View Article

Abstract

Atenolol is an Synthetic Beta-1 selective blocker, primarily used in management of hypertension and Chronic angina and to reduce mortality in known or suspected myocardial infarction. It belongs to BCS class III having a half-life of 7hrs and 50% bioavailability. The purpose of the present work was to design and optimize compression coated floating pulsatile drug delivery systems of Atenolol as an antihypertensive agent. The prepared system was composed of two components: an active ingredient-containing core tablet and an erodible outer shell with a gas-producing agent. The active component was combined with super disintegrates to create the rapid release core tablet (RRCT). By using polymer, the optimized RRCT was press coated. The optimization procedure made use of a 32 complete factorial design. As independent variables, Avicel pH 102 and the quantity of HPMC K200M were used. Lag time and hardness were selected as dependent variables. Floating pulsatile release formulation (FPRT) F8 at level +1 (100mg) for HPMC K200M and level -1 (20mg) for Avicel pH 102 showed lag time of 6 h with >90% drug release. The values of n were more than 1.

Keywords

Floating, Press-coated, Core tablet, HPMC K-200, Pulsatile, Delivery

Reference

  1. Lachmann L, Lieberman HA, Kanig JL.  The Theory & Practice of Industrial Pharmacy, 3rd Edition, Varghese Publishing House, Bombay 1991: 430.
  2. Robinson JR, Lee HL (Ed).  Controlled Drug Delivery: Fundamentals & Applications. 2nd Edition, Marcel Dekker Inc., New York, 1987; 373.
  3. Gennaro AR (Ed.) Remington.  The Science & Practice of Pharmacy.  19th Edition, Vol. II; 1995: 1662.
  4. Shargel L and Andrew BC. Applied Biopharmaceutics and Pharmacokinetics (4th Edn.), 174.
  5. Remingtons; The science & practice of pharmacy, 20th Edn., Lippan cott, Williams & Wilkins, Baltimore, Marryland, 1995; 721-752.
  6. Martindale, The Complete Drug Reference, 33rd Edn, The Pharmaceutical Press, London, 2001: 332-33.
  7. Qiu. Y et al., Formulation development of sustained release hydrophilic matrix tablets of zileuton, Pharmaceutical Development and Technology, 2 (3): 197-204, 1997.
  8. Xu. G and Sunada. H., Influence of formulation change on drug release kinetics from hydroxypropyl methyl cellulose matrix tablets, Chem.Pharm.Bull., 43 (mar): 483-487, 1995.
  9. USP; The United States Pharmacopial Convention Inc., CD-2004; USP 27-NF-22.
  10. Lachmann L, Lieberman HA, Kanig JL.  The Theory & Practice of Industrial Pharmacy, 3rd Edn, Varghese Publishing House, Bombay 1991: 430.
  11. Higuchi.T., Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices, J. Pharm. Sci., 51: 1145-1149, 1963.
  12. Korsmeyer, R. W., Gurny. R.,  Doelker. E., Buri. P.,  Peppas. N.A., Mechanism of solute release from porous hydrophilic polymer, Int. J. Pharm, 15: 25-35, 1983.

Photo
Mansuri Toshib
Corresponding author

Department Of Pharmaceutics, Ali-Allana College of Pharmacy, Akkalkuwa, Nandurbar, Maharashtra, India.

Photo
Adnan Siddiqui
Co-author

Department Of Pharmaceutics, Ali-Allana College of Pharmacy, Akkalkuwa, Nandurbar, Maharashtra, India.

Photo
Sk Shehzad
Co-author

Department Of Pharmaceutics, Ali-Allana College of Pharmacy, Akkalkuwa, Nandurbar, Maharashtra, India.

Photo
Sohel Khan
Co-author

Department Of Pharmaceutics, Ali-Allana College of Pharmacy, Akkalkuwa, Nandurbar, Maharashtra, India.

Photo
Mayur Gokul Jayswal
Co-author

Department Of Pharmaceutics, Ali-Allana College of Pharmacy, Akkalkuwa, Nandurbar, Maharashtra, India.

Photo
Bagwan Wasim
Co-author

Department Of Pharmaceutics, Ali-Allana College of Pharmacy, Akkalkuwa, Nandurbar, Maharashtra, India.

Photo
Dr. Rehan Deshmukh
Co-author

Guide, Department Of Pharmaceutics, Ali-Allana College of Pharmacy, Akkalkuwa, Nandurbar, Maharashtra, India.

Mansuri Toshib*, Adnan Siddiqui, Sk Shehzad, Sohel Khan, Mayur Gokul Jayswal, Bagwan Wasim, Dr. Rehan Deshmukh, Development And Evaluation Of Pressed Coated Floting Pulsatile Tablet Of Atenolol, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 10, 13-21. https://doi.org/10.5281/zenodo.8396445

More related articles
Applications Of Gold Nanoparticles In Treating Dia...
Sachin J. Kamble, Valmiki B. Koli, ...
A REVIEW OF ARTIFICIAL BLOOD...
Harshal Bhagat, Shivanand Morde, Mansi Shinde , Akshada Pawar, Am...
Formulation And Evaluation Of Herbal Hair Oil ...
Sohel Shaikh, Tejashri Kedar , Abubakar Shaikh , Aman Shaikh, Dev...
Revolutionizing Herbal Therapeutics: Exploring Advanced Nanotechnology Drug Deli...
Ankita. S. Kshirsagar, Tushar Rode, Ishwari. R. Chaudhari, Anil. V. Chandewar, ...
Formulation And Optimization Of Microemulsions For Improved Amlodipine Besylate ...
Mahadeo khose, Thakursing Dinesh Pawar , Dr. Nilesh Jadhav, Sugriv Ghodake, Gajanan Patingrao, Kiran...
Targeting Glutamate Signalling in Anxiety Disorders: Novel Insights and Therapeu...
Arnab Roy, Prof. (Dr.) K. Rajeswar Dutt , Ankita Singh, Mahesh Kumar Yadav, Kristy Kumari , Vishal K...
Related Articles
Insilico Screening Of Novel Pyrimidinones As Potential Her2 Inhibitors Targeting...
A Nazrin Fathima, A Sumathy, S Greeshma, N L Gowrishankar, ...
Assessing Medication Appropriateness: A Prospective Observational Study At A Ter...
Chethan Prabhu, Krishnananda Kamath K, Ramakrishna Shabaraya, ...
Polymers Used In Floating Drugs Delivery System-A Review ...
Ram prasad khoteja, Aarti Kori , Shivanand Patil , ...
Role Of Ginger And Its Constituents In Prevention And Treatment Of Colon Cancer...
Swapnil G. Vilhekar, Pooja M. Athawale, Dr. Jagdish V. Manwar, ...
More related articles
A REVIEW OF ARTIFICIAL BLOOD...
Harshal Bhagat, Shivanand Morde, Mansi Shinde , Akshada Pawar, Amol Nathe, ...
Formulation And Evaluation Of Herbal Hair Oil ...
Sohel Shaikh, Tejashri Kedar , Abubakar Shaikh , Aman Shaikh, Devang Shah, Harsh Meher , ...
A REVIEW OF ARTIFICIAL BLOOD...
Harshal Bhagat, Shivanand Morde, Mansi Shinde , Akshada Pawar, Amol Nathe, ...
Formulation And Evaluation Of Herbal Hair Oil ...
Sohel Shaikh, Tejashri Kedar , Abubakar Shaikh , Aman Shaikh, Devang Shah, Harsh Meher , ...