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Abstract

Costus Igneus known as Insulin plant is one such traditional plant which is getting global acceptance and is now widely used as an ayurvedic medicinal herb.The present study investigates the Antimitotic activity of the plant leaves. The leaves of plant were collected, and the aqueous and ethanolic extracts were prepared using soxhlet apparatus. These extracts were tested for phytochemicals and showed the presence of alkaloids and flavonoids, anthraquinones, taninns, phenolic compounds, terpenoids, saponins and proteins and absences of carbohydrates. The Antimitotic activity of ethanolic extract and aqueous extract of costus igneus leaves were evaluated using Seed germination method. The costus igneus leaves extracts is capable of inhibiting the germination of green gram seeds as result indicates 55.3% and 63.5% inhibition by ethanolic extract at 5mg/ml and 10mg/ml respectively whereas aqueous extract showed 69.4% and 70.5% inhibition at 5mg/ml and 10mg/ml when compared with the percentage inhibition of standard paclitaxel which showed 96.6% inhibition indicates that the ethanolic and aqueous extract of costus igneus is having antimitotic activity. Hence this indicates that plant leaves having alkaloids and flavonoids and absence of carbohydrates show antimitotic activity. The aqueous extract of costus igneus leaves showed more potent antimitotic activity when compare to the ethanolic extract.Further studies can be carried out to determine the most effective chemical compound responsible for anti mitotic activity in this plant to treat different stages of cancer.

Keywords

Mitosis, Antimitotic, Phytochemicals, Costeus igneus, Paclitaxel

Reference

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Preethi Chavan
Corresponding author

Department of Pharmacology, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad.

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Amtul H Gazala
Co-author

Department of Pharmacology, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad.

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Juwaria Begum
Co-author

Department of Pharmacology, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad.

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Sadiyah Sultana
Co-author

Department of Pharmacology, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad.

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Syeda M Noorain
Co-author

Department of Pharmacology, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad.

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Tashveen Begum
Co-author

Department of Pharmacology, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad.

Preethi Chavan*, Amtul H Gazala, Juwaria Begum, Sadiyah Sultana, Syeda M Noorain, Tashveen Begum, Evaluation Of Antimitotic Activity of Phytochemicals Present In Extracts Of Costus Igneus Leaves, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 8, 165-178. https://doi.org/10.5281/zenodo.8250792

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