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Abstract

Co-trimoxazole, a combination of sulfamethoxazole and trimethoprim, is a widely used antibiotic with a broad spectrum of activity against various bacterial infections. This abstract provides a concise overview of the basic chemistry, mode of action, and clinical uses of co-trimoxazole. The synergistic action of sulfamethoxazole and trimethoprim targets two consecutive steps in the bacterial folate synthesis pathway. Sulfamethoxazole inhibits dihydropteroate synthetase, a key enzyme in folate synthesis, whereas trimethoprim inhibits dihydrofolate reductase. By disrupting folate synthesis, co-trimoxazole impairs bacterial DNA, RNA, and protein synthesis, leading to bacterial cell death. Co-trimoxazole is employed in the treatment of various bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and gastrointestinal infections. It is particularly effective against bacteria such as Escherichia coli, Staphylococcus aureus, and Haemophilus influenzae. Additionally, co-trimoxazole is used in the prophylaxis and treatment of Pneumocystis jirovecii pneumonia in immunocompromised individuals, such as those with HIV/AIDS

Keywords

Co trimoxazole, Dihydrofolate reductase,Trimethoprim-sulfamethoxazole, bacteria

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Prashant Dattatray waghchaure
Corresponding author

Pratibhatai Pawar college of pharmacy Wadala Mahadev

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Trupti Thange
Co-author

Pratibhatai Pawar college of pharmacy Wadala Mahadev

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Vishal Gaikwad
Co-author

Pratibhatai Pawar college of pharmacy Wadala Mahadev

Prashant Waghchaure , Trupti Thange , Gaikwad Vishal , Basic Chemistry,Mode Of Action And Clinical Uses Of Co-Trimoxazole, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 12, 135-149. https://doi.org/10.5281/zenodo.10300390

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