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Abstract

A 76-year-old man who had sigmoid colon cancer underwent a colectomy. As adjuvant therapy, the patient was prescribed capecitabine (2g tablets)for two weeks followed by a week off. After completing four complete treatment cycles, the patient developed lacrimation and irritation of the eyes in addition to hand and foot discoloration. It is important to identify such adverse drug reactions and report them.

Keywords

Capecitabine,5-fluorouracil, Colorectal cancer, Hyperpigmentation.

Reference

  1. Caprez, J., Rahim, U., Ansari, A., Lodhi, M. U., & Rahim, M. (2018). Hyperpigmentation with Capecitabine: Part of Hand-Foot Syndrome or a Separate Entity? Cureus. https://doi.org/10.7759/cureus.2397
  2. Kwakman, J. J., Elshot, Y. S., Punt, C. J., & Koopman, M. (2020). Management of cytotoxic chemotherapy-induced hand-foot syndrome. Oncology Reviews, 14(1). https://doi.org/10.4081/oncol.2020.442
  3. Chen, M., Chen, J., Peng, X., Xu, Z., Shao, J., Zhu, Y., Li, G., Zhu, H., Yang, B., Luo, P., & He, Q. (2017). The contribution of keratinocytes in capecitabine-stimulated hand-foot-syndrome. Environmental Toxicology and Pharmacology, 49, 81–88. https://doi.org/10.1016/j.etap.2016.12.001
  4. de Queiroz MVR, de Medeiros ACTR, Toledo SP, de Abreu Sarmenghi KD, de Vasconcellos VF. Hand-foot syndrome caused by capecitabine: incidence, risk factors and the role of dermatological evaluation. Ecancermedicalscience. 2022 May 16;16:1390. doi: 10.3332/ecancer.2022.1390. PMID: 35919225; PMCID: PMC9300399.
  5. Nagore E, Insa A, Sanmartín O. Antineoplastic therapy-induced palmar plantar erythrodysesthesia ('hand-foot') syndrome. Incidence, recognition and management. Am J Clin Dermatol. 2000;1:225–34.
  6. Lee, S., Kim, H., Hwang, S., Kim, Y. J., Nam, S., & Kim, B. (2007). Hand-Foot Syndrome with Scleroderma-like Change Induced by the Oral Capecitabine: A Case Report. Korean Journal of Internal Medicine, 22(2), 109. https://doi.org/10.3904/kjim.2007.22.2.109
  7. Kataria, P., Kendre, P., Patel, A., Tahiliani, N., Bhargav, V., & Parekh, H. (2018). Rare occurrence of hand-foot syndrome due to paclitaxel: A rare case report. Indian Journal of Pharmacology. https://doi.org/10.4103/ijp.ijp_547_17
  8. Saif MW, Sandoval A. Hand-and-Foot syndrome in an African American Patient treated with Capecitabine with normal DPD activity: Is there an ethnic disparity? Cutan Ocul Toxicol. 2008;27:311–5. [PubMed] [Google Scholar] [Ref list]

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Asra Jabeen
Corresponding author

Department of Pharmacology Government Medical Collage and Associated Hospital , Anantnag ,Jammu &Kashmir, India

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Masrat Nabi
Co-author

Department of Pharmacology Government Medical Collage and Associated Hospital , Anantnag ,Jammu &Kashmir, India

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Sheikh H. Ismail
Co-author

Department of Pharmacology Government Medical Collage and Associated Hospital , Anantnag ,Jammu &Kashmir, India

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Zahid Akhtar
Co-author

Department of Pharmacology Government Medical Collage and Associated Hospital , Anantnag ,Jammu &Kashmir, India

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Sami Magray
Co-author

Department of Pharmacology Government Medical Collage and Associated Hospital , Anantnag ,Jammu &Kashmir, India

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Nasreen Chashoo
Co-author

Department of Pharmacology Government Medical Collage and Associated Hospital , Anantnag ,Jammu &Kashmir, India

Asra Jabeen ,Masrat Nabi ,Sheikh H. Ismail, Nasreen Chashoo, Sami Magray, Zahid Akhtar, Hand And Foot Syndrome With Hyperpigmentation By Capecitabine, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 233-236. https://doi.org/10.5281/zenodo.10643205

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