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  • Synergistic Integration of Buoyancy and Mucoadhesion: A Comprehensive Review on Formulation Strategies and Clinical Prospects of Floating-Mucoadhesive Tablets for Enhancing the Bioavailability of Gastric-Absorbed Drugs

  • Laddhad College of Pharmacy, Yelgaon, Buldhana, Tq. Buldhana, Dist. Buldhana (M.S.) – 443001

Abstract

Floating-mucoadhesive drug delivery system integrates gastric retention and mucoadhesion to extend the gastric residence time, and therefore, drug release is maintained at the absorption site. The present review addresses the strategies of formulations, mechanism of buoyancy and mucoadhesion, the variables that are influenced, approaches to characterization and the future of floating-mucoadhesive tablets (FMTs) to deliver gastric-absorbed drugs. Gastric retention improves solubility and bioavailability of drugs with low absorption half-lives and pH-sensitive drugs. FMTs make use of low density excipients and gas generating agents to realize buoyancy, and mucoadhesive polymers enhance mucosa tightness adhesion to gastric mucosa. We are summing up design parameters like the type of polymer, tablet geometry and swelling behavior. Issues like fluctuation of gastric emptying, food effect and patient to patient differences are emphasized. There is preclinical and clinical evidence of better pharmacokinetic characteristics of model drugs such as antibiotics, antidiabetics and agents with narrow absorption windows such as cardiovascular agents. Future trends and regulatory issues such as the incorporation of nanotechnology and in-situ gelling systems are given. The review offers an elaborate guide to pharmaceutical scientists and formulators who seek to improve the oral bioavailability by adopting gastroretentive approaches.

Keywords

Floating–Mucoadhesive Tablets; Gastroretentive Drug Delivery System; Buoyancy and Mucoadhesion; Gastric Retention; Bioavailability Enhancement

Introduction

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  1. Singh BN, Kim KH, Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention, Journal of Controlled Release, 2000; 63(3):235–259. DOI: https://doi.org/10.1016/S0168-3659(99)00204-7
  2. Gadge AR, Lamkhade GJ, Vishe SU, Varpe MM, et al., Floating drug delivery systems: A review, World Journal of Biology Pharmacy and Health Sciences, 2024;18(2):065-073.    DOI:https://doi.org/10.30574/wjbphs.2024.18.2.0249
  3. Gupta RK, Panda P, Kumar D, An Overview on The Analysis of The Floating Drug Delivery System, World Journal of Pharmaceutical Research, 2024; 13(11):708-724. DOI: https://doi.org/10.20959/wjpr202411-32654
  4. Gupta P, Gnanarajan PK, Kothiyal P, Floating drug delivery system: a review, International Journal of Pharma Research & Review, 2015; 4(8):37-44.
  5. Singh J, Deep P, A review article on mucoadhesive buccal drug delivery system, International journal of pharmaceutical sciences and research, 2013; 4(3):916-927. DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).916-27
  6. Banker GS, Rhodes CT, Modern Pharmaceutics, Marcel Dekker, New York 1996; 3(1):125-128. DOI: https://doi.org/10.1201/9780824744694
  7. Hoffman A, Pharmacodynamic aspects of sustained release preparations, Advanced drug delivery reviews, 1998; 33(3):185-199. DOI: https://doi.org/10.1016/s0169-409x(98)00027-1
  8. Kothule S, Aher S, BachhavR. Gastro-retentive Drug Delivery System: A Review. International Journal in Pharmaceutical Science. 2023; 2(1):75-85.
  9. Pandey SK, Pudasaini J, Parajuli N, Singh RE,  et al., Formulation and evaluation of floating tablet of Nimesulide by direct compression method, Magna Scientia Advanced Research and Reviews, 2024; 10(1): 153-161. DOI: https://doi.org/10.30574/msarr.2024.10.1.0008
  10. Patole R, Chaware B, Mohite V, Redasani V, A Review for Gastro-Retentive Drug Delivery System, Asian Journal of Pharmaceutical Research and Development, 2023; 11(4):79-94. https://doi.org/10.22270/ajprd.v11i4.1291
  11. Moës AJ, Gastric Retention Systems for Oral Drug Delivery, Drug Delivery Oral, Pharmtech, 2003; 3(7):157-159.
  12. Well LJ, Gardner RC, Cargill RC, Drug delivery device which can be retained in the stomach for a controlled period of time, US Patent 1998; 30: 4, 767, 627.
  13. Kotreka U, Adeyeye MC, Gastroretentive floating drug-delivery systems: a critical review, Critical Reviews™ in Therapeutic Drug Carrier Systems, 2011; 28(1):47-99. DOI: https://doi.org/10.1615/critrevtherdrugcarriersyst.v28.i1.20
  14. Awasthi R, Kulkarni GT, Development and characterization of floating drug delivery system: A review, Asian Journal of Pharmaceutical and Clinical Research, 2013; 6(5):1–9.
  15. Singh BN, Kim KH, Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention, Journal of Controlled release, 2000; 63(3):235-259. DOI: https://doi.org/10.1016/S0168-3659(99)00204-7
  16. Prajapati ST, Patel L, Patel C, Floating matrix tablets of domperidone: formulation and optimization using simplex lattice design, Iranian journal of pharmaceutical research, 2011; 10(3):447-455. DOI:2011;61(4):567-585. 10.22037/IJPR.2010.892
  17. Kumar R, Patil S, Design and in vitro evaluation of sustained release floating tablets of metformin HCl, Asian Journal of Pharmaceutics, 2009; 3(3):240-245.
  18. Singh BN, Kim KH, Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention, Journal of Controlled release, 2000; 63(3):235-259. DOI: https://doi.org/10.1016/S0168-3659(99)00204-7
  19. Repka MA, Majumdar S, Kumar Battu S, Srirangam R, et al., Applications of hot-melt extrusion for drug delivery, Expert opinion on drug delivery,   2007;4(2):135-151.
  20. Bhuyar SR, Auti MM, Bhise SA, Innovations and advancements in floating tablet drug delivery systems: a comprehensive review, Pharm Pharmacol Int J, 2024;12(5):195-200. DOI: https://doi.org/10.15406/ppij.2024.12.00452
  21. Vasave VS, A Review on: Floating Drug Delivery System, World Journal of Pharmaceutical Research, 2023; 12(2):641-669. DOI: https://doi.org/10.20959/wjpr20232-26983
  22. Thakur S, Ramya K, Shah DK, Raj K, Floating Drug Delivery System, Journal of Drug Delivery and Therapeutics, 2021; 11(3-S):125-130. DOI: http://dx.doi.org/10.22270/jddt.v11i3-S.4828
  23. Singh LP, Rajesh KS, Umalkar DG, Chauhan VK, et al., Floating effervescent tablet: A review, Journal of pharmaceutical and biomedical sciences, 2011;5(11):1-6.
  24. Pawar VK, Kansal S, Garg G, Awasthi R, et al., Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems, Drug delivery, 2011; 18(2):97-110. DOI: https://doi.org/10.3109/10717544.2010.520354
  25. Padhan A, Nanda BK, Behera BC, Floating oral in-situ gel, a comprehensive approach of gastro-retentive drug delivery system: a review, International journal of pharmaceutical sciences and research, 2019;10(9):4026-4039. DOI: https://doi.org/10.13040/IJPSR.0975-8232.10(9).4026-39
  26. Chowdary KP, Teeda V, Floating drug delivery systems: a review of recent research, International Research Journal of Pharmaceutical and Applied Sciences, 2014; 4(4):14-24.
  27. Grover I, Marwah M, Devgan M, Floating Drug Delivery Systems: A Novel Approach, Research Journal of Pharmacy and Technology, 2015; 8(4):490-495. DOI: https://doi.org/10.5958/0974-360X.2015.00082.7
  28. Mathur P, Verma N, Floating drug delivery system, An innovative acceptable approach in gastro retentive drug delivery, Scholars Research Library, 2010; 2(2):257-270.
  29. Hardenia SS, Jain A, Patel R, Kaushal A, Floating Drug Delivery Systems: A Review, Asian Journal of Pharmacy and Life Science, 2011; 1(3):284-293.
  30. Chandel A, Chauhan K, Parashar B, Kumar H, et al., Floating drug delivery systems: A better approach, International Current Pharmaceutical Journal, 2012; 1(5):110-118. DOI: http://www.icpjonline.com/documents/Vol1Issue5/04.pdf
  31. Shah SH, Patel JK, Patel NV, Stomach specific floating drug delivery system: A review, International Journal of Pharmaceutical Technology and Research, 2009; 1(3):623-633.
  32. Rajora A, Nagpal K, A Critical Review on Floating Tablets as a Tool for Achieving Better Gastric Retention, Critical Reviews™ in Therapeutic Drug Carrier Systems, 2022; 39(1):65–103.
  33. Shaik K, Hindustan AA, Haranath C, Peddagundam B, Lakunde J, Tarun K, Gas Generating Floating Tablets: A Quick Literature Review for the Scholars, Asian Journal of Research in Chemistry, 2022; 15(2):171-175. doi: https://doi.org/10.52711/0974-4150.2022.00029 .
  34. Lieberman HA, Lachman L. Pharmaceutical dosage forms: Tablets. Research Articles: 2009.
  35. Borude SS, Mandhare TA, Kashid PS, Otari K, An overview of floating tablet, Asian Journal of Pharmaceutical Research and Development, 2024; 12(4):133–137. https://doi.org/10.22270/ajprd.v12i4.1453
  36. Timmermans J, Moës AJ, Factors controlling the buoyancy and gastric retention capabilities of floating matrix capsules: new data for reconsidering the controversy, Journal of pharmaceutical sciences, 1994;83(1):18-24.DOI: https://doi.org/10.1002/jps.2600830106  
  37. Gohel MC, Mehta PR, Dave RK, Bariya NH, A more relevant dissolution method for evaluation of a floating drug delivery system, Dissolution technologies, 2004;11: 22-26. DOI: https://doi.org/10.14227/DT110404P22
  38. Hou W, Miyazaki S, Takada M, Komai T, Sustained release of indomethacin from chitosan granules, Chemical and pharmaceutical bulletin, 1985; 33(9):3986-3992. DOI: https://doi.org/10.1248/cpb.33.3986
  39. Hajare AA, Patil VA, Formulation and characterization of metformin hydrochloride floating tablets, Asian Journal of Pharmaceutical Research, 2012;2(3):111-117. 
  40. Patil P, Rao BS, Kulkarni SV, Surpur C, et al., Formulation and in vitro evaluation of floating matrix tablets of ofloxacin, Asian Journal of Research in Pharmaceutical Science, 2011; 1(1):17-22.
  41. Salve PS, Effect of excipients and processing parameters on floating characteristics of hydrodynamically balanced system for diltiazem hydrochloride, Asian Journal of Research in Pharmaceutical Science, 2011;1(4):97-99.
  42. Patel N, Patel J, Modasiya M, Formulation and In Vitro Evaluation of Glipizide as Floating Drug Delivery System. Asian Journal of Pharmacy and Technology, 2012;2(2):67-73.
  43. Patel MP, Patel MM, Patel KN, Patel DR, et al., Designing and evaluation of floating microspheres of Verapamil Hydrochloride: Effect of Methocel, Research journal of pharmaceutical dosage forms and technology, 2009;1(1):22-28.
  44. Dhamecha DI, Rathi AA, Saifee M, Lahoti SR, et al., Development and In Vitro Evaluation of Oral Floating Matrix Tablet Formulation of Ranitidine Hydrochloride, Research Journal of Pharmaceutical Dosage Forms and Technology, 2009;1(1):41-44.
  45. Chaudhari KD, Nimbalwar MG, Singhal NS, Panchale WA, Manwar JV, Bakal RL, Comprehensive review on characterizations and application of gastro-retentive floating drug delivery system, GSC Advanced Research and Reviews, 2021; 07(01):035–044. https://doi.org/10.30574/gscarr.2021.7.1.0070
  46. Birajdar AA, Deshmukh MT, Shete RV, A review on gastro-retentive floating microspheres, Journal of Drug Delivery and Therapeutics, 2021; 11(1-s):131-138. DOI: https://doi.org/10.22270/JDDT.V11I1-S.4518
  47. Mora-Castaño G, Domínguez-Robles J, Himawan A, Millán-Jiménez M, Caraballo I, Current trends in 3D printed gastroretentive floating drug delivery systems: A comprehensive review, International Journal of Pharmaceutics, 2024; 663:124543. https://doi.org/10.1016/j.ijpharm.2024.124543
  48. Kumar S, Keerthy HS, Yadav RP, Role of Floating Tablet in Oral Drug Delivery System, Asian Journal of Pharmaceutical Research and Development, 2021; 9(3):104-111. http://dx.doi.org/10.22270/ajprd.v9i3.951
  49. Kumar S, Chohan JS, Kaur H, Kasnia R, Demiwal S,Nehra   B, An   Updated    Overview   of   Gastro-retentive    Floating     Drug    Delivery    Systems: Formulation  Strategies   and  Application,Journal of    Drug     Delivery    and    Therapeutics.    2024; 14(8):175-182 http://dx.doi.org/10.22270/jddt.v14i8.6726
  50. Mayavanshi AV, Gajjar SS, Floating drug delivery systems to increase gastric retention of drugs: A Review, Research Journal of Pharmacy and Technology, 2008;1(4):345-348.

Reference

  1. Singh BN, Kim KH, Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention, Journal of Controlled Release, 2000; 63(3):235–259. DOI: https://doi.org/10.1016/S0168-3659(99)00204-7
  2. Gadge AR, Lamkhade GJ, Vishe SU, Varpe MM, et al., Floating drug delivery systems: A review, World Journal of Biology Pharmacy and Health Sciences, 2024;18(2):065-073.    DOI:https://doi.org/10.30574/wjbphs.2024.18.2.0249
  3. Gupta RK, Panda P, Kumar D, An Overview on The Analysis of The Floating Drug Delivery System, World Journal of Pharmaceutical Research, 2024; 13(11):708-724. DOI: https://doi.org/10.20959/wjpr202411-32654
  4. Gupta P, Gnanarajan PK, Kothiyal P, Floating drug delivery system: a review, International Journal of Pharma Research & Review, 2015; 4(8):37-44.
  5. Singh J, Deep P, A review article on mucoadhesive buccal drug delivery system, International journal of pharmaceutical sciences and research, 2013; 4(3):916-927. DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(3).916-27
  6. Banker GS, Rhodes CT, Modern Pharmaceutics, Marcel Dekker, New York 1996; 3(1):125-128. DOI: https://doi.org/10.1201/9780824744694
  7. Hoffman A, Pharmacodynamic aspects of sustained release preparations, Advanced drug delivery reviews, 1998; 33(3):185-199. DOI: https://doi.org/10.1016/s0169-409x(98)00027-1
  8. Kothule S, Aher S, BachhavR. Gastro-retentive Drug Delivery System: A Review. International Journal in Pharmaceutical Science. 2023; 2(1):75-85.
  9. Pandey SK, Pudasaini J, Parajuli N, Singh RE,  et al., Formulation and evaluation of floating tablet of Nimesulide by direct compression method, Magna Scientia Advanced Research and Reviews, 2024; 10(1): 153-161. DOI: https://doi.org/10.30574/msarr.2024.10.1.0008
  10. Patole R, Chaware B, Mohite V, Redasani V, A Review for Gastro-Retentive Drug Delivery System, Asian Journal of Pharmaceutical Research and Development, 2023; 11(4):79-94. https://doi.org/10.22270/ajprd.v11i4.1291
  11. Moës AJ, Gastric Retention Systems for Oral Drug Delivery, Drug Delivery Oral, Pharmtech, 2003; 3(7):157-159.
  12. Well LJ, Gardner RC, Cargill RC, Drug delivery device which can be retained in the stomach for a controlled period of time, US Patent 1998; 30: 4, 767, 627.
  13. Kotreka U, Adeyeye MC, Gastroretentive floating drug-delivery systems: a critical review, Critical Reviews™ in Therapeutic Drug Carrier Systems, 2011; 28(1):47-99. DOI: https://doi.org/10.1615/critrevtherdrugcarriersyst.v28.i1.20
  14. Awasthi R, Kulkarni GT, Development and characterization of floating drug delivery system: A review, Asian Journal of Pharmaceutical and Clinical Research, 2013; 6(5):1–9.
  15. Singh BN, Kim KH, Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention, Journal of Controlled release, 2000; 63(3):235-259. DOI: https://doi.org/10.1016/S0168-3659(99)00204-7
  16. Prajapati ST, Patel L, Patel C, Floating matrix tablets of domperidone: formulation and optimization using simplex lattice design, Iranian journal of pharmaceutical research, 2011; 10(3):447-455. DOI:2011;61(4):567-585. 10.22037/IJPR.2010.892
  17. Kumar R, Patil S, Design and in vitro evaluation of sustained release floating tablets of metformin HCl, Asian Journal of Pharmaceutics, 2009; 3(3):240-245.
  18. Singh BN, Kim KH, Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention, Journal of Controlled release, 2000; 63(3):235-259. DOI: https://doi.org/10.1016/S0168-3659(99)00204-7
  19. Repka MA, Majumdar S, Kumar Battu S, Srirangam R, et al., Applications of hot-melt extrusion for drug delivery, Expert opinion on drug delivery,   2007;4(2):135-151.
  20. Bhuyar SR, Auti MM, Bhise SA, Innovations and advancements in floating tablet drug delivery systems: a comprehensive review, Pharm Pharmacol Int J, 2024;12(5):195-200. DOI: https://doi.org/10.15406/ppij.2024.12.00452
  21. Vasave VS, A Review on: Floating Drug Delivery System, World Journal of Pharmaceutical Research, 2023; 12(2):641-669. DOI: https://doi.org/10.20959/wjpr20232-26983
  22. Thakur S, Ramya K, Shah DK, Raj K, Floating Drug Delivery System, Journal of Drug Delivery and Therapeutics, 2021; 11(3-S):125-130. DOI: http://dx.doi.org/10.22270/jddt.v11i3-S.4828
  23. Singh LP, Rajesh KS, Umalkar DG, Chauhan VK, et al., Floating effervescent tablet: A review, Journal of pharmaceutical and biomedical sciences, 2011;5(11):1-6.
  24. Pawar VK, Kansal S, Garg G, Awasthi R, et al., Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems, Drug delivery, 2011; 18(2):97-110. DOI: https://doi.org/10.3109/10717544.2010.520354
  25. Padhan A, Nanda BK, Behera BC, Floating oral in-situ gel, a comprehensive approach of gastro-retentive drug delivery system: a review, International journal of pharmaceutical sciences and research, 2019;10(9):4026-4039. DOI: https://doi.org/10.13040/IJPSR.0975-8232.10(9).4026-39
  26. Chowdary KP, Teeda V, Floating drug delivery systems: a review of recent research, International Research Journal of Pharmaceutical and Applied Sciences, 2014; 4(4):14-24.
  27. Grover I, Marwah M, Devgan M, Floating Drug Delivery Systems: A Novel Approach, Research Journal of Pharmacy and Technology, 2015; 8(4):490-495. DOI: https://doi.org/10.5958/0974-360X.2015.00082.7
  28. Mathur P, Verma N, Floating drug delivery system, An innovative acceptable approach in gastro retentive drug delivery, Scholars Research Library, 2010; 2(2):257-270.
  29. Hardenia SS, Jain A, Patel R, Kaushal A, Floating Drug Delivery Systems: A Review, Asian Journal of Pharmacy and Life Science, 2011; 1(3):284-293.
  30. Chandel A, Chauhan K, Parashar B, Kumar H, et al., Floating drug delivery systems: A better approach, International Current Pharmaceutical Journal, 2012; 1(5):110-118. DOI: http://www.icpjonline.com/documents/Vol1Issue5/04.pdf
  31. Shah SH, Patel JK, Patel NV, Stomach specific floating drug delivery system: A review, International Journal of Pharmaceutical Technology and Research, 2009; 1(3):623-633.
  32. Rajora A, Nagpal K, A Critical Review on Floating Tablets as a Tool for Achieving Better Gastric Retention, Critical Reviews™ in Therapeutic Drug Carrier Systems, 2022; 39(1):65–103.
  33. Shaik K, Hindustan AA, Haranath C, Peddagundam B, Lakunde J, Tarun K, Gas Generating Floating Tablets: A Quick Literature Review for the Scholars, Asian Journal of Research in Chemistry, 2022; 15(2):171-175. doi: https://doi.org/10.52711/0974-4150.2022.00029 .
  34. Lieberman HA, Lachman L. Pharmaceutical dosage forms: Tablets. Research Articles: 2009.
  35. Borude SS, Mandhare TA, Kashid PS, Otari K, An overview of floating tablet, Asian Journal of Pharmaceutical Research and Development, 2024; 12(4):133–137. https://doi.org/10.22270/ajprd.v12i4.1453
  36. Timmermans J, Moës AJ, Factors controlling the buoyancy and gastric retention capabilities of floating matrix capsules: new data for reconsidering the controversy, Journal of pharmaceutical sciences, 1994;83(1):18-24.DOI: https://doi.org/10.1002/jps.2600830106  
  37. Gohel MC, Mehta PR, Dave RK, Bariya NH, A more relevant dissolution method for evaluation of a floating drug delivery system, Dissolution technologies, 2004;11: 22-26. DOI: https://doi.org/10.14227/DT110404P22
  38. Hou W, Miyazaki S, Takada M, Komai T, Sustained release of indomethacin from chitosan granules, Chemical and pharmaceutical bulletin, 1985; 33(9):3986-3992. DOI: https://doi.org/10.1248/cpb.33.3986
  39. Hajare AA, Patil VA, Formulation and characterization of metformin hydrochloride floating tablets, Asian Journal of Pharmaceutical Research, 2012;2(3):111-117. 
  40. Patil P, Rao BS, Kulkarni SV, Surpur C, et al., Formulation and in vitro evaluation of floating matrix tablets of ofloxacin, Asian Journal of Research in Pharmaceutical Science, 2011; 1(1):17-22.
  41. Salve PS, Effect of excipients and processing parameters on floating characteristics of hydrodynamically balanced system for diltiazem hydrochloride, Asian Journal of Research in Pharmaceutical Science, 2011;1(4):97-99.
  42. Patel N, Patel J, Modasiya M, Formulation and In Vitro Evaluation of Glipizide as Floating Drug Delivery System. Asian Journal of Pharmacy and Technology, 2012;2(2):67-73.
  43. Patel MP, Patel MM, Patel KN, Patel DR, et al., Designing and evaluation of floating microspheres of Verapamil Hydrochloride: Effect of Methocel, Research journal of pharmaceutical dosage forms and technology, 2009;1(1):22-28.
  44. Dhamecha DI, Rathi AA, Saifee M, Lahoti SR, et al., Development and In Vitro Evaluation of Oral Floating Matrix Tablet Formulation of Ranitidine Hydrochloride, Research Journal of Pharmaceutical Dosage Forms and Technology, 2009;1(1):41-44.
  45. Chaudhari KD, Nimbalwar MG, Singhal NS, Panchale WA, Manwar JV, Bakal RL, Comprehensive review on characterizations and application of gastro-retentive floating drug delivery system, GSC Advanced Research and Reviews, 2021; 07(01):035–044. https://doi.org/10.30574/gscarr.2021.7.1.0070
  46. Birajdar AA, Deshmukh MT, Shete RV, A review on gastro-retentive floating microspheres, Journal of Drug Delivery and Therapeutics, 2021; 11(1-s):131-138. DOI: https://doi.org/10.22270/JDDT.V11I1-S.4518
  47. Mora-Castaño G, Domínguez-Robles J, Himawan A, Millán-Jiménez M, Caraballo I, Current trends in 3D printed gastroretentive floating drug delivery systems: A comprehensive review, International Journal of Pharmaceutics, 2024; 663:124543. https://doi.org/10.1016/j.ijpharm.2024.124543
  48. Kumar S, Keerthy HS, Yadav RP, Role of Floating Tablet in Oral Drug Delivery System, Asian Journal of Pharmaceutical Research and Development, 2021; 9(3):104-111. http://dx.doi.org/10.22270/ajprd.v9i3.951
  49. Kumar S, Chohan JS, Kaur H, Kasnia R, Demiwal S,Nehra   B, An   Updated    Overview   of   Gastro-retentive    Floating     Drug    Delivery    Systems: Formulation  Strategies   and  Application,Journal of    Drug     Delivery    and    Therapeutics.    2024; 14(8):175-182 http://dx.doi.org/10.22270/jddt.v14i8.6726
  50. Mayavanshi AV, Gajjar SS, Floating drug delivery systems to increase gastric retention of drugs: A Review, Research Journal of Pharmacy and Technology, 2008;1(4):345-348.

Photo
Bhushan Mante
Corresponding author

Laddhad College of Pharmacy, Yelgaon, Buldhana, Tq. Buldhana, Dist. Buldhana (M.S.) – 443001

Photo
Yogesh Vilhekar
Co-author

Laddhad College of Pharmacy, Yelgaon, Buldhana, Tq. Buldhana, Dist. Buldhana (M.S.) – 443001

Photo
Purvi Deshmukh
Co-author

: Laddhad College of Pharmacy, Yelgaon, Buldhana, Tq. Buldhana, Dist. Buldhana (M.S.) – 443001

Bhushan Mante,?Yogesh Vilhekar, ?Purvi Deshmukh, Synergistic Integration of Buoyancy and Mucoadhesion: A Comprehensive Review on Formulation Strategies and Clinical Prospects of Floating-Mucoadhesive Tablets for Enhancing the Bioavailability of Gastric-Absorbed Drugs., Int. J. of Pharm. Sci., 2026, Vol 4, Issue 3, 539-552. https://doi.org/10.5281/zenodo.18890473

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