Archive

Abstract

Oral intake of Itraconazole (ITZ) causes severe side effects in the gastrointestinal tract and has low bioavailability ~55%. Owing to these disadvantages, Transdermal drug delivery system (TDDS) of such antifungal agents can overcome such issues and can improve the efficacy and bioavailability. The aim of this study was to evaluate the potential of proniosomes as a transdermal drug delivery system for ITZ by encapsulating the drug in various formulations of proniosomal gel by Coacervation-phase separation method. Among all the formulated proniosomal gel formulation TF5 containing tween 20 was found to be the most appropriate surfactant and was selected for preparing Transdermal proniosomal hydrogel which was formulated using different concentrations of Carbopol and HPMC. These gels were characterized for pH, spreadability, drug content and in-vitro diffusion study and stability studies wherein the optimized formulation (G2) showed the values of 7.01, 33.70 g.cm/sec, 99.5% and 87.83% (p<0.05). The drug release kinetics studies revealed that release was prolonged up to 8hrs and release pattern was found to be diffusion controlled which was confirmed by Higuchi’s plot. The results of this study suggest that proniosomes are promising nano vesicular carriers to enhance the transdermal delivery of ITZ.

Keywords

Itraconazole, antifungal, proniosomes, transdermal drug delivery, hydrogel, in-vitro release, antifungal activity, skin irritation study

Reference

  1. Raymond C Rowe R, Paul J Sheskey P, Marian E Quinn M. Handbook of Pharmaceutical Excipients. 6th ed. London: The Pharmaceutical Press; 2009: 596- 97
  2. Li Q, Li Z, Zeng W, Shumin G, Lu H. Proniosome-Derived Niosomes for Tacrolimus Topical Ocular Delivery: In-Vitro Cornea Permeation, Ocular Irritation, and In-Vivo Anti-Allograft Rejection. Eur. J. Pharm. Sci. 2014; 62(1): 115-23.
  3. Ammar H, Ghorab M, Nahhas S, Higazy I. Proniosomes as a Carrier System for Transdermal Delivery of Tenoxicam. Int. J. Pharm. 2011;405: 142-52.
  4. Ramkanth S, Chetty C, Sudhakar Y, Thiruvengadarajan V, Anitha P et al. Development, Characterization & In-Vivo Evaluation of Proniosomal Based Transdermal Delivery System of Atenolol. Future. J Pharm. Sci. 2018; 4: 80-87.
  5. Gouda R, Baishya H, Qing Z. Application of Mathematical Models in Drug Release Kinetics of Carbidopa and Levodopa ER Tablets. Journal of Developing Drugs. 2017;6(2): 1-8.
  6. Nimbalwar M, Upadhye K, Dixit G. Fabrication and Evaluation of Ritonavir Proniosomal Transdermal Gel as a Vesicular Drug Delivery System. Pharmacophore. 2016; 7(2): 82-95.
  7. Priyanka H, Bhaskar V, Priya P, Shankar R. Formulation and Evaluation of Carvedilol Proniosomal Gel. Int. J. Pharm. Pharm Res. 2015; 4 (1): 190-02.
  8. Khudair N, Agouni A, Elrayess M, Najlah M, Younes M et al. Letrozole-loaded Nonionic Surfactant Vesicles Prepared Via a Slurry-Based Proniosome Technology: Formulation Development and Characterization. J. Drug Del Sci Technol. 2020; 58:101721.
  9. Patil H, Hardikar S, Bhosale A. Formulation Development & Evaluation of Proniosomal Gel of Carvedilol. Int. J. Pharm. Pharm Res. 2012;4(1): 191-97.
  10. Alkilani A, Mccrudden M, Donnelly R. Transdermal drug delivery: Innovative Pharmaceutical development Based on Disruption of the Barrier Properties of the Stratum Corneum. Pharmaceutics. 2015; 7: 438-70.
  11. Patel D, Chaudhary S, Parmar B, Bhura N. Transdermal Drug Delivery System: A Review.  The Pharma Innovation. 2012; 1(4): 66-75.
  12. Sharma N, Agarwal G, Rana A, Bhat Z, Kumar O. A Review: Transdermal Drug Delivery System: A Tool for Novel Drug Delivery System. International Journal of Drug development and Research 2011; 3(3): 70-84.

image
Akshata Rajesh Shirodker
Corresponding author

Department of Pharmaceutics, Goa College of Pharmacy, Panaji- 403001, Goa, India.

image
Rajashree Gude
Co-author

Department of Pharmaceutics, Goa College of Pharmacy, Panaji- 403001, Goa, India.

image
Suman Harisingh Vishwakarma
Co-author

Department of Pharmaceutics, Goa College of Pharmacy, Panaji- 403001, Goa, India.

image
Eliska Wendy de Souza
Co-author

Department of Pharmaceutics, Goa College of Pharmacy, Panaji- 403001, Goa, India.

image
Vishakha Hari Naik
Co-author

Department of Pharmaceutics, Goa College of Pharmacy, Panaji- 403001, Goa, India.

image
Shubhrata Shyam Gawas
Co-author

Department of Pharmaceutics, Goa College of Pharmacy, Panaji- 403001, Goa, India.

Rajashree Gude, Suman Harisingh Vishwakarma, Akshata Rajesh Shirodker*, Eliska Wendy de Souza, Vishakha Hari Naik, Shubhrata Shyam Gawas, Formulation And Characterization Of Provesicular Based Drug Delivery System For Effective Transdermal Delivery Of Antifungal Drug, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 331-346. https://doi.org/10.5281/zenodo.8348393

More related articles
AI Powered Virtual Health Assistants: Transforming...
Durga P. Chavali, Vinod Kumar Dhiman, Siri Chandana Katari, ...
A Comparative Study of Ketorolac, Paracetamol and ...
Syed Jaffer, Shaista Sumayya, Meraj fatima, Safa mehboobunnisa si...
Artificial Intelligence in Predicting Drug Target ...
Ishu Garg, Harish, Mohit Kumar, Vishvanshi Tyagi, ...
A study of challenges and quality of life QoL issues related to Vitiligo disease...
Yash Srivastav, Akhandnath Prajapati, Adityanath Prajapati, Madhaw Kumar, Mohammad Aqil Siddiqui, ...
Male And Female Infertility Which Cause Child Birth Problem...
Koshish Gabhane, Aman S. Maharaj, Ankita S. Kadu, Siya V. Chawan, Suyog R. Ambadkar, ...
Niosomes: An Innovative Tailored Cancer Medication Delivery Mechanism...
Shivani S. C. Gupta, Punam K. Satav, Kalyani K. Malthane, Vaibhav S. Adhao, Jaya P. Ambhore, Jaya P....
Related Articles
Thin Layer Chromatographic And UV Spectrophotometric Analysis Of Frequently Util...
Samuel J. Bunu, Veronica Aniako, Varsharani P. Karade, Edebi N. Vaikosen, Benjamin U. Ebeshi, ...
Preliminary Phytochemical Screening, Photoluminance Study And TLC Of Leaf Extrac...
Nikhil Rana, Chinu Kumari, Dev Prakash Dahiya, Rahul Sharma, ...
AI Powered Virtual Health Assistants: Transforming Patient Engagement Through Vi...
Durga P. Chavali, Vinod Kumar Dhiman, Siri Chandana Katari, ...
More related articles
AI Powered Virtual Health Assistants: Transforming Patient Engagement Through Vi...
Durga P. Chavali, Vinod Kumar Dhiman, Siri Chandana Katari, ...
A Comparative Study of Ketorolac, Paracetamol and Tramadol for Post Operative Pa...
Syed Jaffer, Shaista Sumayya, Meraj fatima, Safa mehboobunnisa siddiqi, Ruqshan Nazneen, ...
Artificial Intelligence in Predicting Drug Target Proteins : A Review...
Ishu Garg, Harish, Mohit Kumar, Vishvanshi Tyagi, ...
AI Powered Virtual Health Assistants: Transforming Patient Engagement Through Vi...
Durga P. Chavali, Vinod Kumar Dhiman, Siri Chandana Katari, ...
A Comparative Study of Ketorolac, Paracetamol and Tramadol for Post Operative Pa...
Syed Jaffer, Shaista Sumayya, Meraj fatima, Safa mehboobunnisa siddiqi, Ruqshan Nazneen, ...
Artificial Intelligence in Predicting Drug Target Proteins : A Review...
Ishu Garg, Harish, Mohit Kumar, Vishvanshi Tyagi, ...