KIET Group of Institutions, Delhi-NCR, Ghaziabad
Acne-vulgaris are a common inflammatory and non-inflammatory disease that is caused by Propionibacterium acne and can occur at any age. Now a days many therapies are used for the treatment of acne such as systemic, topical, herbal, hormonal, and combination therapies. To treat the acute to chronic acne lotion containing azelaic acid is formulated. Azelaic acid belongs to the class of drugs congaing di-carboxylic acids, which is characterized by antibacterial, anti-keratinizing, and anti comedogenic effects on acne. The anti-acne azelaic acid drug exhibits often very low solubility and low permeability. Hence topical preparation of azelaic acid shows difficulties due to its low permeability and solubility. Drugs in suitable dosage form and optimum concentration provide the better penetration and anti-acne effect. In the acne treatment line anti-acne azelaic acid lotion is a novel formulation. Its novelty lies in the lotion contain mostly water and very little oil. Azelaic acid cream contains 50% oil and 50% water, due to this reason lotion have a much thinner consistency compared to cream-based products. This means lotions are ideal for oily skin when compare to creams. This formulation absorbs easily into the skin without any topical residue. For optimum penetration of azelaic acid this formulation is carefully formulated by selective excipients that help to absorb excessive oil from the skin without touching the natural oil balance.
Deepak Kumar, Dr. M.A. Sheela, Formulation And Optimization Of Anti-Acne Lotions Containing Azelaic Acid For The Use Of A Topical Applications, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 10, 205-209. https://doi.org/10.5281/zenodo.10031154