UV Method Of Development For Estimation Of Losartan In Bulk & Marketed Formulation

Table 6.1: List of chemicals
       
           
       
Table 6.2: List of Equipment
       
           
       
    FORMULATION

Validation of UV Method

Linearity and Range

       
           
       
   Linearity curve for Losartan

Precision

CONCLUSION

The simple spectrophotometric method for determination of Losartan has been developed and validated as per ICH guidelines. The developed method is found to be sensitive, accurate and reproducible and can be used for the routine quality control analysis of Losartan in bulk and pharmaceutical formulations. Attempts were made to develop spectrophotometric for estimation of Losartan. The spectrophotometric methods were developed for estimation. For the spectrophotometric methods, Methanol was used as solvent. The wavelength used for Losartan 208nm. The spectrophotometric methods were validated according to the ICH guidelines. The linearity, precisions, LOD, LOQ by the spectrophotometric method were within the limit as specified by the ICH guidelines. Hence the methods were found to be simple, accurate, precise, economic and reproducible. so the proposed methods can be used for the routine quality control analysis of Venlafaxine in bulk drug as well as in formulations.

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