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Himalayan Pharmacy Institute, Majhitar, East Sikkim-737136, Sikkim, India
Helminthiasis illness is a common health risk for the population of all the ages throughout the world. The different major diseases caused by the infection are responsible for incremental mortality and morbidity statistics. From the older days in many civilizations the helminthes infection can be treated by different herbal medicines of dietary sources. This present study aimed to validate the traditional claim of anthelmintic activity of the herb Chenopodium ambrosioides. The petroleum ether extract of Chenopodium ambrosioides leaf (CALE) was used for the study and the presence of different phyto-constituents were observed. Indian earthworms Pheretima posthuman were incorporated in the different concentrations of Chenopodium ambrocioides leaf extract (5, 10 and 20 mg/ml). The paralysis time and the death time were noted and compared with the standard drug Albendazole. The phytochemical screening of the extracts gives positive indication of alkaloids, proteins, aminoacids, anhtraquinones, flavonoids, tannins, saponins, reducing sugar, steroids, triterpenoids and cardiac glycosides. The Chenopodium ambrocioides leaf extract in different concentrations showed significant anthelmintic activity. The potential of the effect was in the dose dependent manner. This study can be concluded as potential Anthelmintic activity of Chenopodium ambrosioides leaf Extract. Further studies are required to establish the fact clinically.
Rahul Pradhan, Praghya Sharma, Nikki Kumari Gupta, Samir Chouhan, Nowsad SK, Manodeep Chakraborty*, Phytochemical Analysis and Potential Anthelmintic activity of Chenopodium ambrosioides Leaf Extract, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 443-450. https://doi.org/10.5281/zenodo.10203953
10.5281/zenodo.10203953