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1Student Kishori college of pharmacy Beed
2Assistant professor Kishori college of pharmacy Beed
3Principal Kishori college of pharmacy Beed
Collaborative research projects between chemists, biologists, and medical scientists have inevitably produced many useful drugs, biosensors, and medical instrumentation. Organic chemistry lies at the heart of drug discovery and development. The current range of organic synthetic methodologies allows for the construction of unlimited libraries of small organic molecules for drug screening. In translational research projects, we have focused on the discovery of lead compounds for three major diseases: Alzheimer disease, breast cancer, and viral infections. In the Alzheimer disease project, we have taken a rational-design, approach and synthesized a new class of tricyclic pyrone compounds that preserve memory and motor functions in amyloid precursor protein /presenilin-1 mice. TP's could protect neuronal death through several possible mechanisms, including their ability to inhibit the formation of both intraneuronal and extracellular amyloid B aggregates, to increase cholesterol efflux, to restore axonal trafficking, and to enhance long-term potentiation and restored LTP following treatment with amyloid B Oligomers.
Pravin D. Chand, Prachi P. Udapurkar, A. S. Sanap, Structure Biosynthesis And Examination Of Bioactive Small Molecule, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 139-144. https://doi.org/10.5281/zenodo.10625232
10.5281/zenodo.10625232