate at 4°C for 1.5-2 hours.
- Check for a firm bounce-back when pressed.
3.4.4 Demoulding & Drying (24 hours)
- Bring to room temperature for 30 mins to prevent sweating.
- Gently flex molds, and gummies pop out easily
- Use desiccators (with fan, at 25°C, for 24 hours).
- Final moisture: <15% (non-sticky surface).
4. FORMULATION TABLE:
|
Sr. No.
|
Ingredients
|
F1
|
F2
|
F3
|
F4
|
|
1
|
Tulsi
|
5-6g
|
5-6g
|
5-6g
|
5-6g
|
|
2
|
Ginger
|
2g
|
2g
|
2g
|
2g
|
|
3
|
Turmeric
|
0.5g
|
0.5g
|
0.5g
|
0.5g
|
|
4
|
Black pepper
|
2 seeds
|
2 seeds
|
2 seeds
|
2 seeds
|
|
5
|
Cinnamon
|
0.5g
|
0.5g
|
0.5g
|
0.5g
|
|
6
|
Clove
|
1 piece
|
1 piece
|
1 piece
|
1 piece
|
|
7
|
Green cardamom
|
½ pod
|
½ pod
|
½ pod
|
½ pod
|
|
8
|
Licorice (Mulethi)
|
0.5g
|
0.5g
|
0.5g
|
0.5g
|
|
9
|
Black cardamom
|
½ pod
|
½ pod
|
½ pod
|
½ pod
|
|
10
|
Distilled water
|
250ml
|
250ml
|
250ml
|
250ml
|
|
11
|
Pectin
|
0.5g
|
2.5g
|
2.5g
|
3g
|
|
12
|
Agar agar
|
0.5g
|
2.5g
|
2.5g
|
2.5g
|
|
13
|
Stevia/jaggery/honey
|
10g (stevia)
|
5 ml (honey)
|
9g (stevia)
|
15-20g (jaggery)
|
|
14
|
Citric acid
|
0.1g
|
0.1g
|
0.1g
|
0.1g
|
|
15
|
Peppermint oil / mint
|
3-4 leaves
|
3-4 leaves
|
3-4 leaves
|
2 drops (peppermint oil)
|
|
16
|
Sodium benzoate
|
-
|
0.03g
|
0.05g
|
0.05g
|
|
17
|
Sorbitol
|
0.05g
|
2.5g
|
2.5g
|
2.5g
|
|
Sr. No.
|
Parameter
|
F1
|
F2
|
F3
|
F4
|
|
1
|
Appearance
|
Flat, liquid-like, with no proper shape
|
Partially set, round
|
Round dome-shaped was achieved
|
Smooth, shiny surface; uniform shape
|
|
2
|
Texture
|
Light brownish
|
Light peach brown
|
Peach orange
|
Dark olive brown
|
|
3
|
Odour
|
Pungent, earthy, and sweet
|
Pungent, spicy
|
A strong, pungent, minty aroma
|
Aromatic blend of warm spices and herbs
|
|
4
|
Taste
|
Tangy taste
|
Bitter
|
Tangy taste
|
Sweet and mentholated
|
|
5
|
Syneresis
|
Severe
|
Moderate
|
Acceptable
|
None
|
|
6
|
Demoulding
|
Failed
|
Failed
|
Sticky, tearing, and not a clean demould
|
Clean demould
|
|
7
|
Overall result
|
Fail
|
Poor
|
Acceptable
|
Good
|
In this study, the kadha-based herbal gummies were successfully studied. All selected Ayurvedic herbs were identified, authenticated, and evaluated organoleptically. The raw herbal ingredients such as Tulsi, Ginger, Turmeric, and spices were found to be clean, dry, and free from visible impurities. The herbs exhibited characteristic color, aroma, and taste, confirming their suitability for kadha preparation. Kadha in its traditional liquid form was noted to have a strong aroma and bitter taste, which may lead to poor acceptability, especially in pediatric patients.
The optimized process yielded 45–50 uniform gummies per batch, with controlled pH (4.0–5.5), specific gravity (~1.25 g/mL), and moisture content below 15%, ensuring suitable texture and reduced stickiness.
Quality tests confirmed acceptable weight variation (±5%), desirable chewiness (hardness 2–4 kgf), and good physical appearance without cracks or air bubbles. Sensory evaluation on a hedonic scale indicated high palatability and effective masking of kadha’s bitterness, supporting improved patient acceptability, especially for children. Microbial limits and stability considerations, supported by appropriate packaging and storage at 25°C with low humidity, suggest that the developed kadha-based herbal gummies are a feasible, child-friendly nutraceutical alternative to traditional liquid kadha for respiratory wellness.
- DISCUSSION:
This transformation into a gummy dosage form significantly enhances patient compliance, particularly among pediatric populations, by addressing the inherent palatability challenges associated with traditional herbal decoctions (Dhatchnamoorthy, 2026). This approach not only improves organoleptic properties but also potentially extends the shelf life and convenience of administration for these complex Ayurvedic formulations (Teixeira?Lemos et al., 2021). Further investigation into the precise mechanisms by which the gummy matrix preserves the bioavailability and bioactivity of the multifaceted herbal constituents is warranted, as this could elucidate novel stabilization pathways for other traditional medicine systems. Such advancements align with the growing demand for palatable and convenient herbal preparations, especially for conditions like cough and cold, where traditional remedies often face compliance issues (Gaikwad, 2025). This relevance is heightened given the increased global interest in herbal therapies due to the recognized risks and limitations of conventional medicine (Oberai et al., 2025). Medicated gummies offer a patient-centric evolution in drug delivery, providing a palatable and easily administered alternative to traditional tablets and capsules, which significantly enhances patient adherence, particularly in pediatric, geriatric, and dysphagic populations (Khadri et al., 2025). The innovative delivery system capitalizes on the increasing global market for gummies, which reached USD 16.28 billion in 2020, by integrating prebiotics and other health-enhancing compounds to meet contemporary health demands without compromising organoleptic qualities or shelf life for at least six months (Dey & Sheth, 2023). This trend underscores the potential for Ayurvedic gummy formulations to bridge the gap between traditional efficacy and modern pharmaceutical demands, especially given the established success of gummy formulations in delivering various active pharmaceutical ingredients and nutraceuticals in a palatable format (Harshitha et al., 2025). The re-engineering of Ayurvedic formulations into gummy forms addresses key challenges associated with traditional liquid dosages, such as poor palatability and inconvenient administration, thus enhancing patient acceptance and adherence, particularly for chronic conditions and preventative health (Tanaka et al., 2023). Such modernization aligns with the World Health Organization's strategy to integrate traditional medicine systems with contemporary healthcare frameworks, thereby improving accessibility, affordability, and overall well-being (Jalalpure, 2025).
- CONCLUSION
The present research successfully developed and evaluated kadha-based herbal nutraceutical gummies as a modern, palatable alternative to traditional liquid kadha for respiratory wellness. The selected Ayurvedic herbs (Tulsi, Ginger, Turmeric, spices, and Mulethi) were appropriately identified, authenticated, and found suitable for decoction preparation, exhibiting their characteristic color, aroma, and taste. Transformation of the bitter, strongly aromatic kadha into a chewable gummy format demonstrated feasibility, with excipients such as gelatin/pectin, jaggery/honey, and citric acid compatible with the herbal extract and suitable for an acceptable chewable dosage form.
Overall, the formulation concept demonstrated promise for improving palatability, ease of administration, and patient compliance, especially in children, compared with conventional kadha. The study indicates that kadha-based gummies can serve as a novel, child?friendly nutraceutical dosage form with potential as a natural supplement for cough, cold, and mild respiratory discomfort, and provides a foundation for future detailed stability, in vitro and clinical acceptability studies to support large?scale application.
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- Dey, K., & Sheth, M. (2023). Development of Galactooligosaccharide (GOS) added gummies: sensory, characterization and shelf quality. Food Production Processing and Nutrition, 5(1). doi:10.1186/s43014-022-00117-w
- Dhatchnamoorthy, D. (2026). FORMULATION AND EVALUATION OF NUTRACEUTICAL GUMMIES CONTAINING HERBAL EXTRACTS. Zenodo (CERN European Organization for Nuclear Research). doi:10.5281/zenodo.19046145
- Dhatchnamoorthy, D. (2026). FORMULATION AND EVALUATION OF NUTRACEUTICAL GUMMIES CONTAINING HERBAL EXTRACTS. Zenodo (CERN European Organization for Nuclear Research). doi:10.5281/zenodo.19046146
- G, E., Thirumalaiselvi, K., & Babu, C. (2025). An Analysis of Microbiological Quality and Bioactive Compounds for Preparing Immune Boosting Gummies. Journal of Advances in Microbiology, 25(7), 59-64. doi:10.9734/jamb/2025/v25i7958
- Gaikwad, M. (2025). A Review: Herbal Antitussive Chocolate. International Journal for Research in Applied Science and Engineering Technology, 13(4), 5823-5828. doi:10.22214/ijraset.2025.69004
- Gawande, S., Ghadge, A., & Palshikar, G. (2025). A comprehensive review on medicinal gummies for gastrointestinal relief. International Journal of Pharmacognosy and Pharmaceutical Research, 7(1), 94-98. doi:10.33545/26647168.2025.v7.i1b.100
- Harshitha, S., Keerthy, H., Zohmingliani, R., Deepak, H., & Prajwal, A. (2025). Development and evaluation of nutrient enriched gummies for pediatric immune support and bone health. Biochemical and Cellular Archives/Biochemical and cellular archives, 25(2), 2049-2060. doi:10.51470/bca.2025.25.2.2049
- Jalalpure, S. (2025). Integrating Traditional Medicine with Modern Drug Delivery Systems: A Path Forward for Holistic Health Care. INDIAN JOURNAL OF AYURVEDA & INTEGRATIVE MEDICINE KLEU, 6(1), 1-3. doi:10.4103/ijaim.ijaim_28_25
- Karande, V., Kale, S., & Pawar, T. (2025). “A critical review of herbal-infused chocolate: health benefits and nutritional value”. International Journal of Pharmaceutical Research and Applications, 10(3), 1126-1141. doi:10.35629/4494-100311261141
- Karole, S., Shrivastava, S., Thomas, S., Soni, B., Khan, S., Dubey, J., . . . Jain, D. (2019). Polyherbal Formulation Concept for Synergic Action: A Review. Journal of Drug Delivery and Therapeutics, 453-466. doi:10.22270/jddt.v9i1-s.2339
- Kean, E., & Adeleke, O. (2023). A child-friendly anti-infective gummy formulation: Design, physicochemical, micromechanical, and taste sensory evaluation. Drug Delivery and Translational Research, 14(5), 1319-1337. doi:10.1007/s13346-023-01464-y
- Khadri, F., K, K., Venkatesh, V., & joshi, H. (2025). Science and Challenges in Formulating Gummies as a Novel Oral Dosage Form: A Review. GSC Biological and Pharmaceutical Sciences, 33(3), 298-307. doi:10.30574/gscbps.2025.33.3.0521
- Khadri, F., Kulkarni, P., Venkatesh, V., & joshi, H. (2025). Science and Challenges in Formulating Gummies as a Novel Oral Dosage Form: A Review. Zenodo (CERN European Organization for Nuclear Research). doi:10.5281/zenodo.18409268
- Khadri, F., Kulkarni, P., Venkatesh, V., & joshi, H. (2025). Science and Challenges in Formulating Gummies as a Novel Oral Dosage Form: A Review. Zenodo (CERN European Organization for Nuclear Research). doi:10.5281/zenodo.18409269
- Khemariya, P., Agrawal, A., & Minnoor, E. (2023). Formulation of Dispersible Ayurvedic Kadha Tablet for the Management of Cold and Cough. Japanese Journal of Medical Research, 1(1). doi:10.33425/2993-6799.1004
- Khune, A., Rathod, H., & Deshmukh, S. (2024). Development of herbal medicated gummies for nicotine cessation support. GSC Biological and Pharmaceutical Sciences, 28(2), 84-89. doi:10.30574/gscbps.2024.28.2.0213
- Kotmire, S., Desai, A., & Chougule, N. (2024). The advances in polyherbal formulation. Journal of Pharmacognosy and Phytochemistry, 210-221. doi:10.22271/phyto.2024.v13.i1c.14828
- Kumari, S., Goyal, A., Gürer, E., Yapar, E., Garg, M., Sood, M., & Sindhu, R. (2022). Bioactive Loaded Novel Nano-Formulations for Targeted Drug Delivery and Their Therapeutic Potential. Pharmaceutics, 14, 1091-1091. doi:10.3390/pharmaceutics14051091
- Kurian, A., George, S., & Thomas, B. (2021). A Review on Phytochemical Characterization of Kwatha–Ayurvedic Polyherbal Formulation. Journal of Natural Remedies, 87-98. doi:10.18311/jnr/2021/25730
- Kurian, P., S, A., R, A., Najimudeen, A., Sajeev, R., & V, S. (2025). Herbal Nutraceutical Gummies: A Comprehensive Review. International Journal of Pharmacy and Pharmaceutical Research, 31(12), 614-623. doi:10.25166/ijppr.2025.31.12.65
- Kyriakoudi, A., Spanidi, E., Mourtzinos, I., & Gardikis, K. (2021). Innovative Delivery Systems Loaded with Plant Bioactive Ingredients: Formulation Approaches and Applications. Plants, 10, 1238-1238. doi:10.3390/plants10061238
- Maurya, D., & Sharma, D. (2020). Evaluation of Traditional Ayurvedic Preparation for Prevention and Management of the Novel Coronavirus (SARS-CoV-2) Using Molecular Docking Approach. ChemRxiv, 104211. doi:10.26434/chemrxiv.12110214
- Oberai, S., Chauhan, R., Mishra, R., Gaur, P., & Singh, R. (2025). Formulation and Evaluation of Herbal Lozenges. Research Journal of Pharmacy and Technology, 4415-4419. doi:10.52711/0974-360x.2025.00633
- Panda, P., & Das, B. (2025). A Comprehensive Review of Ayurvedic Pharmaceutical Dosage Forms: Historical Perspectives and Modern Innovations. Research Journal of Pharmacy and Technology, 1931-1936. doi:10.52711/0974-360x.2025.00276
- Parasuraman, S., Thing, G., & Dhanaraj, S. (2014). Polyherbal formulation: Concept of ayurveda. Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review, 8(16), 73-73. doi:10.4103/0973-7847.134229
- Patel, V., Kumawat, P., Prajapati, H., Dave, D., & Prajapat, A. (2025). Formulation and evaluation of medicated gummies. Journal of Pharmacognosy and Phytochemistry, 14(4), 480-485. doi:10.22271/phyto.2025.v14.i4g.15507
- Pawar, M., Rathod, M., & Kale, M. (2025). Formulation and Evaluation of Herbal Weight Gain Gummies. International Journal of Advanced Research in Science Communication and Technology, 235-243. doi:10.48175/ijarsct-26332
- Rashmi, P., & Kejariwal, M. (2023). Formulation of vegan nutritional gummy supplements and their textural-organoleptic analysis. Journal of Applied and Natural Science, 15(4), 1467-1474. doi:10.31018/jans.v15i4.4857
- Raut, S., Nemade, L., & Gavade, A. (2026). Gummy-Based Drug Delivery Systems: A Novel Approach for Oral Formulations. International Journal of Innovative Science and Research Technology (IJISRT), 539-539. doi:10.38124/ijisrt/26jan270
- Andarifera, A., Zaini, E., Yosmar, R., & Fitriani, L. (2025). Formulation and Physical Characterization of Chewable Gummy from Galangal Rhizome Extract (Kaempferia galanga L.) as a Nutraceutical Product. Jurnal Sains Farmasi & Klinis, 12(2), 145-155. doi:10.25077/jsfk.12.2.145-155.2025
- Dey, K., & Sheth, M. (2023). Development of Galactooligosaccharide (GOS) added gummies: sensory, characterization and shelf quality. Food Production Processing and Nutrition, 5(1). doi:10.1186/s43014-022-00117-w
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- G, E., Thirumalaiselvi, K., & Babu, C. (2025). An Analysis of Microbiological Quality and Bioactive Compounds for Preparing Immune Boosting Gummies. Journal of Advances in Microbiology, 25(7), 59-64. doi:10.9734/jamb/2025/v25i7958
- Gaikwad, M. (2025). A Review: Herbal Antitussive Chocolate. International Journal for Research in Applied Science and Engineering Technology, 13(4), 5823-5828. doi:10.22214/ijraset.2025.69004
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- Harshitha, S., Keerthy, H., Zohmingliani, R., Deepak, H., & Prajwal, A. (2025). Development and evaluation of nutrient enriched gummies for pediatric immune support and bone health. Biochemical and Cellular Archives/Biochemical and cellular archives, 25(2), 2049-2060. doi:10.51470/bca.2025.25.2.2049
- Jalalpure, S. (2025). Integrating Traditional Medicine with Modern Drug Delivery Systems: A Path Forward for Holistic Health Care. INDIAN JOURNAL OF AYURVEDA & INTEGRATIVE MEDICINE KLEU, 6(1), 1-3. doi:10.4103/ijaim.ijaim_28_25
- Karande, V., Kale, S., & Pawar, T. (2025). “A critical review of herbal-infused chocolate: health benefits and nutritional value”. International Journal of Pharmaceutical Research and Applications, 10(3), 1126-1141. doi:10.35629/4494-100311261141
- Karole, S., Shrivastava, S., Thomas, S., Soni, B., Khan, S., Dubey, J., . . . Jain, D. (2019). Polyherbal Formulation Concept for Synergic Action: A Review. Journal of Drug Delivery and Therapeutics, 453-466. doi:10.22270/jddt.v9i1-s.2339
- Kean, E., & Adeleke, O. (2023). A child-friendly anti-infective gummy formulation: Design, physicochemical, micromechanical, and taste sensory evaluation. Drug Delivery and Translational Research, 14(5), 1319-1337. doi:10.1007/s13346-023-01464-y
- Khadri, F., K, K., Venkatesh, V., & joshi, H. (2025). Science and Challenges in Formulating Gummies as a Novel Oral Dosage Form: A Review. GSC Biological and Pharmaceutical Sciences, 33(3), 298-307. doi:10.30574/gscbps.2025.33.3.0521
- Khadri, F., Kulkarni, P., Venkatesh, V., & joshi, H. (2025). Science and Challenges in Formulating Gummies as a Novel Oral Dosage Form: A Review. Zenodo (CERN European Organization for Nuclear Research). doi:10.5281/zenodo.18409268
- Khadri, F., Kulkarni, P., Venkatesh, V., & joshi, H. (2025). Science and Challenges in Formulating Gummies as a Novel Oral Dosage Form: A Review. Zenodo (CERN European Organization for Nuclear Research). doi:10.5281/zenodo.18409269
- Khemariya, P., Agrawal, A., & Minnoor, E. (2023). Formulation of Dispersible Ayurvedic Kadha Tablet for the Management of Cold and Cough. Japanese Journal of Medical Research, 1(1). doi:10.33425/2993-6799.1004
- Khune, A., Rathod, H., & Deshmukh, S. (2024). Development of herbal medicated gummies for nicotine cessation support. GSC Biological and Pharmaceutical Sciences, 28(2), 84-89. doi:10.30574/gscbps.2024.28.2.0213
- Kotmire, S., Desai, A., & Chougule, N. (2024). The advances in polyherbal formulation. Journal of Pharmacognosy and Phytochemistry, 210-221. doi:10.22271/phyto.2024.v13.i1c.14828
- Kumari, S., Goyal, A., Gürer, E., Yapar, E., Garg, M., Sood, M., & Sindhu, R. (2022). Bioactive Loaded Novel Nano-Formulations for Targeted Drug Delivery and Their Therapeutic Potential. Pharmaceutics, 14, 1091-1091. doi:10.3390/pharmaceutics14051091
- Kurian, A., George, S., & Thomas, B. (2021). A Review on Phytochemical Characterization of Kwatha–Ayurvedic Polyherbal Formulation. Journal of Natural Remedies, 87-98. doi:10.18311/jnr/2021/25730
- Kurian, P., S, A., R, A., Najimudeen, A., Sajeev, R., & V, S. (2025). Herbal Nutraceutical Gummies: A Comprehensive Review. International Journal of Pharmacy and Pharmaceutical Research, 31(12), 614-623. doi:10.25166/ijppr.2025.31.12.65
- Kyriakoudi, A., Spanidi, E., Mourtzinos, I., & Gardikis, K. (2021). Innovative Delivery Systems Loaded with Plant Bioactive Ingredients: Formulation Approaches and Applications. Plants, 10, 1238-1238. doi:10.3390/plants10061238
- Maurya, D., & Sharma, D. (2020). Evaluation of Traditional Ayurvedic Preparation for Prevention and Management of the Novel Coronavirus (SARS-CoV-2) Using Molecular Docking Approach. ChemRxiv, 104211. doi:10.26434/chemrxiv.12110214
- Oberai, S., Chauhan, R., Mishra, R., Gaur, P., & Singh, R. (2025). Formulation and Evaluation of Herbal Lozenges. Research Journal of Pharmacy and Technology, 4415-4419. doi:10.52711/0974-360x.2025.00633
- Panda, P., & Das, B. (2025). A Comprehensive Review of Ayurvedic Pharmaceutical Dosage Forms: Historical Perspectives and Modern Innovations. Research Journal of Pharmacy and Technology, 1931-1936. doi:10.52711/0974-360x.2025.00276
- Parasuraman, S., Thing, G., & Dhanaraj, S. (2014). Polyherbal formulation: Concept of ayurveda. Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review, 8(16), 73-73. doi:10.4103/0973-7847.134229
- Patel, V., Kumawat, P., Prajapati, H., Dave, D., & Prajapat, A. (2025). Formulation and evaluation of medicated gummies. Journal of Pharmacognosy and Phytochemistry, 14(4), 480-485. doi:10.22271/phyto.2025.v14.i4g.15507
- Pawar, M., Rathod, M., & Kale, M. (2025). Formulation and Evaluation of Herbal Weight Gain Gummies. International Journal of Advanced Research in Science Communication and Technology, 235-243. doi:10.48175/ijarsct-26332
- Rashmi, P., & Kejariwal, M. (2023). Formulation of vegan nutritional gummy supplements and their textural-organoleptic analysis. Journal of Applied and Natural Science, 15(4), 1467-1474. doi:10.31018/jans.v15i4.4857
- Raut, S., Nemade, L., & Gavade, A. (2026). Gummy-Based Drug Delivery Systems: A Novel Approach for Oral Formulations. International Journal of Innovative Science and Research Technology (IJISRT), 539-539. doi:10.38124/ijisrt/26jan270
- Sahare, A., Akare, S., Agrawal, R., Gotephode, S., & Gajbhiye, S. (2025). Standardization and Quality Control of Ayurvedic Polyherbal Formulations. International Journal of Pharmacognosy and Herbal Drug Technology, 103-120. doi:10.64063/3049-1630.vol.2.issue7.9
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- Tanaka, S., Kawamoto, S., Kashiwagura, Y., Hakamata, A., Odagiri, K., Okura, T., . . . Uchida, S. (2023). Improved Palatability of Gummy Drugs of Epinastine Hydrochloride Using Organoleptic Taste-Masking Methods. BPB Reports, 6(6), 184-188. doi:10.1248/bpbreports.6.6_184
- Teixeira?Lemos, E., Almeida, A., Vouga, B., Morais, C., Correia, I., Pereira, P., & Guiné, R. (2021). Development and characterization of healthy gummy jellies containing natural fruits. Open Agriculture, 6(1), 466-478. doi:10.1515/opag-2021-0029
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- Yadav, K., Gawai, N., Shivhare, B., Vijapur, L., & Tiwari, G. (2024). Development and Evaluation of Herbal-Enriched Nutraceutical Gummies for Pediatric Health. Pharmacognosy Research, 16(4), 872-878. doi:10.5530/pres.16.4.99
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