Pharmacognostic Study and the Various Activities of Different Parts of Galinsoga parviflora (Cav.)

Galinsoga parviflora (Cav.), commonly known as gallant soldier, small-flowered galinsoga, or potato weed, is an annual herbaceous plant belonging to the Asteraceae family. Traditionally, this plant has been used for several therapeutic purposes, including the treatment of malaria, flu, colds, colorectal cancer, liver disorders, and inflammation (2). Its medicinal importance is mainly attributed to the presence of phytochemical constituents such as flavonoids, saponins, terpenoids, and tannins.

Hyperlipidemia is a major risk factor for cardiovascular diseases, and the global prevalence of dyslipidemia is steadily increasing. Conventional lipid-lowering drugs are often associated with adverse effects, which has created a demand for safer herbal formulations (1,13). Although specific studies on the cholesterol-lowering potential of G. parviflora are limited, the plant contains flavonoids and phenolic compounds that are known for their antioxidant and cardioprotective roles in other members of the Asteraceae family (3,6,11). Standardization and quality control of herbal formulations are necessary to ensure reproducibility and therapeutic reliability (14).

This review summarizes the pharmacognostic features, habitat, traditional uses, phytochemistry, extraction methods, and biological activities of G. parviflora strictly based on the data provided in the synopsis.

HABITAT

Galinsoga parviflora originates from North India, including regions such as Mandi (Himachal Pradesh), and is now widely distributed across temperate regions of the world (2). The plant commonly grows in disturbed soils, agricultural fields, gardens, and waste areas. Due to its strong ecological adaptability, the species is currently present in more than 130 countries, demonstrating significant ecological flexibility (15,16).

TRADITIONAL USES

Traditional medicinal uses of G. parviflora include (2,23):

• Treatment of inflammation
• Wound healing
• Relief from colds and flu
• Management of digestive discomfort
• Toothache and skin-related conditions
• Use as a general tonic

These applications reflect the presence of bioactive compounds identified in phytochemical studies.

BOTANICAL OVERVIEW

Scientific Name: Galinsoga parviflora (Cav.)
Family: Asteraceae
Common Names: Gallant soldier, potato weed, small-flowered galinsoga

Morphological Characteristics (18):

• Stem: Erect, green, striated, branched, and either smooth or hairy
• Leaves: Opposite, ovate to lanceolate in shape, with serrated margins, measuring 1–6 cm in length
• Inflorescence: Small flower heads with a diameter of 3–5 mm
• Flowers: White ray florets surrounding yellow disc florets
• Seeds: Small, black, wedge-shaped, measuring about 1–1.5 mm
• Root System: Shallow and fibrous

The Asteraceae family contains many medicinal species rich in flavonoids and terpenoids, which contribute to antioxidant and cardioprotective activities (17).

EXTRACTION METHODS

The studies describes the preparation of extracts as follows:

• Leaf Extraction: Ethanolic and hydroalcoholic leaf extracts have demonstrated antioxidant, antidiabetic, anti-inflammatory, and anti-obesity activities (15–18).
• Aerial Part Extraction: Hydroalcoholic Soxhlet extraction using 70% ethanol yields flavonoids, phenolics, and other metabolites relevant for antioxidant and cholesterol-lowering studies (23).

These extracts are used for standardized evaluation, including HMG-CoA reductase inhibition and DPPH assays.

ACTIVITIES OF DIFFERENT PARTS OF GALINSOGA PARVIFLORA

Leaves

According to the studies, leaf extracts exhibit:

• Antioxidant activity (15,16)
• Antidiabetic activity (4,16)
• Anti-inflammatory activity (17)
• Anti-obesity activity (18)

Silver nanoparticle preparations from leaf extracts further enhance antidiabetic effects by inhibiting glucose-metabolizing enzymes (4).

Aerial Parts

Aerial parts are used for hydroalcoholic extraction and show:

• High phenolic and flavonoid content
• Antioxidant activity based on DPPH assay
• Potential for cholesterol-lowering through HMG-CoA reductase inhibition

These properties support their inclusion in standardized herbal formulations.

PHYSICOCHEMICAL AND PHYTOCHEMICAL CHARACTERISTICS

The various studies identifies several categories of phytochemicals:

Flavonoids

Quercetin derivatives, rutin, and kaempferol have been reported across phytochemical studies (2,6,7). Flavonoids influence cholesterol metabolism in vitro but show limited plasma cholesterol reduction in vivo due to poor bioavailability (11).

Phenolic Compounds

Variations in total phenolic content are associated with antioxidant activity in medicinal plants, including G. parviflora (5,18).

Other Phytochemicals (2,6)

• Saponins
• Terpenoids
• Tannins
• Polysaccharides
• Essential oils
• Trace alkaloids

Analytical Techniques

The researches refers to the use of HPLC, LC-MS, GC-MS, NMR, metabolomic approaches, and phytochemical screening methods for profiling plant constituents (5,7,22). These techniques support standardization in herbal tablet formulations.

CONCLUSION

Based strictly on the provided synopsis, Galinsoga parviflora (Cav.) is a medicinal herb rich in flavonoids, phenolics, and other secondary metabolites responsible for antioxidant, anti-inflammatory, antidiabetic, and anti-obesity activities. The plant’s traditional uses correspond with its documented phytochemical profile. Preliminary studies on its cholesterol-lowering potential through HMG-CoA reductase inhibition indicate promising therapeutic value. The development and standardization of herbal formulations containing G. parviflora are justified by its pharmacological properties and traditional significance.

REFERENCES

1. Ezeh KJ, Ezeudemba O. Hyperlipidemia: a review of the novel methods for the management of lipids. Cureus. 2021 Jul 15;13(7):e16412. doi:10.7759/cureus.16412.
2. Ripanda A, Luanda A, Sule KS, Mtabazi GS, Makangara JJ. Galinsoga parviflora (Cav.): a comprehensive review on ethnomedicinal, phytochemical and pharmacological studies. Heliyon. 2023;9(2):e13517. doi:10.1016/j.heliyon.2023.e13517.
3. Shehzad A, Rehman G, Ul-Islam M, Khattak WA, Lee YS. Flavonoids as potential anti-inflammatory molecules: a review. Molecules. 2022;27(9):2901. doi:10.3390/molecules27092901.
4. Bhat WH, Ahmed SS. Evaluation of in vitro antidiabetic activity using silver nanoparticles of Galinsoga parviflora leaf extract. Int J Basic Clin Pharmacol. 2024;13(5):629–35. doi:10.18203/2319-2003.ijbcp20242420.
5. Tiranakwit T, Kulsing C, Prommaban A, Udomsin O, Chintong S, Kittiworawat S, et al. Phytochemical screening on phenolic, flavonoid contents, and antioxidant activities of six indigenous plants used in traditional Thai medicine. Int J Mol Sci. 2023;24(17):13425. doi:10.3390/ijms241713425.
6. Michel J, Abd Rani NZ, Husain K. A review on the potential use of medicinal plants from Asteraceae and Lamiaceae plant family in cardiovascular diseases. Front Pharmacol. 2020;11:852. doi:10.3389/fphar.2020.00852.
7. Salem MA, Perez de Souza L, Serag A, Fernie AR, Farag MA, Ezzat SM, et al. Metabolomics in the context of plant natural products research: from sample preparation to metabolite analysis. Metabolites. 2020;10(1):37. doi:10.3390/metabo10010037.
8. Riyad P, Purohit A, Sen K, Panwar A. HMG-CoA reductase inhibition mediated hypocholesterolemic potential of myricetin and quercetin: in-silico and in-vivo studies. Food Sci Technol Int. 2023;29(7):657–70. doi:10.1177/10820132221145642.
9. Flores-Hernández EJ, Flores-Hernández FY, Salazar-Montes AM, Nario-Chaidez HF, Hernández-Ortega LD. Quercetin, a flavonoid with great pharmacological capacity. Molecules. 2024;29(5):1000. doi:10.3390/molecules29051000.
10. Zhang W, Zheng Y, Yan F, Dong M, Ren Y. Research progress of quercetin in cardiovascular disease. Front Cardiovasc Med. 2023;10:1203713. doi:10.3389/fcvm.2023.1203713.
11. Liang N, Li YM, He Z, Hao W, Zhao Y, Liu J, et al. Rutin and quercetin decrease cholesterol in HepG2 cells but not plasma cholesterol in hamsters by oral administration. Molecules. 2021;26(12):3766. doi:10.3390/molecules26123766.
12. World Health Organization. Quality control methods for herbal materials [Internet]. Geneva: World Health Organization; 2011 [cited 2024 Jan 15]. Available from: https://www.who.int/publications/i/item/9789241500739.
13. Hasani-Ranjbar S, Vahidi H, Mirhosseini N, Ziaee A, Heshmat R, Abdollahi M. Targeting dyslipidemia by herbal medicines: a systematic review of meta-analyses. J Ethnopharmacol. 2021;276:114186. doi:10.1016/j.jep.2021.114186.
14. Maqsood M, Ahmed D, Atique I, Malik W. Advancing herbal medicine: enhancing product quality and safety through robust quality control practices. Front Pharmacol. 2023;14:1265178. doi:10.3389/fphar.2023.1265178.
15. Sultanova RA, Tembotov RK, Golovko EA. Ecological niche modeling of Galinsoga Ruiz et Pav. species in the native and Caucasian part of the invasive ranges. Russ J Biol Invasions. 2022;13(2):229–44. doi:10.1134/S2075111722020096.
16. Wang J, Zeng Z, Chen Y, La Q. Predicting the potential risk area of the invasive plant Galinsoga parviflora in Tibet using the MaxEnt model. Sustainability. 2024;16(11):4689. doi:10.3390/su16114689.
17. Caverzan A, Piasecki C, Chavarria G, Stewart CN Jr, Vargas L. Plants of the Asteraceae family as agents in the protection of human health: a review. Int J Mol Sci. 2021;22(6):3009. doi:10.3390/ijms22063009.
18. Ullah A, Munir S, Badshah SL, Khan N, Ghani L, Poulson BG, et al. Therapeutic potential of phenolic compounds in medicinal plants - natural health products for human health. Molecules. 2023;28(4):1845. doi:10.3390/molecules28041845.
19. Nicolescu A, Bunea CI, Mocan A. Total flavonoid content revised: an overview of past, present, and future determinations in phytochemical analysis. Anal Biochem. 2025;700:115794. doi:10.1016/j.ab.2025.115794.
20. Chen L, Hu C, Hood M, Zhang X, Zhang L, Kan J, et al. Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects. Chin Med. 2022;17:113. doi:10.1186/s13020-022-00651-w.
21. Wong A, Ke YH, Lai CK, Hsia TC, Chen JC, Cheng YC. The effects and safety of Chinese herbal medicine on blood lipid profiles in placebo-controlled weight-loss trials: a systematic review and meta-analysis. Evid Based Complement Alternat Med. 2022;2022:1368576. doi:10.1155/2022/1368576.
22. Li Q, Wang Y, Li M, Li Y, Chen L, Li H. Advances in fingerprint analysis for standardization and quality control of herbal medicines. Front Pharmacol. 2022;13:853023. doi:10.3389/fphar.2022.853023.
23. Studzi?ska-Sroka E, Dudek-Makuch M, Chanaj-Kaczmarek J, Czepulis N, Korybalska K, Rutkowski R, et al. Anti-inflammatory activity and phytochemical profile of Galinsoga parviflora Cav. Molecules. 2018;23(9):2133. doi:10.3390/molecules23092133.
24. Mahdavi A, Bagherniya M, Fakheran O, Reiner Ž, Jamialahmadi T, Sahebkar A. Medicinal plants and bioactive natural compounds as inhibitors of HMG-CoA reductase: a literature review. Biofactors. 2020;46(6):906–26. doi:10.1002/biof.1684.
25. Savic IM, Nikolic VD, Savic-Gajic IM, Kundakovic TM, Stanojkovic TP. Multivariate statistical optimization of tablet formulations incorporating high doses of a dry herbal extract. Molecules. 2019;24(4):689. doi:10.3390/molecules24040689.