Archive

Abstract

Tablets of the drug diclofenac sodium with an enteric coating are used to treat fever, discomfort, and inflammation. The pills are made to withstand the stomach's acidic environment while dissolving in the small intestine's alkaline environment. With this delayed release formulation, there is a lower chance of experiencing gastrointestinal adverse effects while also extending the duration of medication absorption and increasing medicinal efficacy. Enteric coated tablets are solid unit dose forms for oral administration that bypass the stomach and transport the medication straight to the small intestine. Given that the name "enteric" refers to the small intestine, enteric coatings prevent the release of medication before it reaches this organ. A coated surface that is stable at the stomach's very acidic pH is how most enteric coatings work.

Keywords

Diclofenac sodium, tablets, nonsteroidal anti-inflammatory medication

Reference

  1. Langner M, Kozubek A. Pharmacokinetic modulation with particulate drug formulations. Nanocarrier Technologies: Frontiers of Nanotherapy. 2006:113-38.
  2. Carlson TJ, Fisher MB. Recent advances in high throughput screening for ADME properties. Combinatorial chemistry & high throughput screening. 2008 Mar 1;11(3):258-64.
  3. Bernardo PH, Tong JC. In silico design of small molecules. Chemical Genomics and Proteomics: Reviews and Protocols. 2012:25-31.
  4. Kodadek T. The rise, fall and reinvention of combinatorial chemistry. Chemical communications. 2011;47(35):9757-63.
  5. Jones HM, Mayawala K, Poulin P. Dose selection based on physiologically based pharmacokinetic (PBPK) approaches. The AAPS journal. 2013 Apr;15(2):377-87.
  6. Brater DC. Anti-inflammatory agents and renal function. InSeminars in arthritis and rheumatism 2002 Dec 1 (Vol. 32, No. 3, pp. 33-42). WB Saunders.
  7. Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA, Bombardier C, Cannon C, Farkouh ME, FitzGerald GA, Goss P. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet (London, England). 2013 May 30;382(9894):769-79.
  8. Kuo HW, Tsai SS, Tiao MM, Liu YC, Lee IM, Yang CY. Analgesic use and the risk for progression of chronic kidney disease. Pharmacoepidemiology and drug safety. 2010 Jul;19(7):745-51.
  9. Lewis SC, Langman MJ, Laporte JR, Matthews JN, Rawlins MD, Wiholm BE. Dose–response relationships between individual nonaspirin nonsteroidal anti?inflammatory drugs (NANSAIDs) and serious upper gastrointestinal bleeding: a meta?analysis based on individual patient data. British journal of clinical pharmacology. 2002 Sep;54(3):320-6.
  10. Castellsague J, Riera-Guardia N, Calingaert B, Varas-Lorenzo C, Fourrier-Reglat A, Nicotra F, Sturkenboom M, Perez-Gutthann S, Safety of Non-Steroidal Anti-Inflammatory Drugs (SOS) Project. Individual NSAIDs and upper gastrointestinal complications: a systematic review and meta-analysis of observational studies (the SOS project). Drug safety. 2012 Dec;35:1127-46.
  11. Salvo F, Fourrier?Réglat A, Bazin F, Robinson P, Riera?Guardia N, Haag M, Caputi AP, Moore N, Sturkenboom MC, Pariente A, investigators of the Safety of Non?Steroidal Anti?Inflammatory Drugs: The SOS Project. Cardiovascular and gastrointestinal safety of NSAIDs: a systematic review of meta?analyses of randomized clinical trials. Clinical Pharmacology & Therapeutics. 2011 Jun;89(6):855-66.
  12. Salvo F, Fourrier?Réglat A, Bazin F, Robinson P, Riera?Guardia N, Haag M, Caputi AP, Moore N, Sturkenboom MC, Pariente A, investigators of the Safety of Non?Steroidal Anti?Inflammatory Drugs: The SOS Project. Cardiovascular and gastrointestinal safety of NSAIDs: a systematic review of meta?analyses of randomized clinical trials. Clinical Pharmacology & Therapeutics. 2011 Jun;89(6):855-66.
  13. McGettigan P, Henry D. Cardiovascular risk with non-steroidal anti-inflammatory drugs: systematic review of population-based controlled observational studies. PLoS medicine. 2011 Sep 27;8(9):e1001098.
  14. Altman R, Bosch B, Brune K, Patrignani P, Young C. Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology. Drugs. 2015 May;75:859-77.
  15. Moreno MM, Garidel P, Suwalsky M, Howe J, Brandenburg K. The membrane-activity of Ibuprofen, Diclofenac, and Naproxen: A physico-chemical study with lecithin phospholipids. Biochimica et Biophysica Acta (BBA)-Biomembranes. 2009 Jun 1;1788(6):1296-303.
  16.  Rao P, Knaus EE. Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond. Journal of pharmacy & pharmaceutical sciences. 2008 Sep 20;11(2):81s-110s.
  17. Maclagan T. The treatment of rheumatism by salicin and salicylic acid. British medical journal. 1876 May 5;1(803):627.
  18. Stricker S. Über die Resultate der Behandlung der Polyarthritis rheumatica mit Salicylsäure. Berl Klin Wochenschr. 1876;13:1-2.
  19.  Sneader W. The discovery of aspirin: a reappraisal. BMJ. 2000;321(7276):1591–4.
  20.  Brune K, Hinz B. The discovery and development of antiinflammatory drugs. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology. 2004 Aug;50(8):2391-9.
  21. . Domenjoz R. The pharmacology of phenylbutazone analogues. Annals of the New York Academy of Sciences. 1960 Mar;86(1):263-91.
  22. Madhusudan Rao Y, Veni JK, Jayasagar G. Formulation and evaluation of diclofenac sodium using hydrophilic matrices. Drug development and industrial pharmacy. 2001 Jan 1;27(8):759-66.
  23. Badwaik H, Tripathi DK. In vitro evaluation of commercially available enteric coated tablet containing diclofenac sodium. inflammation. 2012;2:3.
  24. Chhater S, Rajesh K, Kshitij A, Nema RK. Development and evaluation of enteric coated tablet containing diclofenac sodium. International journal of pharmaceutical sciences and nanotechnology. 2009;2:443-9.
  25. Badwaik H, Tripathi DK. In vitro evaluation of commercially available enteric coated tablet containing diclofenac sodium. inflammation. 2012;2:3..
  26.  Pharmacopoeia I. Controller of publications. New Delhi. 1996;2:764.
  27.  Zaid AN, Qaddomi A. Development and stability evaluation of enteric coated Diclofenac sodium tablets using Sureteric. Pakistan journal of pharmaceutical sciences. 2012 Jan 1;25(1).
  28. Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020;6(2):94-100.

image
Gyanesh Kumar Sahu
Corresponding author

Rungta Institute of Pharmaceutical Sciences and Research

image
Jatin Kumar Sinha
Co-author

Rungta Institute of Pharmaceutical Sciences

image
Bhumika Sahu
Co-author

Rungta Institute of Pharmaceutical Sciences

image
Harish Sharma
Co-author

Rungta Institute of Pharmaceutical Sciences

image
Jatin Kumar Sinha
Co-author

Rungta Institute of Pharmaceutical Sciences

Jitendra Sahu, Jatin Kumar Sinha, Bhumika Sahu, Harish Sharma, Gyanesh Kumar Sahu, Development and Characterization of Enteric Coated Diclofenac Sodium Tablet, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 4, 210-218. https://doi.org/10.5281/zenodo.7921095

More related articles
Hepatoprotective Role of Flavonoids from Ocimum Sa...
Suddagoni Santhosh, Narsapuram Bharathi, Thalla Likesh Goud, Guni...
Formulation and Evaluation of Antifungal and Muscl...
Chetan S. Darne, Monika P. Maske, Pawan A. Gore, Jagdish R. Bahet...
A Study on OTC products in India and Europe: Marke...
Dheeraj Kotagiri, Dr. Bhavana B Bhat, Venkateswara Raju, K. Krish...
Classification Of Different Antibiotics And Their Adverse Effects And Uses From ...
A. L.T. Kalyani, M.S.V. maha Lakshmi , N.Ahalya , P.Anusha, SD.Seema, T.Maneesha, ...
Formulation And Evaluation Of Herbal Anti-Bacterial Crack Heel Ointment Using Th...
Ms.Priyanka Raut, Mrs.Manisha Mishra, Gayatri Bawane, Ayushi Ambade, Alshapha Anjum Khan, Abhilasha ...
Ozone And Ozonated Oils In Skin Diseases...
Salunke R. Yashraj, Saurabh R. Kharat , Sham Ganesh Ardad , Nimbalkar Vaibhav , Jadhav Anil B. , ...
Related Articles
Formulation And Evaluation of Sustained Release Matrix Tablets A Review...
Muni Raja Lakshmi K, Naseema Shaik, Lavanya E, Venkata Rao Gadde, ...
Anti Ulcer Activity Of Medicinal Plants ...
Gauri S Salunke , Gayatri B Gaware , Rupali N Tarde , Payal A Pangude , Sayyed Afnan kirmani, ...
Lifestyle Medicine Encompassing Scientific Exercises and Right Diet The Key To P...
J.C Balachandar, S. Irshad Ahamed, Amit Kumar Agrawal, Baani Khanna, Dilsher Khanna, M. Jayachandran...
Hepatoprotective Role of Flavonoids from Ocimum Sanctum Against Halothane Induce...
Suddagoni Santhosh, Narsapuram Bharathi, Thalla Likesh Goud, Gunisetti Sri Anjali, Pitla Maheshwari,...
More related articles
Hepatoprotective Role of Flavonoids from Ocimum Sanctum Against Halothane Induce...
Suddagoni Santhosh, Narsapuram Bharathi, Thalla Likesh Goud, Gunisetti Sri Anjali, Pitla Maheshwari,...
Formulation and Evaluation of Antifungal and Muscle Relaxant Herbal Bath Bomb Co...
Chetan S. Darne, Monika P. Maske, Pawan A. Gore, Jagdish R. Baheti, ...
A Study on OTC products in India and Europe: Market Prospective...
Dheeraj Kotagiri, Dr. Bhavana B Bhat, Venkateswara Raju, K. Krishna Teja, K. Jnanendra Kumar, M. Jee...
Hepatoprotective Role of Flavonoids from Ocimum Sanctum Against Halothane Induce...
Suddagoni Santhosh, Narsapuram Bharathi, Thalla Likesh Goud, Gunisetti Sri Anjali, Pitla Maheshwari,...
Formulation and Evaluation of Antifungal and Muscle Relaxant Herbal Bath Bomb Co...
Chetan S. Darne, Monika P. Maske, Pawan A. Gore, Jagdish R. Baheti, ...
A Study on OTC products in India and Europe: Market Prospective...
Dheeraj Kotagiri, Dr. Bhavana B Bhat, Venkateswara Raju, K. Krishna Teja, K. Jnanendra Kumar, M. Jee...