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Abstract

Tablet coating, an enduring pharmaceutical process, involves the application of a dry outer layer to confer specific benefits on the dosage form, such as taste and odor masking, physical and chemical protection, protects the drug from the gastric surroundings, and control over release profiles. This technique, applicable to various solid oral forms, including particles, powders, granules, crystals, pellets, and tablets, employs a sugar or polymeric coat. Traditional methods, like sugar coating, film coating, and enteric coating, were once prevalent, but recent advancements have circumvented their limitations. Modern coating technologies directly apply materials onto tablet surfaces without solvents, aligning with ICH guidelines advocating the avoidance of organic solvents for pharmaceutical safety. This comprehensive review elucidates the fundamental tablet coating concepts, types of coating, advantages, objective, recent technological strides, challenges encountered in the process, their solutions, and methods for coating evaluation.

Keywords

Tablet Coating, ICH Guidelines, Film Coating, Pharmaceutical Safety, Odor Masking

Reference

  1. Joshi, K. K., & Jain, R. S. (2022). Review article on Enteric coated tablets. Asian Journal of Pharmacy and Technology, 176–178. https://doi.org/10.52711/2231-5713.2022.00029
  2. V, H. (n.d.). A comprehensive review on tablet coating. https://austinpublishinggroup.com/pharmacology-pharmaceutics/fulltext/app-v1-id1001.php
  3. Salawi, A. (2022). Pharmaceutical coating and its different approaches, a review. Polymers, 14(16), 3318. https://doi.org/10.3390/polym14163318
  4. Academy, P. (2022, June 28). TABLET COATING AND ITS DIFFERENT METHODS. PharmaState Academy. https://pharmastate.academy/tablet-coating-and-its-different-methods/
  5. Admin. (2013, April 5). REVIEW: TABLET COATING PROCESS. PharmaTutor. https://www.pharmatutor.org/articles/review-tablet-coating-process
  6. Accela, O. H. M. O. E. (n.d.). Objectives of tablet coating. Ppt Download. https://slideplayer.com/slide/12749483/
  7. Vivek Kumar et al /J. Pharm. Sci. & Res. Vol. 11(6), 2019, 2148-2153
  8. Basu, A. (1970, January 1). Techniques of Tablet Coating: Concepts and Advancements: A Comprehensive review. Open Access Journals. https://www.rroij.com/open-access/techniques-of-tablet-coating-concepts-and-advancements-a-comprehensive-review.php?aid=34923
  9. Nupharma_User. (2021, May 8). Types of coating Equipment Tablet Coating Process - NU Pharma. NU Pharma. https://www.nupharmamachine.com/types-of-coating-equipment-tablet-coating-process/
  10. Pharmapproach. (2023, June 28). Tablet Coating machine. Pharmapproach.com. https://www.pharmapproach.com/tablet-coating-machine/
  11. Sah, A. K. (2014, June 28). Tablet Coating Technology: An Overview. https://ajptonline.com/HTMLPaper.aspx?Journal=Asian Journal of Pharmacy and Technology;PID=2014-4-2-8
  12. Types of tablet coating machines: A complete guide - IPharmachine. (n.d.). https://www.ipharmachine.com/types-of-tablet-coating-machines
  13. Senieer. (2022, September 2). Tablet Coating Machine: Types, advantages, applications, and features. Senieer - What You Trust. https://www.senieer.com/tablet-coating-machine-types-advantages-applications-and-features/
  14. Fig. 5. A top spray fluid bed granulator or coater. (n.d.). ResearchGate. https://www.researchgate.net/figure/A-top-spray-fluid-bed-granulator-or-coater_fig5_240430198
  15. baustill@abstraktmg.com. (2022, October 12). Explaining different types of tablet coating processes | Thomas. Thomas Processing. https://thomasprocessing.com/explaining-different-types-of-tablet-coating-processes/
  16. Limbeck, A., Brunnbauer, L., Lohninger, H., Po?ízka, P., Modlitbová, P., Kaiser, J., Janovszky, P., Kéri, A., & Galbács, G. (2021). Methodology and applications of elemental mapping by laser induced breakdown spectroscopy. Analytica Chimica Acta, 1147, 72–98. https://doi.org/10.1016/j.aca.2020.12.054
  17. Process principles Sugar coating. (n.d.). http://www.cjtech.co.kr/Process Principles Sugar Coating.htm
  18. ThePharmapedia, & ThePharmapedia. (2021, November 24). Sugar Coating of tablets: Pharmaceutics | The Pharmapedia. The Pharmapedia | Your Information, Our Responsibility. https://thepharmapedia.com/sugar-coating-of-tablets-pharmaceutics/pharmacy-notes/
  19. Bhakar, N. (2023a, April 23). 6 Steps Sugar Coating of Tablets: Process, Materials usage, Defects and Remedies. Pharmaguddu. https://pharmaguddu.com/6-steps-sugar-coating-tablets-process-materials-usage-defects-and-remedies/
  20. Ahmed, S. a. N., Patil, S. R., Khan, M. K. S., & Khan, M. S. (2021). Tablet Coating Techniques: concept and recent trends. International Journal of Pharmaceutical Sciences Review and Research, 66(1), 43–53. https://doi.org/10.47583/ijpsrr.2021.v66i01.010
  21. Li, L., Kemp, I., & Palmer, M. (2020). A DEM-based mechanistic model for scale-up of industrial tablet coating processes. Powder Technology, 364, 698–707. https://doi.org/10.1016/j.powtec.2020.01.087
  22. PharmaCentral, Materials and Knowledge Platform. (2021, October 25). Pharmaceutical tablet film coatings. https://pharmacentral.com/learning-hub/technical-guides/pharmaceutical-tablet-film-coating-agents/
  23. Wikipedia contributors. (2023b, September 12). Film coating. Wikipedia. https://en.wikipedia.org/wiki/Film_coating
  24. Film coating. (n.d.). SEPPIC. https://www.seppic.com/en/technologies/film-coating
  25. What are enteric-coated tablets? (n.d.). Drugs.com. https://www.drugs.com/medical-answers/enteric-coated-tablets-3566580/
  26. Wikipedia contributors. (2023c, September 26). Enteric coating. Wikipedia. https://en.wikipedia.org/wiki/Enteric_coating
  27. What is Enteric Coating Process: A Complete Guide - IPharmachine. (n.d.). https://www.ipharmachine.com/enteric-coating-process
  28. Patell, M. K. (1986, February 24). US4775536A - Enteric coated tablet and process for making          - Google Patents. https://patents.google.com/patent/US4775536A/en
  29. Trenfield, S. J., & Basit, A. W. (2020). Modified drug release: Current strategies and novel technologies for oral drug delivery. In Elsevier eBooks (pp. 177–197). https://doi.org/10.1016/b978-0-12-818038-9.00006-5
  30. Team, P., & Team, P. (2023, August 11). Tablet coating defects and remedies. PharmaEducation. https://pharmaeducation.net/tablet-coating-defects/
  31. Sagar, & Savale, S. K. (2023). Pharma-Tablet Coating problems and remedies. ResearchGate. https://www.researchgate.net/publication/373439814_Pharma-Tablet_Coating_Problems_and_Remedies
  32. Rutvik. (2021, November 26). Problems And Remedies For Tablet Coating. Pharmacy Guideline. https://www.pharmacyguideline.com/2021/11/problems-and-remedies-for-tablet-coating.html
  33. Academy, P. (2022a, June 28).  . PharmaState Academy. https://pharmastate.academy/defects-in-coated-tablets/

Photo
Shrikant S. Dongare
Corresponding author

Department of Bachelor in Pharmacy Shivajirao Pawar College of Pharmacy, Pachegaon, Ahmednagar-413725.

Photo
Mr. Dnyaneshwar S. Vyavhare
Co-author

Department of Bachelor in Pharmacy Shivajirao Pawar College of Pharmacy, Pachegaon, Ahmednagar-413725.

Photo
Dr. Megha T. Salve
Co-author

Department of Bachelor in Pharmacy Shivajirao Pawar College of Pharmacy, Pachegaon, Ahmednagar-413725.

Shrikant S. Dongare*, Mr. Dnyaneshwar S. Vyavhare, Dr. Megha T. Salve, Concept And Recent Advancement In Tablet Coating Technologies: A Comprehensive Review, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 496-506. https://doi.org/10.5281/zenodo.10207162

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