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Abstract

The drug action can be improved by developing the new drug delivery system, such as the mucoadhesive drug delivery system. These systems remain in close contact with absorption tissue the mucus membrane, releasing the drug action site leading to a bioavailability rise and both local and systemic effect . The mucoadhesion is currently explained by 5 theories: Wetting, Electrostatic, Diffusion, Adsorption, Fracture. The polymers used for the formulation of mucoadhesive drug delivery system are PAA (polyacrylamide acid),chitosan, collagen, gelatin and newer second-generation polymers. The process of complex one that includes process such as wetting, adsorption and interpretation of polymer chain. The mucoadhesive ability of a dosage form is depend upon the variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. Mucoadhesive system have found wide use throughout many mucosal covered organelles for active ingredients delivery for local or systemic effect. The administration of the drug by the buccal route has several advantages over per oral administration such as quick action improved the patient compliance particularly with the paediatrics and geriatric patient. It includes detail information about mucus, advantages, disadvantages of drug delivery system, mechanism , factors affecting on mucoadhesive drug delivery, mucoadhesive dosage form, mucoadhesive polymer and application of mucoadhesive drug delivery system.

Keywords

Mucoadhesion, Bio adhesion, polymer, Mucosa, Factors

Reference

  1. Khan Shahid, Verma Mayank, Aggarwal Geeta and Kumar S.L. Hari. Mucoadhesive drugdelivery system a: review. Volume-5 (2016) 392-405
  2. Ritu M Gilhotra, Mahd Ikram, Sunny Srivastava and Neeraj Gilhotra. A clinical Perspective on mucoadhesive buccal drug delivery system. (2013) 81-97.
  3. Madan Jyotsana, Banode Sagar, Dangi Mahesh. Mucosal drug delivery system volume -1(2010) 63-70.
  4. Priya Mahajan, Amanpreet Kaur, Geeta Aggarwal, S.L. Harikumar mucoadhesive drug delivery system a review volume-5 (2013) 11-20.
  5. Suryawanshi Rhushikesh ,Sudke Suresh. A review on mucoadhesive drug delivery system volume -7 (2020) 793- 808.
  6. Hitanshi Kulinsinh Parmar, Kartik Kirit Pandya, Lalit Jitendrabhai Pardasani, Vibhuti Sanjev Panchal and Hemal Thakorbhai Tandel. A systemic review on mucoadhesive drug delivery system volume- 6 (2017) 337-366
  7. Bindi M. Oedipally, Zulkar N.K. Mohammed, Ravinder Nath A. David Banji, mucoadhesive drug delivery system: on overview volume- 1(2010) 381-387
  8. Singh R, Sharma D. and Garg R. Review on mucoadhesive drug delivery system with special emphasis on buccal route: An important tool in designing of novel controlled drug delivery system for the effective delivery of pharmaceuticals volume -6 (2017) 1-12.
  9.  Flavia Chiva Carvalho, Marcos Luciano Bruschi, Raul Cesar Evangelista, Maria Palmira Daflon Gremiao. Mucoadhesive drug delivery systems. Volume-46 (2010) 1-17.
  10.  Ashish B.Budhrani , Ajay K.Shadija. mucoadhesive buccal drug delivery system A review. Volume-10 (2020) 274- 285.
  11. Sharaf Alawdi, Ajay B. Solanki. Mucoadhesive drug delivery system: A review of recent developments volume-2 (2021) 51-64
  12.  A.Deevan Paul , P. Samatha ,S.Manasa, R.Munemma, D. Supriya. Modelling the oral cavity with mucoadhesive drug delivery system -A potential alternative to conventional therapy volume-9 (2017) 299-307.
  13. Radha Bhati and Raja.K. Nagrajan. A detailed review on oral mucosal drug delivery system volume-3 (2012) 659-681.
  14. Flavia Chiva Carvalho, Marcos Luciano Bruschi, Raul Cesar Evangelista, Maria Palmira Daflon Gremiao. Mucoadhesive drug delivery systems. Volume-46 (2010) 1-17.
  15. Parthasarathi Subramanian mucoadhesive delivery system: A smart way to improve bioavailability of nutraceuticals (2021) 1-22.
  16. Graciela Lizeth, Perez-Gonzalez, Luis Jesus Villarreal – Gomez, Aracely Serrano – Medina, Erick Jose, Torres – Martinez, Jose Manuel Cornejo – Bravo. Mucoadhesive electrospun nonfibers for drug delivery systems: Applications of polymer and the parameters roles (2019) 5271-5285.
  17. Rahamatullah Shaikh, Thakur Raghu Raj Singh, Martin James Garland, A David Woolfson and Ryan F. Donnelly. Mucoadhesive drug delivery systems volume-3 (2011) 89-1.

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Rutuja S. Pawar
Corresponding author

Shri Ganapati institute of pharmaceutical science and research, Tembhurni

Photo
Sukumar M. Lande
Co-author

Shri Ganapati institute of pharmaceutical science and research, Tembhurni

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Rupali R. Bendgude
Co-author

Shri Ganapati institute of pharmaceutical science and research, Tembhurni

Rutuja S. Pawar*, Sukumar M. Lande, Rupali R. Bendgude, Review: A mucoadhesive drug delivery system, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 829-835. https://doi.org/10.5281/zenodo.10435594

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